Pharmacology /
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| Edition: | 4th ed. (USA ed.) |
|---|---|
| Imprint: | New York : Churchill Livingstone, c2001. |
| Description: | x, 839 p. : ill. ; 25 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4515899 |
Table of Contents:
- Section 1. General Principles
- 1.. What is pharmacology?
- Pharmacology in the 20th century
- 2.. How drugs act: general principles
- The binding of drug molecules to cells
- Desensitisation and tachyphylaxis
- 3.. How drugs act: molecular aspects
- Targets for drug action
- Receptor proteins
- Ion channels as drug targets
- Control of receptor expression
- Receptors and disease
- 4.. Cellular mechanisms: excitation, contraction and secretion
- Regulation of intracellular calcium levels
- Excitation
- Muscle contraction
- Release of chemical mediators
- Epithelial ion transport
- 5.. Cellular mechanisms: cell proliferation and apoptosis
- Cell proliferation
- Angiogenesis
- Apoptosis and cell removal
- Pathophysiological implications
- Therapeutic implications
- 6.. Method and measurement in pharmacology
- Bioassay
- Animal models of disease
- Clinical trials
- Balancing benefit and risk
- 7.. Absorption and distribution of drugs
- Translocation of drug molecules
- Drug disposition
- Drug absorption
- Special drug delivery systems
- 8.. Drug elimination and pharmacokinetics
- Drug metabolism
- Renal excretion of drugs and drug metabolites
- Biliary excretion and enterohepatic circulation
- Pharmacokinetics
- Section 2. Chemical Mediators
- 9.. Chemical mediators and the autonomic nervous system
- Historical aspects
- The peripheral nervous system
- Some general principles of chemical transmission
- Basic steps in neurochemical transmission: sites of drug action
- 10.. Cholinergic transmission
- Muscarinic and nicotinic actions of acetylcholine
- Acetylcholine receptors
- Physiology of cholinergic transmission
- Effects of drugs on cholinergic transmission
- 11.. Noradrenergic transmission
- Classification of adrenoceptors
- Physiology of noradrenergic transmission
- Drugs acting on adrenoceptors
- Drugs that affect noradrenergic neurons
- 12.. Other peripheral mediators: 5-hydroxytryptamine and purines
- 5-hydroxytryptamine
- Purines
- 13.. Peptides and proteins as mediators
- General principles of peptide pharmacology
- Biosynthesis and regulation of peptides
- Peptide antagonists
- Proteins and peptides as drugs
- Concluding remarks
- 14.. Nitric oxide
- Biosynthesis of nitric oxide and its control
- Degradation and carriage of nitric oxide
- Effects of nitric oxide
- Therapeutic approaches
- Clinical conditions in which nitric oxide may play a part
- 15.. Local hormones, inflammation and immune reactions
- The components of the acute inflammatory reaction
- The outcome of the inflammatory response
- Mediators of inflammation and immune reactions
- Current therapies based on manipulation of the immune response
- Potential new therapies
- 16.. Anti-inflammatory and immunosuppressant drugs
- Non-steroidal anti-inflammatory drugs
- Antagonists of histamine
- Drugs used in gout
- Antirheumatoid drugs
- Immunosuppressant drugs
- Possible future developments
- Section 3. Drugs Affecting Major Organ Systems
- 17.. The heart
- Physiology of cardiac function
- Drugs that affect cardiac function
- 18.. The vascular system
- Vascular structure and function
- Control of vascular smooth muscle tone
- Vasoactive drugs
- Clinical uses of vasoactive drugs
- 19.. Atherosclerosis and lipoprotein metabolism
- Atherogenesis
- Lipoprotein transport in the blood
- Lipid-lowering drugs
- 20.. Haemostasis and thrombosis
- Blood coagulation
- Drugs that act on the coagulation cascade
- Platelet adhesion and activation
- Fibrinolysis (thrombolysis)
- 21.. The haemopoietic system
- The haemopoietic system
- Haematinic agents
- Haemopoietic growth factors
- 22.. The respiratory system
- The regulation of respiration
- Disorders of respiration and the drugs used in treatment
- 23.. The kidney
- Outline of renal function
- The structure and function of the nephron
- Drugs acting on the kidney
- Drugs which alter the pH of the urine
- Drugs which alter the excretion of organic molecules
- 24.. The gastrointestinal tract
- The innervation and the hormones of the gastrointestinal tract
- Gastric secretion
- Vomiting
- The motility of the gastrointestinal tract
- Drugs for chronic inflammatory bowel disease
- Drugs affecting the biliary system
- 25.. The endocrine pancreas and the control of blood glucose
- Pancreatic islet hormones
- Control of blood glucose
- Diabetes mellitus and the drugs used in treatment
- 26.. Obesity
- The homeostatic mechanisms controlling energy balance
- Obesity as a health problem and possible treatments
- 27.. The pituitary and adrenal cortex
- The pituitary and drugs used in therapy
- The adrenal cortex and drugs used in therapy
- 28.. The thyroid
- Synthesis, storage and secretion of thyroid hormones
- Regulation of thyroid function
- Actions of the thyroid hormones
- Transport and metabolism
- Abnormalities of thyroid function
- Drugs used in diseases of the thyroid
- 29.. The reproductive system
- Endocrine control of reproduction and modulating drugs
- Drugs used for contraception
- The uterus
- Erectile dysfunction
- 30.. Bone metabolism
- Bone structure and composition
- Bone remodelling
- Disorders of bone and the drugs used in treatment
- Section 4. The Nervous System
- 31.. Chemical transmission and drug action in the central nervous system
- Chemical signalling in the nervous system
- Targets for drug action
- Drug action in the central nervous system
- The classification of psychotropic drugs
- 32.. Amino acid transmitters
- Excitatory amino acids
- Glutamate
- Gamma-aminobutyric acid
- Glycine
- 33.. Other transmitters and modulators
- Noradrenaline
- Dopamine
- 5-Hydroxytryptamine
- Acetylcholine
- Purines
- Histamine
- Other CNS mediators
- A final message
- 34.. Neurodegenerative disorders
- Mechanisms of neuronal death
- Ischaemic brain damage
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
- Neurodegenerative prion diseases
- 35.. General anaesthetic agents
- Mechanism of action of anaesthetic drugs
- The effects of anaesthetics on nervous system
- Effects on the cardiovascular respiratory systems
- Inhalation anaesthetics
- Individual inhalation anaesthetics
- Intravenous anaesthetic agents
- 36.. Anxiolytic and hypnotic drugs
- The nature of anxiety and measurement of anxiolytic activity
- Classification of anxiolytic and hypnotic drugs
- Benzodiazepines
- Benzodiazepine antagonists
- Buspirone
- Barbiturates
- Other potential anxiolytic drugs
- 37.. Antipsychotic drugs
- The nature of schizophrenia
- Antipsychotic drugs
- 38.. Drugs used in affective disorders
- The nature of depression
- Theories of depression
- Antidepressant drugs
- Electroconvulsive therapy
- Clinical effectiveness of antidepressant treatments
- Mood-stabilising drugs
- 39.. Antiepileptic drugs
- The nature of epilepsy
- Mechanism of action of antiepileptic drugs
- Antiepileptic drugs
- Muscle spasm and centrally acting muscle relaxants
- 40.. Analgesic drugs
- Neural mechanisms of pain
- Analgesic drugs
- New approaches
- 41.. CNS stimulants and psychotomimetic drugs
- Convulsants and respiratory stimulants
- Psychomotor stimulants
- Psychotomimetic drugs
- 42.. Drug dependence and drug abuse
- The nature of drug dependence
- Nicotine and tobacco
- Ethanol
- Cannabis
- 43.. Local anaesthetics
- Local anaesthetics
- Other drugs that affect sodium channels
- Section 5. Drugs Used in the Treatment of Infections and Cancer
- 44.. Basic principles of chemotherapy
- The molecular basis of chemotherapy
- Resistance to antibacterial drugs
- 45.. Antibacterial drugs
- Antimicrobial agents that interfere with the synthesis or action of folate
- Beta-lactam antibiotics
- Antimicrobial agents affecting bacterial protein synthesis
- Antimicrobial agents affecting topoisomerase II
- Miscellaneous antibacterial agents
- Antimycobacterial agents
- Possible new antibacterial drugs
- 46.. Antiviral drugs
- Background information about viruses
- The host-virus interaction
- HIV and AIDS
- Antiviral drugs
- 47.. Antifungal drugs
- Fungal infections
- Drugs used for fungal infections
- Potential new antifungal therapies
- 48.. Antiprotozoal drugs
- Host-parasite interactions
- Malaria
- Pneumocystis pneumonia and its treatment
- Amoebiasis and amoebicidal drugs
- Leishmaniasis and leishmanicidal drugs
- Trypanosomiasis and trypanosomicidal drugs
- Trichomoniasis and trichomonicidal drugs
- Toxoplasmosis and toxoplasmocidal drugs
- New approaches to antiprotozoal therapy
- 49.. Anthelminthic drugs
- Helminth infections
- Anthelminthic drugs
- Resistance to anthelminthic drugs
- New approaches to anthelminthic therapy
- 50.. Cancer chemotherapy
- The pathogenesis of cancer
- General principles of action of cytotoxic anticancer drugs
- Drugs used in cancer chemotherapy
- Resistance to anticancer drugs
- Treatment schedules
- Techniques for dealing with emesis and myelosuppression
- Possible future strategies for cancer chemotherapy
- Section 6. Special Topics
- 51.. Individual variation and drug interaction
- Effects of ethnicity
- Effects of age
- Effects of pregnancy
- Genetic factors
- Idiosyncratic reactions
- Effects of disease
- Drug interactions
- 52.. Harmful effects of drugs
- Types of adverse drug reaction
- Drug toxicity
- 53.. Gene therapy
- Technical aspects
- Safety
- Therapeutic aspects
- 54.. Drug discovery and development
- The preclinical stages
- Clinical development
- Commercial aspects
- A final note
- Appendix
- Index
