Molecular mechanism and therapeutics of amyotrophic lateral sclerosis : proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22-24 September 2000 /
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| Meeting name: | International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis (2000 : Okayama-shi, Japan) |
|---|---|
| Edition: | 1st ed. |
| Imprint: | Amsterdam ; New York : Elsevier, 2001. |
| Description: | xii, 382 p. : ill. (some col.) ; 25 cm. |
| Language: | English |
| Series: | Excerpta Medica international congress series, 0531-5131 ; 1221 International congress series ; no. 1221. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4592889 |
Table of Contents:
- Preface
- Acknowledgements
- 1.. Pathological Characteristics and an Epidemiology of ALS
- Pyramidal tract pathology in amyotrophic lateral sclerosis--axon staining reveals degeneration undisclosed on myelin staining
- Molecular pathology of axonal spheroids in ALS
- Basophilic cytoplasmic inclusions in amyotrophic lateral sclerosis
- Expression of cathepsins in the motor neurons of amyotrophic lateral sclerosis
- Epidemiology of Motor Neuron Disease in Miyakonojo Basin, Kyushu, Japan
- Intracytoplasmic inclusions with overexpressed mutant SOD1 gene
- 2.. Selective Vulnerability of Spinal Motor Neurons
- Induction of Cell cycle dependent proteins in spinal motor neurons
- Apoptosis of spinal motor neuron after ischemia
- Motor neuron apoptosis by glutamate
- Subcellular localization of Cu,Zu-SOD and its role in the pathogenesis of FALS
- Zinc-deficient superoxide dismutase: A possible mechanism for ALS
- ROS/RNS/dicarbonyl stress to spinal motor neurons in vitro
- An experimental model of Kii-ALS. A chronic low-CaMg high-Al diet induces neuronal loss and skin changes
- Establishment of local cooling model against transient spinal cord ischemia
- 3.. Genetic Abnormality of ALS and Neurotrophin
- SOD1 mutation and clinical features of familial amyotrophic lateral sclerosis
- A two-base deletion of SOD1 gene in a Japanese FALS family
- A family with a novel SOD1 gene mutation
- Familial ALS with a novel homozygous mutation of Cu/Zn SOD gene
- CAG/CTG repeat expansions are not commonly involved in the pathogenesis of amyotrophic lateral sclerosis
- Association study in [alpha]-synuclein polymorphism in sporadic amyotrophic lateral sclerosis
- The response of motor neurons to brain-derived neurotrophic factor
- GDNF and RET induction in motor neurons after spinal cord ischemia
- 4.. Mechanism of Motor Neuron Death and Glutamate Toxicity
- Reduction of survival signal-related protein immunoreactivities in spinal motoneurons of transgenic ALS model
- Downregulation of GluR2 subunit in spinal motoneurons following ventral root avulsion in adult rats
- Mutations in the glutamate transporter EAAT2 gene
- Molecular changes of AMPA receptor subunits in ALS spinal cord
- Motor neuron death in GluR2 receptor knockout
- Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: Implications for selective vulnerability of motor neurons
- Glutamate enhances caspase-3 and TUNEL immunoreactivities in cultured rat spinal motor neurons
- Iron and oxidative stress in nigral neurons of Guamanian ALS/PDC: chemical state imaging using synchrotron radiation
- 5.. Motor Axon, Axonal Transport, Neurofilament, and Glycation
- Gangliosides of isolated bovine spinal motoneurons
- Impaired axonal transport in transgenic ALS model
- Abnormal glycation in ALS
- Formation of advanced glycation endproduct (AGE)-modified superoxide dismutase 1 (SOD1) is common to familial amyotrophic lateral sclerosis (FALS) patients with SOD1 gene mutation and G85R transgenic mice
- Transgenic mice expressing an H46R mutant of human Cu/Zn superoxide dismutase
- Increases in mRNA expression for T [alpha]1-tubulin following systemic administration of kainate in rat
- 6.. Basic Therapeutic Approach
- Neurotrophic factor delivery by encapsulated cell grafting technique
- Potential of XIAP for motor neuron rescue
- Amelioration of motor neuron disease model with molecular chaperones - with special reference to spinal and bulbar muscular atrophy
- Neurotrophic factor gene therapy for motor neuron disease
- Protective effect of cyclic GMP against acute, but not against chronic oxidative injury of spinal motor neurons
- 7.. Clinical Therapeutic Approach
- Treatment of wobbler mice with free radical scavenger
- Potential of immunophilin-ligands for neuronal cell rescue
- Expression of adenovirus-mediated E. coli lacZ gene in skeletal muscles and spinal motoneurons of mutant SOD1 transgenic mice
- Adenoviral GDNF gene therapy for injured adult motoneurons
- BDNF treatment in Amyotrophic Lateral Sclerosis
- What is the contribution of riluzole to the treatment of ALS?
- Index of authors
