New bacterial vaccines /

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Bibliographic Details
Imprint:Georgetown, Tex. : Landes Bioscience/Eurekah.com ; New York, N.Y. : Kluwer Academic/Plenum, c2003.
Description:359 p. : ill. ; 24 cm.
Language:English
Series:Medical intelligence unit
Medical intelligence unit (Unnumbered : 2003)
Subject:
Format: Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/5163845
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Other authors / contributors:Ellis, Ronald W.
Brodeur, Bernard R.
ISBN:0306478323
Notes:Includes bibliographical references and index.
Table of Contents:
  • Preface
  • 1.. Genomics and Proteomics in Vaccine Design
  • A Brief History of Bacterial Vaccines
  • Genome Technologies in Vaccine Design
  • From Genome to Vaccine Design
  • Proteomics in Vaccine Design
  • Identification of Antigens Important for Infection
  • Future Prospects
  • 2.. Universal Proteins As an Alternative Bacterial Vaccine Strategy
  • Introduction
  • Meningococcal NspA Protein
  • Group B Streptococcal Sip Protein
  • Pneumococcal BVH Proteins
  • Conclusions
  • 3.. DNA Vaccines
  • Summary
  • Elements of the Technology
  • Bacterial Vaccines
  • Results of Initial Clinical Studies
  • Adjuvants and Delivery Vehicles for DNA Vaccines
  • Conclusions
  • 4.. Live, Attenuated Salmonella Vaccine Vectors
  • Introduction
  • Live, Attenuated Salmonella Vaccines and Vectors
  • Summary
  • 5.. Mucosal Immunity
  • Introduction
  • Distinct Features of the Mucosal Immune System
  • Strategies and Routes of Mucosal Immunization
  • Selected Approaches to Mucosal Immunization
  • Selected Applications of Mucosal Immunization
  • The Future for Mucosal Immunization
  • 6.. New Technologies for Bacterial Vaccines
  • Introduction
  • Live Vaccines
  • Subunit/Inactivated Vaccines
  • DNA
  • Formulation of Antigens
  • Conclusion
  • 7.. Chlamydia trachomatis and Chlamydia pneumoniae Vaccines
  • Summary
  • Chlamydia Biology and Diseases
  • Diagnosis, Treatment and Prevention
  • Chlamydia Surface-Exposed Components
  • Humoral Immune Response to C. trachomatis
  • Mapping of Neutralizing Epitopes on MOMP with Mouse MAbs
  • Humoral Immune Response to C. pneumoniae
  • Cellular Immunity to C. trachomatis, T-Helper Cell Response
  • Cytotoxic T-Cell Response
  • Vaccines
  • Animal Vaccines and Vaccine Studies
  • Vaccine Development
  • Conclusion and Perspectives
  • 8.. Escherichia coli Vaccines
  • Summary
  • Introduction
  • Clinical Syndromes and Causative Agents
  • Vaccine Development Strategies and Experience with Vaccine Candidates
  • 9.. A Vaccine for Gonorrhea
  • Summary
  • Introduction: Gonorrhea Is a Persistent Clinical Problem
  • Natural History of Infection
  • Surface Structures: Variability in Expression and Antigenicity
  • Key Surface Antigens and Their Roles in Pathogenesis
  • Stress Proteins
  • Lessons Learned about Expression of Gonococcal Antigens from Studies of Infection in Patients and Human Volunteers
  • Summary: Pathogenic Strategies Employed by Gonococci during Infection
  • The Immune Response
  • Animal Models for Studying Vaccines
  • Possible Vaccine Candidates
  • Questions
  • Conclusions
  • 10.. Group A Streptococcus Vaccine Research: Historical Synopsis and New Insights
  • Group A Streptococcus Distribution, Disease Complexity, Resurgence and Impact
  • Disease in the United States and Other Western Countries
  • Resurgence of Invasive Disease
  • Replacement of GAS M Protein Serotype in Host Populations
  • GAS Disease in Developing Countries
  • Historical Account of Early GAS Vaccine Efforts
  • Protective Immunity by Type-Specific IgG
  • Nontype-Specific Protection and Mucosal Immunity
  • Additional GAS Vaccine Candidates
  • GAS Mediated Autoimmunity in Human Infection
  • Newly Described Extracellular Proteins and Antigens of GAS
  • Post Genomic Strategies to Study Host-Pathogen Interactions
  • Final Comments
  • 11.. Academic Pursuits of Vaccines against Group B Streptococcus
  • Introduction
  • Ecological Niches of GBS
  • Epidemiology of GBS Disease
  • GBS Targets of Protective Immunity
  • Clinical Trials with GBS Vaccines
  • Target Populations to Receive GBS Vaccines
  • Future of GBS Vaccine Research and Implementation
  • Summary
  • 12.. Helicobacter pylori Vaccines
  • Summary
  • Host Immune Program and Disease Pathogenesis
  • Raison D'etre for Vaccination
  • Surrogate Models of Human Vaccine Efficacy
  • Vaccine Effector Pathways and Post-Immunization Gastritis
  • H. pylori Vaccine Targeting and Antigen Discovery
  • Clinical Trials
  • 13.. Lyme Disease Vaccine
  • Epidemiology and Ecology
  • Bacteriology
  • Animal Models
  • Pathogenesis
  • Immunologic Response to the Spirochete
  • Immunization
  • Mode of Action
  • Human Trials
  • Additional Considerations
  • Future Vaccines
  • Note
  • 14.. Moraxella catarrhalis
  • Introduction
  • Infections Caused by Moraxella catarrhalis
  • Epidemiology and Respiratory Tract Colonization
  • Immune Response to Infection
  • Animal Models
  • Vaccine Development
  • Future Directions
  • 15.. Neisseria meningitidis Vaccines
  • Summary
  • Introduction
  • Immunobiology of Meningococcal Infection
  • Strategies for New Vaccines
  • Meningococcal Conjugate Vaccines
  • Vaccines for Group B
  • Genomics As a Vaccine Approach
  • Prospects for the Next Five Years
  • 16.. A Vaccine for Nontypable Haemophilus influenzae
  • Summary
  • NTHI Infections and Disease
  • Vaccination Strategies for Nontypeable Haemophilus influenzae
  • Potential Vaccine Candidates
  • Conclusions and Future Directions
  • 17.. Vaccines for Pseudomonas aeruginosa
  • Secreted Products: Exotoxin A, Alkaline Protease, Elastase
  • LPS
  • Mucoid Exopolysaccharide (MEP)
  • Outer Membrane Proteins (OMPs)
  • Flagella
  • Pili
  • Components of the Type III Secretion System
  • Other Aspects of Immunity to P. aeruginosa
  • Vaccine Approaches to Elicit Antibody-Mediated and Cell-Mediated Immunity
  • Considerations and Conclusions
  • 18.. Staphylococcus aureus Vaccine
  • Summary
  • Introduction
  • Capsular Polysaccharide (CP)
  • Poly-N-Acetyl Glucosamine (Polysaccharide Intercellular Adhesin)
  • Protein Vaccines
  • Toxoids
  • Conclusion
  • 19.. Streptococcus pneumoniae Vaccines
  • Abstract
  • Introduction
  • Polysaccharide Vaccines
  • Polysaccharide-Protein Conjugate Vaccines
  • Purified Protein Vaccines
  • Combination Protein Vaccines
  • Mucosal Vaccination Strategies
  • DNA Vaccines
  • Concluding Remarks
  • 20.. New Generation Tuberculosis Vaccines for Targeted Populations
  • Mycobacterial Pathogenesis
  • Host Response to Infection with Mycobacterium tuberculosis
  • The Problem of Persistent Infection with M. tuberculosis
  • Lessons Learned from BCG Vaccine
  • Improving the BCG Vaccine
  • Novel Vaccine Approaches
  • Preclinical Testing of New TB Vaccines
  • TB Vaccines for Targeted Populations
  • Progress Towards the Clinical Investigation of Novel TB Vaccines
  • Summary
  • 21.. Typhoid Vaccines
  • Introduction
  • Epidemiology
  • Licensed Typhoid Vaccines
  • New Typhoid Vaccines
  • The Future
  • 22.. Vaccines against Vibrio cholerae
  • Overview
  • Immunobiology
  • Strategies for a Cholera Vaccine Based on Epidemiology and Immunobiology
  • Efforts to Date
  • The Future
  • Index