Enzyme technologies for pharmaceutical and biotechnological applications /
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| Imprint: | New York : Marcel Dekker, c2001. |
|---|---|
| Description: | xv, 611 p. : ill. ; 24 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4586838 |
Table of Contents:
- Preface
- Contributors
- I.. Biosynthesis
- 1.. [delta]-(L-[alpha]-Aminoadipyl)-L-Cysteinyl-D-Valine Synthetase as a Model Tripeptide Synthetase
- 2.. Metabolic Engineering for Cephalosporin C Yield Improvement and Production of Intermediates
- 3.. Bioconversion of Penicillins to Cephalosporins
- 4.. Direct Fermentative Production of Acyltylosins by Genetically Engineered Strains of Streptomyces fradiae
- 5.. Engineering Streptomyces avermitilis for the Production of Novel Avermectins: Mutant Design and Titer Improvement
- II.. Biocatalysis
- 6.. Biocatalytic Syntheses of Chiral Intermediates for Antihypertensive Drugs
- 7.. Cloning, Structure, and Activity of Ketone Reductases from Baker's Yeast
- 8.. Cross-Linked Enzyme Crystals: Biocatalysts for the Organic Chemist
- 9.. Enzymatic Deacylation of Echinocandins and Related Antifungal Agents
- III.. Screening/Optimization
- 10.. Roles of Enzymes in Antibacterial Drug Discovery
- 11.. Penicillin-Binding Proteins as Antimicrobial Targets: Expression, Purification, and Assay Technologies
- 12.. Development of a High-Throughput Screen for Streptococcus pneumoniae UDP-N-Acetylmuramoyl-Alanine: D-Glutamate Ligase (MurD) for the Identification of MurD Inhibitors
- 13.. Purification and Assay Development for Human Rhinovirus Proteases
- 14.. Screening for Parasiticides Using Recombinant Microorganisms
- 15.. Screening for Inhibitors of Lipid Metabolism
- 16.. Design and Development of a Selective Assay System for the Phospholipase A[subscript 2] Superfamily
- IV.. Emerging Technologies
- 17.. Understanding and Exploiting Bacterial Polyketide Synthases
- 18.. Polyketide Synthases: Analysis and Use in Synthesis
- 19.. Enzymatic Synthesis of Fungal N-Methylated Cyclopeptides and Depsipeptides
- 20.. New Strategies for Target Identification, Validation, and Use of Enzymes in High-Throughput Screening
- 21.. Use of Genomics for Enzyme-Based Drug Discovery
- 22.. Assigning Precise Function to Genes
- 23.. Redesigning Binding and Catalytic Specificities of Enzymes
- 24.. Proteomics: Chromatographic Fractionation Prior to Two-Dimensional Polyacrylamide Gel Electrophoresis for Enrichment of Low-Abundance Proteins to Facilitate Identification by Mass Spectrometric Methods
- Index
