One hundred years of chromosome research and what remains to be learned /
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| Author / Creator: | Lima-de-Faria, A. |
|---|---|
| Imprint: | Dordrecht ; Boston : Kluwer Academic Publishers, 2003. |
| Description: | vii, 219 p. : ill. ; 31 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/5176264 |
Table of Contents:
- Introduction
- Part I. Nine Periods of Chromosome Research: 1795 to 2010
- First Period 1795-1850 The precursors: Better microscopes allowed reaching the cell level
- Second Period 1850-1900 The pioneers: The discovery of the chromosome was a by-product of microbiology
- Third Period 1900-1930 The era of abstract genetics: Order in embryonic development led to the finding of order in inheritance
- Fourth Period 1930-1950 The impact of physics and chemistry on genetics: World War II encouraged the development of microbial genetics
- Fifth Period 1950-1970 Radioisotopes and electron microscopy became a most fruitful combination: Molecular biology received its main impulse from disciplines outside genetics
- Sixth Period 1970-1980 The mechanisms of cancer and of development were sought at the DNA level: Biotechnology emerged as a new field as genetics created its own weapons
- Seventh Period 1980-1990 Neurobiology reached the molecular level: Artificial chromosomes and gene therapy became a reality
- Eighth Period 1990-2001 The genome of humans and of other organisms was sequenced: The age of multilaboratory collaboration was established
- Ninth Period 2001-2010 The post-genome era: The task that lies ahead
- Part II. The Technology that Allowed the Study of the Chromosome: 1900 to 2001
- From staining methods to DNA sequencing
- Part III. In Search of the Eukaryotic Chromosome
- Main stages in the discovery of the cell's structure and function
- The nucleus versus the cytoplasm. Which was most important?
- The description of cell division: An impressive transformation was accompanied by directed cellular movements
- Meiosis was another unexpected property: The cell could reduce its chromosome number
- The maintenance of identity of the chromosome during interphase was accompanied by constancy and variability of pattern in different tissues
- Part IV. The Three Unique Regions of the Eukaryotic Chromosome
- The centromere: A Pandora's box of unearthed properties
- The telomere: Not just a terminus station
- The nucleolus organizer: Nothing in the cell is comparable to it
- Part V. No Chromosome can Function Outside a Cell
- Cytoskeleton: A disgusting artifact became an important cell edifice
- Nuclear envelope: The nucleus disclosed its outer structure
- Centriole: An enigmatic cell invention
- Endoplasmic reticulum and Golgi apparatus: The building of membranes permitted molecular reactions to occur in defined sequences
- Cell membrane and cell wall: The cell became an individualized entity
- Part VI. Specific Types of Chromosomes
- Chromosomes of viruses: An early or a late form of chromosome?
- Chromosomes of bacteria: Nearly naked DNA could become independent
- Chromosomes of mitochondria: Intruders invaded the cell
- Chromosomes of chloroplasts: Additional genomes entered the cell
- Part VII. The Antithetical Properties of the Chromosome
- Physico-chemical processes are antithetical
- The Chromosome's Rigidity
- Maintenance of organization: The protozoan versus the human chromosome
- Maintenance of the chromosome phenotype
- Maintenance of gene order
- Maintenance of function
- The periodicity of chromosome transformations
- The Chromosome's Plasticity
- Structural change
- Change of pattern
- Change in size
- Change in number
- Change in function
- Part VIII. Chromosome Models and what they do not Tell US
- The models
- What the models do not tell us
- Part IX. Epilogue
- Where did the chromosome come from?
- Where is the chromosome going?
- Bibliography: A list of selected books that have dealt with the chromosome during the period 1870-2001
- References: Cited works between 1990 and 2001
- Sources of Illustrations
- Subject index
- Author inded
