Proteoglycans in lung disease /
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| Imprint: | New York : M. Dekker, c2003. |
|---|---|
| Description: | xxi, 459 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Lung biology in health and disease ; v. 168 |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4807283 |
Table of Contents:
- Series Introduction
- Preface
- Contributors
- 1.. Proteoglycans of the Lung
- I.. Introduction
- II.. Proteoglycans
- III.. Glycosaminoglycans
- IV.. Proteoglycan Metabolism
- V.. Extracellular Matrix Proteoglycans
- VI.. Basement Membrane Proteoglycans
- VII.. Cell Surface Proteoglycans
- VIII.. Intracellular Proteoglycans
- IX.. Conclusions
- References
- 2.. Hyaluronan in Lung Function: An Overview
- I.. Introduction
- II.. Hyaluronan in Normal Lung Development
- III.. Hyaluronan in Diseased Lung
- IV.. Hyaluronan in Models of Lung Injury and Repair
- V.. Hyaluronan Depolymerization in Lung Injury
- VI.. CD44 Is the Major Hyaluronan Receptor in the Lung
- VII.. Functions of Hyaluronan in Lung Injury and Repair
- VIII.. Conclusions
- References
- 3.. Morphological Tools for Studying Lung Proteoglycans
- I.. Introduction
- II.. Histochemistry for Proteoglycans
- III.. Enzymatic Treatment
- IV.. Immunohistochemistry
- V.. Probe for Hyaluronan
- VI.. Pulmonary Vascular Hypertension
- VII.. "In Situ" Hybridization
- VIII.. Electron Microscopy
- IX.. Proteoglycan Morphometry
- X.. Other Types of Microscopy
- XI.. Magnetic Resonance Imaging
- XII.. Summary
- References
- 4.. Proteoglycans, Lung Physiology, and Mechanical Strain
- I.. Introduction
- II.. Proteoglycans in the Lung
- III.. Role of Proteoglycans in Determining Lung Tissue Mechanical Behavior
- IV.. Effects of Mechanical Strain on Proteoglycans
- V.. Implications for Lung Disease
- VI.. Conclusion
- References
- 5.. Hyaluronan and Its Receptors in Lung Health and Disease
- I.. Introduction
- II.. Hyaluronan
- III.. Hyaladherins
- IV.. HA and Its Receptors in Wound Healing
- V.. HA and Its Receptors in Inflammation
- VI.. HA and Its Receptors in Vasculogenesis and Angiogenesis
- VII.. HA and Its Receptors in Lung Health and Disease
- VIII.. Summary and Conclusions
- References
- 6.. Hyaluronan and Hyaladherin Signaling in the Lung
- I.. Introduction
- II.. Hyaluronan
- III.. Hyaladherins
- IV.. Hyaluronan and Lung Diseases
- V.. A Role for HA in Regulating Leukocyte Trafficking and Macrophage Activation
- VI.. Summary
- References
- 7.. Hyaluronan in Malignant Mesothelioma
- I.. Introduction
- II.. Hyaluronan
- III.. HA in Malignant Mesothelioma
- IV.. HA Analysis
- V.. Alterations of HA in Serum
- VI.. Immunohistochemical Characterization of HA-Producing Malignant Pleural Mesothelioma
- VII.. HA as a Prognostic Factor in MPM
- VIII.. Serum HA Versus Tumor Volume
- IX.. Conclusions
- References
- 8.. Matrix Proteoglycans in Development of Pulmonary Edema
- I.. The Pulmonary Interstitial Space
- II.. Lung Proteoglycans and Hyaluronan
- III.. Pulmonary Interstitial Pressure
- IV.. Microvascular Fluid Exchanges
- V.. P[subscript ip] Pulmonary in the Transition Toward Hydraulic and Lesional Edema
- VI.. Lung Proteoglycans During Developing of Interstitial Edema
- VII.. Proteoglycans in Interstitial Lung Edema Induced by Hypoxia Exposure
- VIII.. An Example of "Spontaneous Recovery" from Lung Edema: The Newborn Lung
- IX.. Conclusions
- References
- 9.. The Role of Small Proteoglycans in the Formation of Fibrosis
- I.. Introduction
- II.. Small Proteoglycans: A Family of Structurally Different Macromolecules
- III.. Impact of Small Proteoglycans on Matrix Assembly
- IV.. Core Proteins of Small Proteoglycans: Interactions with Cytokines and Their Receptors
- V.. Polysaccharide Substitution of Small Proteoglycans
- VI.. Metabolism of the Small Proteoglycans
- VII.. Different Pathological Disorders Involving the Small Proteoglycans
- VIII.. Normal Physiology of the Lung
- IX.. Small Proteoglycans and Lung Pathology
- X.. Conclusions and Future Perspectives
- References
- 10.. Versican in the Cell Biology of Pulmonary Fibrosis
- I.. Introduction
- II.. Proteoglycans
- III.. Functions of Versican in Provisional Matrix
- IV.. Platelet-Derived Growth Factor and Transforming Growth Factor Beta
- V.. Parallels Between Pulmonary Fibrosis and Wound Healing in Other Systems
- VI.. Conclusions
- References
- 11.. Decorin in Asthma
- I.. Introduction
- II.. Molecular Biology of Decorin
- III.. Interactions Between Decorin and the Extracellular Matrix (ECM)
- IV.. Interactions Between Decorin and TGF[beta]
- V.. Airway Fibrosis in Asthma
- VI.. Expression of Decorin and TGF[beta] in Normal and Asthmatic Airways
- VII.. Therapeutic Implications
- References
- 12.. Role of Proteoglycans in the Development and Pathogenesis of Emphysema
- I.. Introduction
- II.. Pulmonary Interstitium in Emphysema
- III.. Proteoglycans in Emphysema
- IV.. Pathogenesis of Pulmonary Emphysema
- V.. Conclusions
- References
- 13.. Proteoglycans in Normal and Pathological Bronchial Mucus
- I.. Introduction
- II.. Cellular Sources of Bronchial Mucus
- III.. Proteoglycans in Normal Bronchial Mucus
- IV.. Bronchoalveolar Lavage (BAL) from Healthy Volunteers
- V.. In Vitro Culture of Airway Mucosal Explants
- VI.. Glycoconjugates Secreted by Airway Epithelial Cells in Culture
- VII.. Proteoglycans in Pathological Bronchial Mucus
- References
- 14.. Vascular Proteoglycans
- I.. Introduction
- II.. Proteoglycans: Structure and Classification
- III.. Proteoglycans Identified in Blood Vessels
- IV.. Functions of Proteoglycans Found in the Vascular Wall
- V.. Proteoglycans in Vascular Diseases
- VI.. Conclusion
- References
- 15.. Degradation of Lung Matrix Proteoglycans in Bronchiectasis
- I.. Introduction
- II.. Central Role of the Neutrophil in Bronchiectasis
- III.. Neutrophil Elastase and Antielastases
- IV.. Degradation of Lung Matrix Proteoglycans
- V.. Summary
- References
- 16.. Effect of Hypoxia on Glycosaminoglycan Synthesis by Lung Cells
- I.. Introduction
- II.. Role of Glycosaminoglycans in Lung Cell Biology
- III.. Effect of Hypoxia on Glycosaminoglycans
- IV.. Glycosaminoglycans as New Therapeutic Agents or Targets
- References
- 17.. Integrins, Proteoglycans, and Lung Disease
- I.. Introduction
- II.. Cellular Function of Integrins
- III.. Integrins in Common Lung Diseases
- References
- 18.. Heparin as a Potential Therapeutic Agent to Reverse Vascular Remodeling
- I.. Introduction
- II.. Heparin Structure
- III.. Low-Molecular-Weight Heparins
- IV.. Differences in the Structure of Heparin and Heparan Sulfate
- V.. Heparin and Pulmonary Hypertension
- VI.. Antiproliferative Activity of Heparin and Its Derivatives
- VII.. Summary and Conclusion
- References
- Author Index
- Subject Index
