Immunology, infection, and immunity /

Immunology, infection, and immunity /

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Bibliographic Details
Imprint:Washington, D.C. : ASM Press, c2004.
Description:xxiii, 718 p. : col. ill. ; 29 cm.
Language:English
Subject:
Immunology.
Infection.
Immune System.
Immunity, Cellular.
Immune System Diseases.
Infection.
Immunology.
Infection.
Format: Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/5172703
Hidden Bibliographic Details
Other authors / contributors:Pier, Gerald Bryan.
Lyczak, Jeffrey B.
Wetzler, Lee M.
ISBN:1555812465 (hardcover)
Notes:Includes bibliographical references and index.
Table of Contents:
  • Contributors
  • Preface
  • About the Editors
  • Section I. Function and Composition of the Immune System
  • Chapter 1. Overview of Immunity
  • Overview of Immunology
  • Innate Immunity
  • Mechanisms of Adaptive Immunity
  • Interactions between Acquired and Innate Immunity
  • Summary
  • Suggested Reading
  • Chapter 2. Innate Immunity
  • Physical and Physiologic Barriers
  • Enzymatic and Protein Effectors
  • Cellular Effectors of Innate Immunity
  • Innate Responses to Viral Infection
  • Inflammation: Orchestrating the Innate Effectors
  • Cross-Talk between the Innate and Acquired Arms of Immunity
  • Summary
  • Suggested Reading
  • Chapter 3. Cells of the Immune System
  • Hematopoiesis and Generation of Cells of the Immune System
  • Identification of Cells via Surface Markers
  • Morphology and Function of Myeloid Cells
  • Morphology and Function of Lymphoid Cells
  • Major Populations and Subpopulations of Lymphocytes
  • Summary
  • Suggested Reading
  • Chapter 4. Organs and Tissues of the Immune System
  • Generative Lymphoid Organs
  • The Anatomy of Immune Responses
  • Peripheral Lymphoid Organs
  • MALT
  • Cutaneous Immunity
  • Summary
  • Suggested Reading
  • Chapter 5. Complement
  • Complement Proteins
  • Activation of Complement
  • Functions of Complement
  • Regulation of Complement Activation
  • Synthesis of Complement Proteins
  • Disorders Associated with Defects in Synthesis of Complement Proteins
  • Summary
  • Suggested Reading
  • Section II. Antibodies
  • Chapter 6. Antibodies
  • Chemical Structure of Antibodies
  • Classification of Antibodies
  • The Immunoglobulin Superfamily
  • Suggested Reading
  • Chapter 7. Molecular Genetics of Antibody Diversity
  • Observations and Theories Predating Molecular Genetics of Immunoglobulin Genes
  • Organization of the Immunoglobulin Genes
  • The Mechanism of Variable-Region Gene Assembly
  • Generation of Antibody Diversity
  • Productive and Nonproductive Rearrangements: Allelic Exclusion
  • B-Cell Differentiation
  • Regulation of Immunoglobulin Expression
  • An AID in the Generation of Immunoglobulin Diversity
  • Summary
  • Suggested Reading
  • Chapter 8. Antigens, Antigenicity, and Immunogenicity
  • General Properties of Antigens
  • Activation of T Cells and B Cells by Antigen
  • Antigenicity and Immunogenicity
  • Adjuvants
  • Important Antigens from Infectious Agents
  • Superantigens
  • Mitogens
  • Summary
  • Suggested Reading
  • Chapter 9. Antibody-Antigen Interactions and Measurements of Immunologic Reactions
  • The Concept of Specificity
  • Deviations from Absolute Specificity
  • The Physical Nature of the Antibody-Antigen Interaction
  • The Law of Mass Action and Its Application to Antigen-Antibody Binding
  • Types of Assays To Measure Antigen-Antibody Interactions
  • Use of Antibodies To Differentiate Tissues and Cells
  • Measurements of Immunity to Infection
  • Measurements of Cell-Mediated Immunity
  • Summary
  • Suggested Reading
  • Chapter 10. B-Lymphocyte Activation and Antibody Production
  • Interaction of Antigen and B Lymphocyte: the BCR
  • Regulation of BCR Signal Transduction
  • Germinal Centers and B-Cell Maturation
  • Interaction of B Cells with FDCs
  • Antibody Production by B Lymphocytes
  • TI Antibody Response
  • TD Antibody Response
  • B-Lymphocyte Interaction with T Lymphocytes
  • Effect of Cytokines on B-Cell Activation and Antibody Production
  • Isotype Switching
  • Apoptosis: the Flip Side of B-Cell Activation
  • Summary
  • Suggested Reading
  • Section III. Cellular Immunity
  • Chapter 11. The Major Histocompatibility Complex
  • Discovery of the MHC Gene Complex
  • General Arrangement of the MHC Gene Complex
  • Basic Nomenclature of MHC Genes and Proteins
  • Use of Inbred Mouse Strains in Experimental Immunology
  • Structure of MHC Class I and Class II Proteins
  • Peptide Binding by MHC Class I and Class II Proteins
  • Serologic and Sequence-Based Identification of MHC Proteins and Relationship to MHC Polymorphism
  • MHC Proteins with Ancillary Roles in Antigen Presentation
  • MHC Class III: MHC Proteins with No Role in Antigen Presentation
  • Roles of Some Nonclassical MHC Gene Products in Activation of T Cells in Response to Novel Stimuli
  • MHC-Like Antigen-Presenting Molecules Encoded by Genes Located outside the MHC and Roles in Presentation of Unusual Antigens
  • Summary
  • Suggested Reading
  • Chapter 12. Antigen Processing and Presentation
  • APCs
  • Antigen-Processing Pathways
  • Antigen Presentation by MHC Class I
  • Antigen Presentation by MHC Class II
  • Presentation of Nonclassical, Nonprotein Antigens to T Cells
  • Summary
  • Suggested Reading
  • Chapter 13. The T-Cell Receptor
  • Isolation and Characterization of the TCR
  • Structure of the TCR
  • Organization of TCR Genes
  • Generation of Diversity in the TCR
  • Production of a Functional Receptor
  • Summary
  • Suggested Reading
  • Chapter 14. T-Cell Maturation and Activation
  • T-Cell Maturation and Development in the Thymus
  • Tolerance
  • T-Cell Activation and Antigen Recognition
  • Summary
  • Suggested Reading
  • Chapter 15. Cellular Communication
  • Interaction of Cells of the Immune System
  • Soluble Mediators of Communication: Cytokines and Chemokines
  • Cytokine Families
  • Role of Cytokines in Other Diseases
  • Summary
  • Suggested Reading
  • Section IV. Immunologic Effector Systems and Immunity to Infection
  • Chapter 16. Cell-Mediated Immunity
  • Fundamental Aspects of Cell-Mediated Immunity
  • Initiating Cell-Mediated Immunity
  • DTH Reactions
  • Cell-Mediated Cytotoxicity
  • CTLs
  • ADCC
  • Summary
  • Suggested Reading
  • Chapter 17. Mucosal Immunity
  • GALT
  • Airway Immunity: BALT
  • Urogenital Tract Immunity
  • Damage to Mucosal Sites by the Immune Response
  • Summary
  • Suggested Reading
  • Chapter 18. Immunity to Bacterial Infections
  • Bacteria and Disease
  • Immune System Function and Resistance to Bacterial Infections
  • The Study of How Bacteria Cause Disease: Bacterial Pathogenesis
  • Initial Stage of Bacterial Infection: Colonization of Host Surfaces
  • Tissue Invasion and Disease
  • Bacterial Virulence Factors: How They Thwart Host Immunity
  • Bioterrorism and Bacterial Pathogens
  • Antigenic Targets Involved in Protective Immunity
  • Summary
  • Suggested Reading
  • Chapter 19. Immunity to Viruses
  • Viruses and Disease
  • Viruses and Acquired Immunity
  • Structural Properties of the Virus
  • Replication of the Virus
  • Evasion of Host Antiviral Immune Defenses
  • Summary
  • Suggested Reading
  • Chapter 20. Immunity to Parasitic and Fungal Infections
  • Protozoal Infections
  • Helminthic Infections
  • Immune Responses in Parasitic Infections
  • Immune Effectors in Parasitic Infections
  • Immune Evasion by Parasites
  • Immunology of Fungal Infections
  • Summary
  • Suggested Reading
  • Chapter 21. Vaccines and Vaccination
  • Early and Defining Issues in Vaccine Development
  • Basic Concepts in Vaccination
  • Immune Recognition of Pathogens
  • Vaccine Components and Vaccination Strategies
  • Bacterial Vaccines
  • Viral Vaccines
  • Vaccines for Fungal Infections
  • Vaccines for Parasitic Diseases
  • Passive Immunization
  • Summary
  • Suggested Reading
  • Section V. Immune System Dysfunction: Deficiencies
  • Chapter 22. Immunology and AIDS
  • Etiology and Epidemiology of AIDS
  • The Viral Genome
  • Pathogenesis
  • Immune Defects Due to HIV-1 Infection
  • Immune Responses to HIV-1 Infection
  • Evasion of Immune Responses by HIV-1
  • Pharmacologic Therapy for HIV-1 Infection
  • Potential Vaccines and Immunotherapies for HIV-1 Infection
  • Summary
  • Suggested Reading
  • Chapter 23. Clinical and Genetic Perspectives in Primary Immunodeficiency Disorders
  • Basic Defects Leading to Immune Dysfunction
  • Clinical Manifestations of Immunodeficiency
  • Respiratory Tract Infection
  • Skin Manifestations of Immune Deficiency
  • Oral Manifestations of Immune Deficiency
  • Viral Illnesses or Vaccine Complications of Unusual Severity
  • Summary
  • Suggested Reading
  • Chapter 24. Cancer and the Immune System
  • Cancer Is a Disease of Genes
  • The Immune Response to Cancer
  • Mechanisms of Antitumor Immunity
  • Immune Cell Types Important in Antitumor Immunity
  • Tumor Surveillance Theory
  • Tumor Immunotherapy
  • Summary
  • Suggested Reading
  • Section VI. Immune System Dysfunction: Overactivity
  • Chapter 25. Hypersensitivity
  • Historical Understanding of the Concept of Hypersensitivity
  • Subtypes of Allergic Responsiveness
  • Summary
  • Suggested Reading
  • Chapter 26. Autoimmunity and Disease
  • Autoimmunity and Autoimmune Disease
  • Targets of Autoimmune Diseases
  • Pathogenesis of Autoimmune Diseases
  • Animal Models of Autoimmune Diseases
  • Etiology of Autoimmunity
  • Therapy for Autoimmune Diseases
  • Summary
  • Suggested Reading
  • Chapter 27. Transplantation Immunology
  • The Role of Major Histocompatibility Antigens versus Minor Histocompatibility Antigens in Transplantation
  • Tissue Typing
  • Initiation of a Graft Rejection Response
  • T-Cell Activation
  • Effector Mechanisms of Allograft Rejection
  • Chemokines
  • Graft-versus-Host Disease
  • Tolerance
  • Immunosuppression
  • Classes of Immunosuppressive Drugs
  • Summary
  • Suggested Reading
  • Appendix A. CD Antigens
  • Appendix B. Antigen Names with CD Designation Equivalents
  • Appendix C. Cytokines, Chemokines, and Their Receptors
  • Appendix D. Cell Types and Immune-Related Functions
  • Appendix E. Historical Timeline of Immunology
  • Appendix F. Time Course of a Typical Immune Response
  • Appendix G. Comparison of Relative Sizes of Cells, Structures, and Molecules That Are Relevant to Infection and Immunity
  • Index
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