New bacterial vaccines /
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| Imprint: | Georgetown, Tex. : Landes Bioscience/Eurekah.com ; New York, N.Y. : Kluwer Academic/Plenum, c2003. |
|---|---|
| Description: | 359 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Medical intelligence unit Medical intelligence unit (Unnumbered : 2003) |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/5163845 |
Table of Contents:
- Preface
- 1.. Genomics and Proteomics in Vaccine Design
- A Brief History of Bacterial Vaccines
- Genome Technologies in Vaccine Design
- From Genome to Vaccine Design
- Proteomics in Vaccine Design
- Identification of Antigens Important for Infection
- Future Prospects
- 2.. Universal Proteins As an Alternative Bacterial Vaccine Strategy
- Introduction
- Meningococcal NspA Protein
- Group B Streptococcal Sip Protein
- Pneumococcal BVH Proteins
- Conclusions
- 3.. DNA Vaccines
- Summary
- Elements of the Technology
- Bacterial Vaccines
- Results of Initial Clinical Studies
- Adjuvants and Delivery Vehicles for DNA Vaccines
- Conclusions
- 4.. Live, Attenuated Salmonella Vaccine Vectors
- Introduction
- Live, Attenuated Salmonella Vaccines and Vectors
- Summary
- 5.. Mucosal Immunity
- Introduction
- Distinct Features of the Mucosal Immune System
- Strategies and Routes of Mucosal Immunization
- Selected Approaches to Mucosal Immunization
- Selected Applications of Mucosal Immunization
- The Future for Mucosal Immunization
- 6.. New Technologies for Bacterial Vaccines
- Introduction
- Live Vaccines
- Subunit/Inactivated Vaccines
- DNA
- Formulation of Antigens
- Conclusion
- 7.. Chlamydia trachomatis and Chlamydia pneumoniae Vaccines
- Summary
- Chlamydia Biology and Diseases
- Diagnosis, Treatment and Prevention
- Chlamydia Surface-Exposed Components
- Humoral Immune Response to C. trachomatis
- Mapping of Neutralizing Epitopes on MOMP with Mouse MAbs
- Humoral Immune Response to C. pneumoniae
- Cellular Immunity to C. trachomatis, T-Helper Cell Response
- Cytotoxic T-Cell Response
- Vaccines
- Animal Vaccines and Vaccine Studies
- Vaccine Development
- Conclusion and Perspectives
- 8.. Escherichia coli Vaccines
- Summary
- Introduction
- Clinical Syndromes and Causative Agents
- Vaccine Development Strategies and Experience with Vaccine Candidates
- 9.. A Vaccine for Gonorrhea
- Summary
- Introduction: Gonorrhea Is a Persistent Clinical Problem
- Natural History of Infection
- Surface Structures: Variability in Expression and Antigenicity
- Key Surface Antigens and Their Roles in Pathogenesis
- Stress Proteins
- Lessons Learned about Expression of Gonococcal Antigens from Studies of Infection in Patients and Human Volunteers
- Summary: Pathogenic Strategies Employed by Gonococci during Infection
- The Immune Response
- Animal Models for Studying Vaccines
- Possible Vaccine Candidates
- Questions
- Conclusions
- 10.. Group A Streptococcus Vaccine Research: Historical Synopsis and New Insights
- Group A Streptococcus Distribution, Disease Complexity, Resurgence and Impact
- Disease in the United States and Other Western Countries
- Resurgence of Invasive Disease
- Replacement of GAS M Protein Serotype in Host Populations
- GAS Disease in Developing Countries
- Historical Account of Early GAS Vaccine Efforts
- Protective Immunity by Type-Specific IgG
- Nontype-Specific Protection and Mucosal Immunity
- Additional GAS Vaccine Candidates
- GAS Mediated Autoimmunity in Human Infection
- Newly Described Extracellular Proteins and Antigens of GAS
- Post Genomic Strategies to Study Host-Pathogen Interactions
- Final Comments
- 11.. Academic Pursuits of Vaccines against Group B Streptococcus
- Introduction
- Ecological Niches of GBS
- Epidemiology of GBS Disease
- GBS Targets of Protective Immunity
- Clinical Trials with GBS Vaccines
- Target Populations to Receive GBS Vaccines
- Future of GBS Vaccine Research and Implementation
- Summary
- 12.. Helicobacter pylori Vaccines
- Summary
- Host Immune Program and Disease Pathogenesis
- Raison D'etre for Vaccination
- Surrogate Models of Human Vaccine Efficacy
- Vaccine Effector Pathways and Post-Immunization Gastritis
- H. pylori Vaccine Targeting and Antigen Discovery
- Clinical Trials
- 13.. Lyme Disease Vaccine
- Epidemiology and Ecology
- Bacteriology
- Animal Models
- Pathogenesis
- Immunologic Response to the Spirochete
- Immunization
- Mode of Action
- Human Trials
- Additional Considerations
- Future Vaccines
- Note
- 14.. Moraxella catarrhalis
- Introduction
- Infections Caused by Moraxella catarrhalis
- Epidemiology and Respiratory Tract Colonization
- Immune Response to Infection
- Animal Models
- Vaccine Development
- Future Directions
- 15.. Neisseria meningitidis Vaccines
- Summary
- Introduction
- Immunobiology of Meningococcal Infection
- Strategies for New Vaccines
- Meningococcal Conjugate Vaccines
- Vaccines for Group B
- Genomics As a Vaccine Approach
- Prospects for the Next Five Years
- 16.. A Vaccine for Nontypable Haemophilus influenzae
- Summary
- NTHI Infections and Disease
- Vaccination Strategies for Nontypeable Haemophilus influenzae
- Potential Vaccine Candidates
- Conclusions and Future Directions
- 17.. Vaccines for Pseudomonas aeruginosa
- Secreted Products: Exotoxin A, Alkaline Protease, Elastase
- LPS
- Mucoid Exopolysaccharide (MEP)
- Outer Membrane Proteins (OMPs)
- Flagella
- Pili
- Components of the Type III Secretion System
- Other Aspects of Immunity to P. aeruginosa
- Vaccine Approaches to Elicit Antibody-Mediated and Cell-Mediated Immunity
- Considerations and Conclusions
- 18.. Staphylococcus aureus Vaccine
- Summary
- Introduction
- Capsular Polysaccharide (CP)
- Poly-N-Acetyl Glucosamine (Polysaccharide Intercellular Adhesin)
- Protein Vaccines
- Toxoids
- Conclusion
- 19.. Streptococcus pneumoniae Vaccines
- Abstract
- Introduction
- Polysaccharide Vaccines
- Polysaccharide-Protein Conjugate Vaccines
- Purified Protein Vaccines
- Combination Protein Vaccines
- Mucosal Vaccination Strategies
- DNA Vaccines
- Concluding Remarks
- 20.. New Generation Tuberculosis Vaccines for Targeted Populations
- Mycobacterial Pathogenesis
- Host Response to Infection with Mycobacterium tuberculosis
- The Problem of Persistent Infection with M. tuberculosis
- Lessons Learned from BCG Vaccine
- Improving the BCG Vaccine
- Novel Vaccine Approaches
- Preclinical Testing of New TB Vaccines
- TB Vaccines for Targeted Populations
- Progress Towards the Clinical Investigation of Novel TB Vaccines
- Summary
- 21.. Typhoid Vaccines
- Introduction
- Epidemiology
- Licensed Typhoid Vaccines
- New Typhoid Vaccines
- The Future
- 22.. Vaccines against Vibrio cholerae
- Overview
- Immunobiology
- Strategies for a Cholera Vaccine Based on Epidemiology and Immunobiology
- Efforts to Date
- The Future
- Index
