Microbial DNA and host immunity /

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Bibliographic Details
Imprint:Totowa, N.J. : Humana Press, c2002.
Description:xvii, 408 p. : ill. ; 23 cm.
Language:English
Subject:
Format: E-Resource Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/4781353
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Other authors / contributors:Raz, Eyal, MD
ISBN:1588290220 (alk. paper)
Notes:Includes bibliographical references and index.
Table of Contents:
  • Preface
  • Contributors
  • Part I. Introduction
  • 1. Immunostimulatory DNA: An Overview
  • 2. Historical Perspectives
  • Part II. Receptors and Signaling
  • 3. Signal Transduction Pathways Activated By CpG-DNA
  • 4. A Novel Toll-Like Receptor that Recognizes Bacterial DNA
  • 5. Activation of Innate Immunity by Microbial Nucleic Acids
  • 6. Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG
  • Part III. Cell Activation
  • 7. Activation of NK Cell By Immunostimulatory Oligo-DNA in Mouse and Human
  • 8. Regulation of Antigen Presenting Cell Function by CpG DNA
  • 9. Activation of B Cells by CpG Motifs in Bacterial DNA
  • 10. IFN-Dependent Pathways for Stimulation of Memory CD8[superscript +] Cells
  • 11. Cross-Priming of CD8[superscript +] T Cells by Immunostimulatory Sequence DNA
  • Part IV. Vaccination Strategies
  • 12. The Th1 Adjuvant Effect of Immunostimulatory (ISS) DNA Sequences
  • 13. Immunostimulatory DNA Prepriming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses
  • 14. Protein-Immunostimulatory DNA-Conjugate: A Novel Immunogen
  • 15. Immunostimulatory DNA Sequence-Based Mucosal Vaccines
  • 16. Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence by Liposomal Delivery
  • 17. Immunostimulatory Sequences in Plasmid Vectors
  • Part V. Applications--Infectious Disease
  • 18. Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B
  • 19. Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine?
  • 20. Immunoprotective Activity of CpG Oligonucleotides
  • 21. Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection
  • Part VI. Applications--Allergy
  • 22. DNA-Based Immunotherapeutics For Allergic Disease
  • 23. Immunostimulatory DNA for Allergic Asthma
  • 24. CpG Oligodeoxynucleotides in Asthma
  • 25. Modulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence Oligonucleotides
  • Part VII. Applications--Cancer
  • 26. CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma
  • Part VIII. Inflammation and Autoimmunity
  • 27. The Antigenicity of Bacterial DNA
  • 28. Inflammatogenic Properties of Immunostimulatory DNA Sequences
  • 29. The Role of Immunostimulatory DNA Sequences in Arthritis
  • 30. Effects of Immunostimulatory DNA Oligonucleotides on Experimental Colitis
  • Part IX. Saffty Considerations
  • 31. CpG ODN--Safety Considerations
  • Index