Brain ischemia /
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| Author / Creator: | Gusev, E. I. |
|---|---|
| Imprint: | New York : Kluwer Academic/Plenum Publishers, c2003. |
| Description: | xiv, 382 p. : ill. ; 24 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4909038 |
Table of Contents:
- Introduction
- Part I.. Mechanisms of Ischemic Brain Damage
- Chapter 1.. Hemodynamic Events Associated with Acute Focal Brain Ischemia and Reperfusion. Ischemic Penumbra
- Chapter 2.. Cellular Reactions in Response to Acute Focal Brain Ischemia
- Chapter 3.. Energy Failure Induced by Brain Ischemia
- Chapter 4.. The Glutamate-Calcium Cascade
- 4.1.. The induction stage: energy-dependent ion pump failure and glutamate excitotoxicity
- 4.1.1.. Cerebrospinal fluid levels of neurotransmitter amino acids in patients with acute ischemic stroke
- 4.1.2.. Regulation of concentration of excitatory amino acids in the synaptic cleft
- 4.1.3.. Glutamate receptors and mechanisms of brain ischemia
- 4.2.. The amplification stage: intracellular accumulation of calcium ions, spreading glutamate release, spreading depression waves
- 4.3.. The expression stage: calcium-induced activation of intracellular enzymes, oxidative stress and abundant NO production, and accumulation of low molecular weight cytotoxic substances
- 4.3.1.. CSF levels of thiobarbituric acid reactive substances, SOD, cGMP, and N-acetylneuraminic acid in patients with ischemic stroke
- Chapter 5.. Metabolic Acidosis and Ischemic Damage
- Chapter 6.. Delayed Neuronal Death Following Acute Focal Brain Ischemia
- Chapter 7.. Gene Expression and Subsequent Molecular Events in Response to Acute Brain Ischemia
- Chapter 8.. Microglial Activation, Cytokine Production, and Local Inflammation in Focal Brain Ischemia
- 8.1.. Dynamics of pro-inflammatory and regulatory cytokines and C-reactive protein concentration in CSF of patients with acute ischemic stroke
- 8.2.. Microvascular-cellular cascade and secondary brain damage
- Chapter 9.. Autoimmune Mechanisms of Trophic Dysfunction and Ischemic Brain Damage
- 9.1.. Nerve growth factor (NGF) and its autoantibody concentration in CSF and serum of patients with ischemic stroke
- 9.2.. Neurospecific protein S100[beta] and its autoantibody concentration in CSF and serum of patients with ischemic stroke
- 9.3.. Myelin basic protein and its autoantibody concentration in CSF and serum of patients with ischemic stroke
- 9.4.. Content of autoantibodies to NGF, S100[beta], and MBP in serum of patients with chronic brain ischemia
- Chapter 10.. Programmed Cell Death. Apoptosis in Focal Brain Ischemia
- Chapter 11.. Reaction of the Stress-Mediating Endocrine System in Response to Acute Brain Ischemia
- Chapter 12.. Molecular Mechanisms of Post-Ischemic Reparation Events
- Part II.. Neuroprotection in Brain Ischemia
- Chapter 13.. Modern Therapeutic Approaches to Acute Focal Brain Ischemia. Basic Strategies for Neuroprotection
- Chapter 14.. Primary Neuroprotection
- 14.1.. Potential-dependent calcium channel antagonists
- 14.2.. Glutamate receptor antagonists
- 14.3.. Inhibitors of synthesis and pre-synaptic release of glutamate
- 14.4.. GABA agonists
- 14.5.. Glycine
- 14.5.1.. Randomized, double-blind, placebo-controlled study of the safety and efficacy of Glycine in carotid ischemic stroke and of its neuroprotective effects
- 14.5.2.. Glycine effects on functional state of brain in patients with carotid ischemic stroke (neurophysiological monitoring)
- Chapter 15.. Secondary Neuroprotection
- 15.1.. Antioxidants
- 15.2.. Anti-intercellular adhesion molecule (anti-ICAM) antibodies
- 15.3.. Pro-inflammatory cytokine inhibitors; anti-inflammatory factors
- 15.4.. Statins and estrogens
- 15.5.. Neurotrophic factors
- 15.6.. Neuropeptides
- 15.6.1.. Semax (ACTH 4-10)
- 15.6.1.1.. Randomized, double-blind, placebo-controlled study of the safety and efficacy of Semax in carotid ischemic stroke and of its neuroprotective effects
- 15.6.1.2.. Influence of Semax on functional state of brain in patients with carotid ischemic stroke
- 15.6.2.. Vasoactive intestinal polypeptide and its derivatives
- 15.6.3.. Cerebrolysin
- 15.6.3.1.. Clinical and neurophysiological study of dose-dependent efficacy of Cerebrolysin in acute ischemic stroke
- 15.7.. Gangliosides
- 15.7.1.. Clinical and neurophysiological study of the effects of Cronassial in acute ischemic stroke
- 15.8.. Prevention of apoptosis
- Chapter 16.. Reparative Therapy
- 16.1.. Piracetam
- 16.1.1.. Clinical and neurophysiological monitoring study of dose-dependent efficacy of piracetam (Nootropil) in acute carotid ischemic stroke
- 16.2.. Citicoline sodium
- 16.3.. Gliatilin
- 16.4.. Carnitine chloride
- Chapter 17.. Strategies and Prospects for Development of Neuro-protective Therapy for Brain Ischemia
- Conclusion
- Index
