Oncogene-directed therapies /
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| Imprint: | Totowa, N.J. : Humana Press, c2003. |
|---|---|
| Description: | xiii, 486 p. : ill. (some col.) ; 26 cm. |
| Language: | English |
| Series: | Cancer drug discovery and development |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/5136177 |
Table of Contents:
- Preface
- Contributors
- Part I.. Basic Concepts in Oncogene Research
- 1. Genetic Basis of Cancer Progression
- 2. The Molecular Basis of Chromosomal Instability in Human Cancer Cells
- 3. Signal Transduction Networks: Ras as a Paradigm
- 4. Oncogenic Receptor Tyrosine Kinases
- 5. Ras-Mediated Deregulation of Gene Expression and Contribution to Oncogenesis
- 6. The Interplay Between Tumor Suppressor Genes and Oncogenes in Tumorigenesis
- 7. Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment
- Part II.. The Functional Impact of Oncogene Expression on Cancer Cells--Therapeutic Implications
- 8. Deregulation of Cell Cycle Progression by Oncogenic Transformation
- 9. Oncogenes as Regulators of Cell Survival: The Role of Oncogenes and Tumor Suppressor Genes in the Induction of Resistance to Anoikis and Hypoxia
- 10. Oncogenes and Tumor Angiogenesis
- 11. Oncogenes as Therapeutic Targets to Prevent Metastasis
- 12. The Impact of Oncogenes on Tumor Maintenance
- 13. Primary and Secondary Events in Oncogene-Driven Tumor Development: Lessons from Transgenic Model Systems
- Part III.. Oncogenes as Targets for Anticancer Therapy In Vivo
- 14. Targeting Oncogenes in Hematopoietic Malignancies
- 15. Clinical Evaluation of Agents Targeting Epidermal Growth Factor Receptor (EGFR) in Cancer
- 16. Inhibition of the HER-2/neu Oncogene: A Translational Research Model for the Development of Future Targeted Therapies
- 17. Farnesyltransferase Inhibitors as Anticancer Agents
- 18. Targeting Oncogenic Signaling Pathways in Human Astrocytomas
- 19. Targeting Oncogenes in Pediatric Malignancies
- 20. Inhibiting Signal Transduction as an Approach to Radiosensitizing Tumor Cells
- 21. Oncogenes as Targets for Cancer Vaccines
- 22. Bcl-2 Antisense Oligonucleotides Therapy for Cancer: Targeting the Mitochondria
- Index
