Recombinant antibodies for cancer therapy : methods and protocols /
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| Imprint: | Totowa, N.J. : Humana Press, c2003. |
|---|---|
| Description: | xiv, 481 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Methods in molecular biology ; v. 207 Methods in molecular biology (Clifton, N.J.) ; v. 207. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4756221 |
Table of Contents:
- Preface
- Contributors
- Part I.. Introduction
- 1. Generation of Antibody Molecules Through Antibody Engineering
- 2. Application of Recombinant Antibodies in Cancer Patients
- Part II.. Hybridoma-Derived Antibodies
- 3. DNA Immunization as a Means to Generate Antibodies to Proteins
- 4. Chimerization of a Monoclonal Antibody for Treating Hodgkin's Lymphoma
- 5. Humanization of Monoclonal Antibodies by CDR Grafting
- Part III.. Recombinant Antibody Fragments from Phagemid-Displayed Antibody Repertoires
- 6. Generation and Screening of a Modular Human scFv Expression Library from Mulitple Donors
- 7. Construction of Semisynthetic Antibody Libraries
- 8. Single-Domain V[subscript H] Antibody Fragments from a Phage Display Library
- 9. Isolation of Human Fab Fragments Against Ovarian Carcinoma Using Guided Selection
- 10. Human Recombinant Fab Antibodies with T-Cell Receptor-Like Specificities Generated from Phage Display Libraries
- 11. Engineering Hot Spots for Affinity Enhancement of Antibodies
- 12. Simultaneous Humanization and Affinity Optimization of Monoclonal Antibodies
- 13. Tailoring Kinetics of Antibodies Using Focused Combinatorial Libraries
- Part IV.. Antibody Fragments with Additional Properties
- 14. Engineering scFvs for Improved Stability
- 15. Recombinant Single-Chain and Disulfide-Stabilized Fv Immunotoxins for Cancer Therapy
- 16. Generation of Recombinant Immunotoxins for Specific Targeting of Tumor-Related Peptides Presented by MHC Molecules
- 17. Construction and Characterization of RNase-Based Targeted Therapeutics
- 18. Bispecific Diabodies for Cancer Therapy
- 19. Generation and Characterization of Bispecific Tandem Diabodies for Tumor Therapy
- 20. Generation of Recombinant Multimeric Antibody Fragments for Tumor Diagnosis and Therapy
- 21. Construction and Characterization of Minibodies for Imaging and Therapy of Colorectal Carcinomas
- 22. Generation, Expression, and Monitoring of Recombinant Immune Receptors for Use in Cellular Immunotherapy
- 23. Tailoring Natural Effector Functions: Antibody Engineering Beyond Humanization
- 24. Single-Chain Fv-Based Affinity Purification of the Cellular Stress Protein gp96 for Vaccine Development
- 25. Recombinant Adenoviruses for In Vivo Expression of Antibody Fragments
- Part V.. Large Scale Production of Recombinant Antibodies for Clinical Application
- 26. Production of Antibody Fragments in a Bioreactor
- 27. Large Scale Production of Recombinant Antibodies by Utilizing Cellulose-Binding Domains
- 28. Production of Tumor-Specific Antibodies in Tobacco
- Index
