Catalytic antibodies /
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| Imprint: | Weinheim : Wiley-VCH ; [Chichester : John Wiley], 2005. |
|---|---|
| Description: | xxx, 586 p. : ill. (some col.) ; 24 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/5551963 |
Table of Contents:
- 1. Immunological Evolution of Catalysis
- 1.1. Introduction
- 1.2. Parallels between Antibody and Enzyme Evolution
- 1.3. Evolution of Catalytic Antibodies
- 1.4. Ferrochelatase Antibody 7G12 - Evolution of the Strain Mechanism
- 1.5. Esterase Antibody 48G7 - Effect of Distant Mutations on Catalysis
- 1.6. Sulfur Oxidase Antibody 28B4 - Incremental Changes in Evolution
- 1.7. Oxy-Cope Antibody AZ28 - Evolution of Conformational Diversity in Catalysis
- 1.8. Diels-Alderase Antibody 39A11 - Evolution of a Polyspecific Antibody combining Site
- 1.9. Conclusions
- References
- 2 Critical Analysis of Antibody Catalysis.
- 2.1. Introduction
- 2.2. Exploiting Antibodies as Catalysts
- 2.3. Catalytic Efficiency
- 2.4. Hapten Design
- 2.5. Representative Catalytic Antibodies
- 2.6. Perspectives
- 2.7. Conclusions
- References
- 3 Theoretical Studies of Antibody Catalysis.
- 3.1. Introduction
- 3.2. Questions Subject to Theoretical Elucidation
- 3.3. Hydrolytic Antibodies
- 3.4. Cationic Cyclizations
- 3.5. Antibody-Catalyzed Diels-Alder and retro-Diels-Alder Reactions
- 3.6. Other Antibody-Catalyzed Pericyclic Reactions
- 3.7. Antibody-Catalyzed Carboxybenzisoxazole Decarboxylation
- 3.8. Summary
- References
- 4. The Enterprise of Catalytic Antibodies: A Historical Perspective
- 4.1. Introduction
- 4.2. Methods
- 4.3. Results
- 4.4. Conclusions
- References
- 5. Catalytic Antibodies in Natural Products Synthesis
- 5.1. Introduction
- 5.2. Total Synthesis of a-Multistriatin via Antibody-Catalyzed Asymmetric Protonolysis of an Enol Ether
- 5.3. Total Synthesis of Epothilones Using Aldolase Antibodies
- 5.4. Total Synthesis of Brevicomins Using Aldolase Antibody 38C2
- 5.5. Synthesis of 1-Deoxy-L-Xylose Using 38C2 Antibody
- 5.6. Synthesis of (+)-Frontalin and Mevalonolactone via Resolution of Tertiary Aldols with 38C2
- 5.7. Wieland-Miescher Ketone via 38C2-Catalyzed Robinson Annulation
- 5.8. Formation of Steroid A and B Rings via Cationic Cyclization
- 5.9. Synthesis of Naproxen via Antibody-Catalyzed Ester Hydrolysis
- 5.10. Conclusions
- References
- 6 Structure and Function of Catalytic Antibodies.
- 6.1. Introduction
- 6.2. Electrostatic Complementarity
- 6.3. Shape Complementarity and Approximation
- 6.4. Shape Complementarity and Control of the Reaction Coordinate
- 6.5. Shape Complementarity and Substrate Strain
- 6.6. Reactive Amino Acids and the Possibility of Covalent Catalysis
- 6.7. New Challenges
- References
- 7. Antibody Catalysis of Disfavored Chemical Reactions
- 7.1. Introduction
- 7.2. Formal Violation of Baldwin's Rules for Ring Closure: the 6-endo-tet Ring Closure
- 7.3. Cationic Cyclization
- 7.4. exo-Diels-Alder Reactions
- 7.5. Miscellaneous Disfavored Processes
- 7.6. Summary
- References
- 8. Screening Methods for Catalytic Antibodies
- 8.1. Introduction
- 8.2. Theoretical Consideration: What to look for during screening
- 8.3. A Practical Perspective: Screening in the Published Literature
- 8.4. High-Throughput Screening Methods
- 8.5. Examples with Fluorogenic Substrates and Antibodies from Hybridoma
- 8.6. Conclusion
- References
