Molecular mechanism and therapeutics of amyotrophic lateral sclerosis : proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22-24 September 2000 /
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| Meeting name: | International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis (2000 : Okayama-shi, Japan) |
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| Edition: | 1st ed. |
| Imprint: | Amsterdam ; New York : Elsevier, 2001. |
| Description: | xii, 382 p. : ill. (some col.) ; 25 cm. |
| Language: | English |
| Series: | Excerpta Medica international congress series, 0531-5131 ; 1221 International congress series ; no. 1221. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4592889 |
| Summary: | This volume covers the latest findings on the molecular mechanism and therapeutics of amyotrophic lateral sclerosis (ALS), including important research on 1) pathological characteristics and epidemiology of ALS, 2) selective vulnerability of spinal motor neurons, 3) genetic abnormality of ALS and neurotrophin, 4) mechanism of motor neuron death and glutamate toxicity, 5) motor axon, axonal transport, neurofilament, and glycation, 6) basic therapeutic approach, and 7) clinical therapeutic approach. The surprising discovery of Cu/Zn superoxide dismutase (SOD1) gene mutations in a part of familial ALS in 1993 has had a strong impact on all neuroscientists and clinicians dealing with this disease. This volume aims to help them to progress their future basic and clinical investigations, and to enhance strong scientific collaboration in elucidating the molecular mechanism and discovering the essential therapeutics of the disease. |
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| Physical Description: | xii, 382 p. : ill. (some col.) ; 25 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 0444506136 |
| ISSN: | 0531-5131 ; |
