Pharmacology /

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Bibliographic Details
Edition:4th ed. (USA ed.)
Imprint:New York : Churchill Livingstone, c2001.
Description:x, 839 p. : ill. ; 25 cm.
Language:English
Subject:
Format: Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/4515899
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Other authors / contributors:Rang, H.P.
ISBN:0443065748
Notes:Includes bibliographical references and index.
Table of Contents:
  • Section 1. General Principles
  • 1.. What is pharmacology?
  • Pharmacology in the 20th century
  • 2.. How drugs act: general principles
  • The binding of drug molecules to cells
  • Desensitisation and tachyphylaxis
  • 3.. How drugs act: molecular aspects
  • Targets for drug action
  • Receptor proteins
  • Ion channels as drug targets
  • Control of receptor expression
  • Receptors and disease
  • 4.. Cellular mechanisms: excitation, contraction and secretion
  • Regulation of intracellular calcium levels
  • Excitation
  • Muscle contraction
  • Release of chemical mediators
  • Epithelial ion transport
  • 5.. Cellular mechanisms: cell proliferation and apoptosis
  • Cell proliferation
  • Angiogenesis
  • Apoptosis and cell removal
  • Pathophysiological implications
  • Therapeutic implications
  • 6.. Method and measurement in pharmacology
  • Bioassay
  • Animal models of disease
  • Clinical trials
  • Balancing benefit and risk
  • 7.. Absorption and distribution of drugs
  • Translocation of drug molecules
  • Drug disposition
  • Drug absorption
  • Special drug delivery systems
  • 8.. Drug elimination and pharmacokinetics
  • Drug metabolism
  • Renal excretion of drugs and drug metabolites
  • Biliary excretion and enterohepatic circulation
  • Pharmacokinetics
  • Section 2. Chemical Mediators
  • 9.. Chemical mediators and the autonomic nervous system
  • Historical aspects
  • The peripheral nervous system
  • Some general principles of chemical transmission
  • Basic steps in neurochemical transmission: sites of drug action
  • 10.. Cholinergic transmission
  • Muscarinic and nicotinic actions of acetylcholine
  • Acetylcholine receptors
  • Physiology of cholinergic transmission
  • Effects of drugs on cholinergic transmission
  • 11.. Noradrenergic transmission
  • Classification of adrenoceptors
  • Physiology of noradrenergic transmission
  • Drugs acting on adrenoceptors
  • Drugs that affect noradrenergic neurons
  • 12.. Other peripheral mediators: 5-hydroxytryptamine and purines
  • 5-hydroxytryptamine
  • Purines
  • 13.. Peptides and proteins as mediators
  • General principles of peptide pharmacology
  • Biosynthesis and regulation of peptides
  • Peptide antagonists
  • Proteins and peptides as drugs
  • Concluding remarks
  • 14.. Nitric oxide
  • Biosynthesis of nitric oxide and its control
  • Degradation and carriage of nitric oxide
  • Effects of nitric oxide
  • Therapeutic approaches
  • Clinical conditions in which nitric oxide may play a part
  • 15.. Local hormones, inflammation and immune reactions
  • The components of the acute inflammatory reaction
  • The outcome of the inflammatory response
  • Mediators of inflammation and immune reactions
  • Current therapies based on manipulation of the immune response
  • Potential new therapies
  • 16.. Anti-inflammatory and immunosuppressant drugs
  • Non-steroidal anti-inflammatory drugs
  • Antagonists of histamine
  • Drugs used in gout
  • Antirheumatoid drugs
  • Immunosuppressant drugs
  • Possible future developments
  • Section 3. Drugs Affecting Major Organ Systems
  • 17.. The heart
  • Physiology of cardiac function
  • Drugs that affect cardiac function
  • 18.. The vascular system
  • Vascular structure and function
  • Control of vascular smooth muscle tone
  • Vasoactive drugs
  • Clinical uses of vasoactive drugs
  • 19.. Atherosclerosis and lipoprotein metabolism
  • Atherogenesis
  • Lipoprotein transport in the blood
  • Lipid-lowering drugs
  • 20.. Haemostasis and thrombosis
  • Blood coagulation
  • Drugs that act on the coagulation cascade
  • Platelet adhesion and activation
  • Fibrinolysis (thrombolysis)
  • 21.. The haemopoietic system
  • The haemopoietic system
  • Haematinic agents
  • Haemopoietic growth factors
  • 22.. The respiratory system
  • The regulation of respiration
  • Disorders of respiration and the drugs used in treatment
  • 23.. The kidney
  • Outline of renal function
  • The structure and function of the nephron
  • Drugs acting on the kidney
  • Drugs which alter the pH of the urine
  • Drugs which alter the excretion of organic molecules
  • 24.. The gastrointestinal tract
  • The innervation and the hormones of the gastrointestinal tract
  • Gastric secretion
  • Vomiting
  • The motility of the gastrointestinal tract
  • Drugs for chronic inflammatory bowel disease
  • Drugs affecting the biliary system
  • 25.. The endocrine pancreas and the control of blood glucose
  • Pancreatic islet hormones
  • Control of blood glucose
  • Diabetes mellitus and the drugs used in treatment
  • 26.. Obesity
  • The homeostatic mechanisms controlling energy balance
  • Obesity as a health problem and possible treatments
  • 27.. The pituitary and adrenal cortex
  • The pituitary and drugs used in therapy
  • The adrenal cortex and drugs used in therapy
  • 28.. The thyroid
  • Synthesis, storage and secretion of thyroid hormones
  • Regulation of thyroid function
  • Actions of the thyroid hormones
  • Transport and metabolism
  • Abnormalities of thyroid function
  • Drugs used in diseases of the thyroid
  • 29.. The reproductive system
  • Endocrine control of reproduction and modulating drugs
  • Drugs used for contraception
  • The uterus
  • Erectile dysfunction
  • 30.. Bone metabolism
  • Bone structure and composition
  • Bone remodelling
  • Disorders of bone and the drugs used in treatment
  • Section 4. The Nervous System
  • 31.. Chemical transmission and drug action in the central nervous system
  • Chemical signalling in the nervous system
  • Targets for drug action
  • Drug action in the central nervous system
  • The classification of psychotropic drugs
  • 32.. Amino acid transmitters
  • Excitatory amino acids
  • Glutamate
  • Gamma-aminobutyric acid
  • Glycine
  • 33.. Other transmitters and modulators
  • Noradrenaline
  • Dopamine
  • 5-Hydroxytryptamine
  • Acetylcholine
  • Purines
  • Histamine
  • Other CNS mediators
  • A final message
  • 34.. Neurodegenerative disorders
  • Mechanisms of neuronal death
  • Ischaemic brain damage
  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
  • Neurodegenerative prion diseases
  • 35.. General anaesthetic agents
  • Mechanism of action of anaesthetic drugs
  • The effects of anaesthetics on nervous system
  • Effects on the cardiovascular respiratory systems
  • Inhalation anaesthetics
  • Individual inhalation anaesthetics
  • Intravenous anaesthetic agents
  • 36.. Anxiolytic and hypnotic drugs
  • The nature of anxiety and measurement of anxiolytic activity
  • Classification of anxiolytic and hypnotic drugs
  • Benzodiazepines
  • Benzodiazepine antagonists
  • Buspirone
  • Barbiturates
  • Other potential anxiolytic drugs
  • 37.. Antipsychotic drugs
  • The nature of schizophrenia
  • Antipsychotic drugs
  • 38.. Drugs used in affective disorders
  • The nature of depression
  • Theories of depression
  • Antidepressant drugs
  • Electroconvulsive therapy
  • Clinical effectiveness of antidepressant treatments
  • Mood-stabilising drugs
  • 39.. Antiepileptic drugs
  • The nature of epilepsy
  • Mechanism of action of antiepileptic drugs
  • Antiepileptic drugs
  • Muscle spasm and centrally acting muscle relaxants
  • 40.. Analgesic drugs
  • Neural mechanisms of pain
  • Analgesic drugs
  • New approaches
  • 41.. CNS stimulants and psychotomimetic drugs
  • Convulsants and respiratory stimulants
  • Psychomotor stimulants
  • Psychotomimetic drugs
  • 42.. Drug dependence and drug abuse
  • The nature of drug dependence
  • Nicotine and tobacco
  • Ethanol
  • Cannabis
  • 43.. Local anaesthetics
  • Local anaesthetics
  • Other drugs that affect sodium channels
  • Section 5. Drugs Used in the Treatment of Infections and Cancer
  • 44.. Basic principles of chemotherapy
  • The molecular basis of chemotherapy
  • Resistance to antibacterial drugs
  • 45.. Antibacterial drugs
  • Antimicrobial agents that interfere with the synthesis or action of folate
  • Beta-lactam antibiotics
  • Antimicrobial agents affecting bacterial protein synthesis
  • Antimicrobial agents affecting topoisomerase II
  • Miscellaneous antibacterial agents
  • Antimycobacterial agents
  • Possible new antibacterial drugs
  • 46.. Antiviral drugs
  • Background information about viruses
  • The host-virus interaction
  • HIV and AIDS
  • Antiviral drugs
  • 47.. Antifungal drugs
  • Fungal infections
  • Drugs used for fungal infections
  • Potential new antifungal therapies
  • 48.. Antiprotozoal drugs
  • Host-parasite interactions
  • Malaria
  • Pneumocystis pneumonia and its treatment
  • Amoebiasis and amoebicidal drugs
  • Leishmaniasis and leishmanicidal drugs
  • Trypanosomiasis and trypanosomicidal drugs
  • Trichomoniasis and trichomonicidal drugs
  • Toxoplasmosis and toxoplasmocidal drugs
  • New approaches to antiprotozoal therapy
  • 49.. Anthelminthic drugs
  • Helminth infections
  • Anthelminthic drugs
  • Resistance to anthelminthic drugs
  • New approaches to anthelminthic therapy
  • 50.. Cancer chemotherapy
  • The pathogenesis of cancer
  • General principles of action of cytotoxic anticancer drugs
  • Drugs used in cancer chemotherapy
  • Resistance to anticancer drugs
  • Treatment schedules
  • Techniques for dealing with emesis and myelosuppression
  • Possible future strategies for cancer chemotherapy
  • Section 6. Special Topics
  • 51.. Individual variation and drug interaction
  • Effects of ethnicity
  • Effects of age
  • Effects of pregnancy
  • Genetic factors
  • Idiosyncratic reactions
  • Effects of disease
  • Drug interactions
  • 52.. Harmful effects of drugs
  • Types of adverse drug reaction
  • Drug toxicity
  • 53.. Gene therapy
  • Technical aspects
  • Safety
  • Therapeutic aspects
  • 54.. Drug discovery and development
  • The preclinical stages
  • Clinical development
  • Commercial aspects
  • A final note
  • Appendix
  • Index