Oxygen/nitrogen radicals : lung injury and disease /
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| Imprint: | New York : Marcel Dekker, Inc., c2004. |
|---|---|
| Description: | xvii, 529 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Lung biology in health and disease ; v. 187 |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/5202190 |
Table of Contents:
- Introduction
- Preface
- Contributors
- 1.. Reactive Oxygen/Nitrogen Species: Generation and Reactions in the Lung
- I.. Introduction
- II.. Reactive Oxygen Species
- III.. Reactive Nitrogen Species
- IV.. Further Reactions of ROS and RNS with Biological Molecules
- V.. Conclusions
- References
- 2.. Oxidative Stress/Antioxidant Status in Health and Disease
- I.. Introduction
- II.. Antioxidants in Normal Healthy Lung
- III.. Antioxidants in Lung Diseases
- IV.. Oxidative Stress and Antioxidant Genes
- V.. Pharmacological Modulation and Clinical Benefits
- VI.. Conclusions
- References
- 3.. Reactive Oxygen Species in the Activation and Regulation of Intracellular Signaling Events
- I.. Introduction
- II.. Sources of ROS
- III.. ROS and Signal Transduction
- IV.. Is p53 Regulated by or a Regulator for ROS?
- V.. ROS Regulation of Nuclear Factor of Activated T Cells
- VI.. Summary
- References
- 4.. Mediators of Lung Inflammation: Role of Reactive Oxygen and Nitrogen Species
- I.. Introduction
- II.. Immune Complex-Induced Injury as a Model for Oxidant-Mediated Lung Inflammation
- III.. Superoxide and Oxygen Radicals
- IV.. Nitric Oxide
- V.. Proteases
- VI.. Endogenous Mediators: Cytokines, Transcription Factors, Chemokines, and Adhesion Molecules
- VII.. Role of C5a in Acute Lung Inflammation
- VIII.. Clinical Relevance
- IX.. Conclusions
- References
- 5.. Pulmonary Complications of Chronic Granulomatous Disease
- I.. Introduction
- II.. Molecular Basis of CGD and Defects in Oxidative Metabolism
- References
- 6.. Genotoxic and Carcinogenic Mechanisms of Mineral Fibers: Role of Reactive Oxygen Species
- I.. Introduction
- II.. Asbestos as a Gene and Chromosomal Mutagen
- III.. Fiber-Cell Interaction in Mediating Genotoxic Response
- IV.. Detection of Oxy Radicals Produced by Asbestos Fibers
- V.. Effect of Depleted Intracellular Glutathione Level on Fiber Mutagenesis
- VI.. Induction of Oxidative DNA Damage by Asbestos Fibers
- VII.. Types of Mutations Induced by Asbestos Are Similar to Those of Hydrogen Peroxide
- VIII.. Transformation Studies with Human Epithelial Cells
- IX.. Gene Expression Profile in Asbestos-Induced Tumor Cells
- X.. Ectopic Expression of the [beta]ig-h3 Gene Suppressive Tumorigenicity
- XI.. Conclusion
- References
- 7.. Influence of Mineral Dust Surface Characteristics and Generation of Reactive Species
- I.. Introduction
- II.. Asbestos
- III.. Phyllosilicates and Coal
- IV.. Conclusions
- References
- 8.. Oxygen/Nitrogen Radicals and Silica-Induced Diseases
- I.. Introduction
- II.. Generation of Reactive Oxygen Species from Crystalline Silica
- III.. Generation of Reactive Oxygen Species from Lung Cells Exposed to Silica
- IV.. Nitric Oxide Production by Lung Cells
- V.. Summary
- References
- 9.. Asbestosis and Asbestos-Related Cancers: Role of Reactive Oxygen and Nitrogen Species
- I.. Introduction
- II.. Diseases Caused by Asbestos
- III.. Generation of ROS/RNS by Asbestos
- IV.. Role of ROS/RNS in Asbestos-Associated Cellular Effects
- V.. Asbestos-Induced RNS Generation and Pulmonary Toxicity
- VI.. Summary
- References
- 10.. Interactions of Exogenous or Evoked Reactive Oxygen Species and Inhaled Particles in the Lung
- I.. Introduction
- II.. Adhesion of Particles to Epithelial Cells
- III.. Particle Uptake and Retention by Epithelial Cells
- IV.. Exogenous or Evoked ROS and Pathological Reactions to Particles
- V.. Conclusions
- References
- 11.. Smoking-Induced Inflammation, Injury, and Disease: Molecular Mechanisms
- I.. Introduction
- II.. Cigarette Smoke and Oxidative Stress
- III.. ROS-Mediated Lipid Peroxidation Products and Their Role in Biochemical Processes
- IV.. Involvement of Cigarette Smoke-Mediated Lipid Peroxidation Products in Cell Signaling and Gene Transcription
- V.. Role of ROS and Cigarette Smoke-Induced Oxidative Stress in Chromatin Modeling: Role for Histone Acetylation/Deacetylation and DNA Methylation
- VI.. Conclusions
- References
- 12.. Respiratory Health Effects of Ambient Air Pollution Particles: Role of Reactive Species
- I.. Oxidative Stress in the Lungs
- II.. PM[subscript 10] Measurement and Adverse Health Effects
- III.. Inflammation and Oxidative Stress as Factors in the Adverse Effects of PM[subscript 10]
- IV.. Oxidative Activity of PM
- V.. Induction of Oxidative Stress-Responsive Signaling Pathways
- VI.. Conclusions
- References
- 13.. Ozone-Induced Lung Injury: Role of Macrophages and Inflammatory Mediators
- I.. Introduction
- II.. Ozone-Induced Lung Injury and Inflammation
- III.. Cell Adhesion Molecules and Ozone Toxicity
- IV.. Inflammatory Mediators and Ozone Toxicity
- V.. Mechanisms Regulating the Production of Inflammatory Mediators in the Lung Following Ozone Exposure
- VI.. Conclusions
- References
- 14.. Oxidative Stress in Chronic Obstructive Pulmonary Disease
- I.. Introduction
- II.. Oxidants in Cigarette Smoke
- III.. Cell-Derived Oxidants
- IV.. Oxidative Stress and the Pathogenesis of COPD
- V.. Local Oxidative Stress in the Lungs
- VI.. Systemic Oxidative Stress
- VII.. Surrogate Markers of Oxidative Stress in the Lungs
- VIII.. Oxidative Stress and Susceptibility to COPD
- IX.. Therapy to Target Oxidative Stress
- X.. Future Perspectives
- References
- 15.. Chronic Obstructive Pulmonary Disease: Mechanisms of Disease Development and Prevention Strategies with Antioxidants
- I.. Introduction
- II.. Prevalence
- III.. Risk Factors
- IV.. Pathogenesis
- V.. Mechanisms of Disease Development
- VI.. Prevention Strategies with Antioxidants
- VII.. Conclusions
- References
- 16.. Acute Respiratory Distress Syndrome and Oxidative Stress: Mechanisms of Disease Development and Opportunities for Antioxidant Prevention
- I.. Introduction
- II.. Pathology and Pathogenesis
- III.. Important Factors in the Pathogenesis of ARDS
- IV.. Antioxidant Therapy
- V.. Conclusions
- References
- 17.. Asthma and Oxidative Stress
- I.. Introduction
- II.. Synthesis and Metabolism
- III.. Effects on Airway Function
- IV.. Role in Asthma
- V.. Concluding Remarks
- References
- 18.. Cellular Responses of the Lungs to Hyperoxia
- I.. Introduction
- II.. Background
- III.. Pulmonary Distribution of Oxygen
- IV.. Stages in the Progression of Acute Oxygen Toxicity
- V.. Responses to Sublethal Hyperoxia Exposure
- VI.. Pulmonary Antioxidant Enzymes and Their Distribution
- VII.. Role of Airways and Other Nonparenchymal Tissues in Hyperoxia
- VIII.. Necrotic Versus Apoptotic Cell Death
- IX.. Neonatal Hyperoxia
- X.. Experimental Manipulations of Pulmonary Defenses Against Hyperoxia
- References
- 19.. Vanadium- and Chromium-Induced Cell Signal Transduction
- I.. Introduction
- II.. Vanadium
- III.. Chromium
- IV.. Conclusions
- References
- 20.. Molecular Mechanisms of Oxidant-Induced Pulmonary Carcinogenesis
- I.. Introduction
- II.. Sources of Oxidants and Oxidative Stress
- III.. Mechanisms of Oxidant-Induced Carcinogenesis
- IV.. Conclusions
- References
- Index
