Quasispecies and RNA virus evolution : principles and consequences /
Saved in:
| Imprint: | Georgetown, Tx. : Landes Bioscience, c2001. |
|---|---|
| Description: | 173 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Molecular biology intelligence unit ; 14 Molecular biology intelligence unit ; 14. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4450925 |
Table of Contents:
- 1.. Introduction
- Darwinian Evolution as the Principle of Biological Dynamics
- Genotype and Phenotype
- Viruses and Other Genetic Parasites
- The Central Dogma of Molecular Biology
- Molecular Programs
- RNA and the Origin of Life
- 2.. Multiplication Strategies of RNA Genetic Elements
- Biological Cloning of Viruses
- Four Basic Strategies of Virus Replication
- Strategies of RNA Virus Expression
- Prokaryotic RNA Viruses: Leviviridae
- Positive Strand RNA Viruses
- Negative Strand RNA Viruses
- Multipartite (Segmented Genome) RNA Viruses
- Subviral Agents
- Defective Viral Genomes
- Retroelements and Retroviruses
- Hepadnaviruses
- Disparate Life Cycles, Common Survival Strategies
- Early Evidence of RNA Virus Variability
- 3.. Molecular Recognition and Replication Enzymes
- Structure of Nucleic Acids and Restrictions to Variation
- Molecular Recognition of Nucleic Acids, and Selection for Nucleic Acid Structures: Compensatory Mutations
- Structure and Catalytic Properties of Proteins
- Quaternary Structures
- Replication Enzymes
- DNA-dependent DNA Polymerases
- RNA Replication
- Reverse Transcriptase
- Fidelity of RNA and DNA Polymerases and the Survival of Defective Genomes
- 4.. Quantitative Molecular Evolution
- Selection of the Fittest
- Mutant Spectra and Sequence Space
- Sequence Heterogeneity
- The Sequence Space
- The Quasispecies
- The Error Threshold
- 5.. Darwinian Evolution of RNA in Vitro
- The Kinetics of RNA Replication
- RNA Growth Rates
- Double Strand Formation
- Selection Among RNA Species
- Mutation in Replicating RNA
- Adaptation of RNA in Vitro
- Recombination Among RNA Molecules
- Can Biological Information Be Generated De Novo?
- Conditions for Replication
- 6.. Experimental Studies on Viral Quasispecies
- Molecular Mechanisms of Genetic Variation of RNA Viruses: Mutation, Recombination and Genome Segment Reassortment
- Rate of Accumulation (or Fixation) of Mutations, and Its Lack of Regularity
- Population Equilibrium: Stasis in the Face of High Mutation Rates
- Population Disequilibrium: The Trigger of Rapid RNA Genome Evolution
- Unequal Rate of Occurrence of Different Mutation Types
- Hypomutation and Hypermutation
- Genetic Heterogeneity of Natural Populations of RNA Viruses
- Quasispecies Dynamics in Vivo
- Rapid Generation of Variant Genomes in Cell Culture
- Connection between Genotype and Phenotype. Viral Quasispecies as Reservoirs of Phenotypic Variants: Episodic Selection
- Thresholds for Phenotypic Expression
- Host Range Mutants of RNA Viruses
- Quasispecies Dynamics and Antigenic Variation
- 7.. Population Dynamics and Virus Adaptability
- Repeated Population Bottlenecks Lead to Fitness Losses: Muller's Ratchet
- Molecular Basis of Fitness Decrease
- Fitness Increase of RNA Viruses: Quasispecies Optimization
- Multiple Molecular Pathways for Fitness Increase: a Wrightian View of RNA Virus Evolution
- Current Views on Fitness Evolution of RNA Viruses
- Complexity of Fitness Landscapes
- Evidence of Positive and Negative Selection Acting Continuously in Viral Populations
- Competition Between Neutral Variants: The Competitive Exclusion Principle and the Red Queen Hypothesis. Reproducible Nonlinear Population Dynamics
- Genetic Heterogeneity and Variability of DNA Viruses
- Extensions to Nonviral Systems: Mutation, Competition and Selection in Cell Populations
- Evolution of Bacteria. Resistance to Multiple Antibiotics as a Long-Term, Undesigned Experiment
- Evolutionary Potential of Unicellular Pathogens and Difficulties for the Control of Parasitic disease
- 8.. Connections, Implications and Prospects
- Relationships of Quasispecies with Population Genetics and Current Concepts of Complexity
- RNA Viruses and Evolutionary Biotechnology
- Quasispecies and Viral Disease Control Strategies
- New Antiviral Strategies Based on Violation of the Error Threshold
- The Emergence and Reemergence of Viral Diseases
- Overview
- Index
