Neural transplantation an introduction /
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| Author / Creator: | Freed, William J. |
|---|---|
| Imprint: | Cambridge, Mass. : MIT Press, 2000. |
| Description: | xii, 561 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Cellular and molecular neuroscience Cellular and molecular neuroscience series |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4597188 |
Table of Contents:
- Preface
- Acknowledgments
- I. Introduction
- 1. Introduction to Transplantation in the Nervous System
- What Is Brain Tissue Transplantation?
- The Chronic Nature of Neurological Disease
- 2. Brain Structure and Development
- Components
- Sensory Input
- Information Processing
- Effectors
- Cellular Components
- Types of Circuits
- Conclusion
- Further Reading
- II. General And Background Information
- 3. History of Neural Transplantation
- The Earliest Experiment
- Subsequent Early Studies
- Experiments on Specific Systems
- Further Reading
- 4. Transplants and How They Are Used
- How Is Tissue Transplanted into the Brain?
- Maturational State of the Donor Cells and the Host
- How Can Cells Be Used to Repair the Brain?
- Diseases and Possibilities Not Covered in This Book
- Grafts in Epilepsy
- Disorders of Central Nervous System Demyelination
- Immunology
- Further Reading
- 5. Control Groups and Experiments
- Experimental Design
- Between-Groups Designs and Control Groups
- 6. Regulations and Guidelines for Fetal Tissue Transplantation
- Fetal Tissue Research and Use
- Fetal Tissue Use Regulations
- Possible Problems
- Regulation of Transplantation Surgery Research
- Further Reading
- 7. Mind Control and Other Things to Worry About
- Can Brain Transplants Be Used to Alter Personality?
- Have Neural Transplants Already Produced Personality Changes?
- What Might Be Responsible for Unexpected Personality Changes After Brain Grafts?
- Can Brain Grafts Be Used Intentionally to Produce Personality Changes?
- Limits
- Society and Regulation
- Two Interesting Things to Think About
- A Prisoner Dilemma
- The Anencephalic Birth
- III. Parkinson's Disease
- 8. Neural Systems and Parkinson's Disease
- Parkinson's Disease
- Neural Systems
- Current Animal Behavioral Models
- Studies in Rodents
- Studies in Monkeys
- Why Not Just Pump Dopamine into the Brain?
- Further Reading
- 9. Neural Transplantation in Parkinson's Disease: A Brief Synopsis
- 10. Fetal Brain Tissue Transplantation in Parkinson's Disease: Experiments in Animals
- Basic Studies in Rodents
- Donor Tissue Age: Experiments in Rats
- Donor Age Requirement: Data from Human-to-Rat Transplants
- Time Course for Improvement
- Behavioral Tests
- Method of Transplantation and Transplantation Sites
- Increasing Graft Efficacy: Growth Factors and Transplants in the Substantia Nigra
- Conclusions
- Further Reading
- 11. Adrenal Medulla Transplantation
- Anatomy
- Cell Types and Functions of the Adrenal Gland
- Transplantation
- How Do Adrenal Medulla Grafts Work?
- Trophic Effects of Adrenal Medulla Grafts
- Transplantation Site
- Clinical Studies
- Clinical Evaluations -- A Digression
- Now Back to the Clinical Studies
- Postmortem Findings
- Conclusions
- Further Reading
- 12. Studies in Subhuman Primates
- Bankiewicz, Plunkett, and Coworkers
- Experiments of J. Taylor and Associates
- Further Reading
- 13. Fetal Brain Tissue Transplantation in Parkinson's Disease: Clinical Studies
- University of South Florida Study
- Yale University Study
- Studies from Lund, Sweden
- MPTP-Induced Parkinsonism
- Denver, Colorado
- Denver/New York Collaborative Study
- Mexico City (Madrazo and Coworkers)
- Havana, Cuba
- Birmingham, England
- Warsaw, Poland
- Burlington, Massachusetts, Studies with Pig Donor Tissue
- Conclusions
- Further Reading
- IV. Using Transplants To Influence Localized Brain Functions
- 14. Pain
- Further Reading
- 15. Hypothalamus and Pituitary
- Sexual Function and Differentiation
- Blood Pressure Regulation
- Immune Mechanisms
- Circadian Rhythms
- Conclusion
- Further Reading
- 16. The Cerebral Cortex and Stroke
- Transplantation of the Cerebral Cortex in Lower Animals
- Selective Cortical Injury
- Can Cortical Transplants Be Used in Human Stroke Patients?
- Further Reading
- V. Circuit Reconstruction
- 17. Huntington's Disease
- Background
- Transplantation and Reconstruction of Circuits
- Experiments in Rodents
- Connections of Striatal Grafts
- Possibilities for Transplantation to Produce Trophic Effects and Prevent Neuronal Loss
- Nonhuman Primate Models
- Prospects for Clinical Studies
- Speculation
- Further Reading
- 18. Spinal Cord
- More Details on Basic Research: Experiments by Kao and Coworkers
- Albert Aguayo
- Martin Schwab and Lisa Schnell
- Studies by Richard Bunge and Mary Bunge
- Transplantation of Fetal CNS Tissues into the Spinal Cord
- Transplants of Neurons from Above the Spinal Cord
- Fetal Spinal Cord Grafts
- Anatomical Observations of Spinal Cord Grafts
- Kunkel-Bagden and Bregman 1990 Study
- Iwashita et al. 1994 Study
- Stokes and Reier 1992 Study
- Cheng, Cao, and Olson 1996 Study
- Li, Field, and Raisman 1997 Study
- Conclusions
- Bridging the Gap
- Growth Within the Spinal Cord
- Relay Function and Reorganization
- Combinations of Methods
- Conclusions
- Further Reading
- 19. Visual System
- Intracerebral Grafts of Retinal Tissue
- Transplantation of Retinal Cells to the Damaged Retina
- Conclusions
- Further Reading
- VI. Genetic Engineering And Technology Of The Future
- 20. Introduction to Genetic Engineering and Neural Transplantation
- What Can We Expect in the Future?
- Genetic Engineering
- Transferring DNA into Cells
- Gene Therapy
- Genetic Engineering and Neural Transplantation
- For Further Reading
- 21. Growing Cells in Culture: Stem and Progenitor Cells
- Terminology and Orientation
- What Are Stem Cells, and What Cells Are Immortal?
- Dopamine Neurons from Progenitor Cell Cultures
- Human Neural Stem Cells
- Conclusions
- Further Reading
- 22. Growing Cells in Culture: Immortal Cell Lines
- What Is an "Immortal Cell Line"?
- Why Do We Want to Use Immortal Cell Lines?
- How Can We Intentionally Produce Immortal Cell Lines?
- Tumor Cells
- Immortalized Cell Lines Produced By Genetic Transfer of Oncogenes
- Creating Immortal Cell Lines: Two Strategies
- Type I Experiments
- Type II Experiments
- Genetically Altered Mice
- Human Cell Lines
- Further Reading
- 23. Genetically Modified Cells for Producing Neurotrophic Factors and Neurotransmitters
- What Kinds of Cells Can Be Used for Starting Material?
- Growth Factor Delivery by Genetically Modified Cells
- Genetic Engineering of Cells to Make Neurotransmitters: L-DOPA in Parkinson's Disease Models
- g-Aminobutyric Acid (GABA)
- Conclusion
- Further Reading
- 24. Direct Gene Transfer
- Applications
- Further Reading
- VII. Conclusions
- 25. Conclusions
- Replacing the Brain -- All at Once or a Little at a Time
- Brain Development and Integrity, and a Model
- Building New Brains or Artificial Brains
- Limitations of Brain Repair
- Conclusion
- Glossary
- References
- Index