DNA topoisomerases in cancer therapy : present and future /

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Bibliographic Details
Imprint:	New York : Kluwer Academic/Plenum Publishers, c2003.
Description:	xii, 202 p. : ill. (some col) ; 24 cm.
Language:	English
Subject:	DNA topoisomerases -- Inhibitors -- Therapeutic use. Cancer -- Chemotherapy. DNA Topoisomerases -- antagonists & inhibitors. Drug Delivery Systems. Neoplasms -- drug therapy. Cancer -- Chemotherapy.
Format:	Print Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/4915548

Hidden Bibliographic Details
Other authors / contributors:	Andoh, Toshiwo.
ISBN:	0306477440 (acid-free paper)
Notes:	Includes bibliographical references and index.

Table of Contents:

Chapter 1. Reflections on an accidental discovery
Chapter 2. Mechanisms of topoisomerase I inhibition by anticancer drugs
Chapter 3. Mechanism of action of topoisomerase II-targeted anticancer drugs
Chapter 4. Degradation of topoisomerase cleavable complexes
Chapter 5. Yeast as a model system in the analysis of DNA topoisomerase I poisons
Chapter 6. Understanding the action of drugs targeting TOP2: Yeast based systems for unraveling drug mechanisms
Chapter 7. Cellular resistance to DNA topoisomerase I-targeting drugs
Chapter 8. Development of new topoisomerase I-targeting compounds as candidate anticancer drugs
Chapter 9. Development of new topoisomerase II-targeting compounds as candidate anticancer drugs
Index

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