Cell signalling /

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Bibliographic Details
Author / Creator:	Hancock, John T.
Edition:	2nd ed.
Imprint:	Oxford ; New York : Oxford University Press, 2005.
Description:	xix, 296 p. : ill. ; 25 cm.
Language:	English
Subject:	Cell interaction. Cellular signal transduction. Cell interaction. Cellular signal transduction.
Format:	Print Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/5672346

Hidden Bibliographic Details
ISBN:	0199264678 (pbk.)
Notes:	Previous ed.: Harlow: Longman, 1997. Includes bibliographical references and index.

Table of Contents:

Preface
Abbreviations
1. Aspects of cellular signalling
1.1. Introduction
1.2. The main principles of cell signalling
1.3. What makes a good signal?
1.4. Different ways in which cells signal to each other
Electrical and synaptic
Endocrine
Paracrine
Autocrine
Direct cell-cell signalling
Receptor-ligand signalling
Gap junctions and plasmodesmata
1.5. Amplification and physical architectures
1.6. Coordination of signalling
1.7. Domains and modules
14-3-3 proteins
1.8. Oncogenes
1.9. A brief history
The early days
A growing volume of work in the field
Phosphorylation research
Work on G proteins
Recent events and the future
1.10. The techniques in the study of cell signalling components
Labelling techniques
The use of probes
Pharmacological tools
Structure and protein interactions
Molecular genetic techniques
Microarrays and proteomics
Computer networks
1.11. Summary
1.12. Further Reading
1.13. Useful Web Pages
2. Extracellular signals: hormones, cytokines, and growth factors
2.1. Introduction
2.2. Hormones
Small water-soluble molecules
Peptide hormones
Lipophilic molecules which are detected by cell-surface receptors
Lipophilic molecules which are detected by intracellular receptors
2.3. Plant hormones
Auxin
Cytokinins
Gibberellins
Abscisic acid
Ethylene
Other plant hormones
2.4. Cytokines
Interleukins
Interferons
Tumour necrosis factors
Other cytokines, chemokines, and receptors
2.5. Growth factors
Platelet-derived growth factors
Epidermal growth factor
Fibroblast growth factor
2.6. Neurotransmitters
2.7. ATP as an extracellular signal
2.8. Pheromones
2.9. Summary
2.10. Further Reading
2.11. Useful Web Pages
3. Detection of extracellular signals: the role of receptors
3.1. Introduction
3.2. Types of receptor
G protein-linked receptors
Ion channel-linked receptors
Receptors containing intrinsic enzymatic activity
Receptors linked to separate tyrosine kinases
Intracellular receptors of extracellular signals
3.3. Ligand binding to their receptors
3.4. Receptor sensitivity and receptor density
3.5. Summary
3.6. Further Reading
3.7. Useful Web Pages
4. Protein phosphorylation, kinases, and phosphatases
4.1. Introduction
4.2. Serine/threonine kinases
cAMP-dependent protein kinase
cGMP-dependent protein kinase
Protein kinase C
Ca[superscript 2+]/calmodulin-dependent protein kinases
G protein-coupled receptor kinases
Protein kinase B
AMP-activated protein kinase
Haem-regulated protein kinase
Plant-specific serine/threonine kinases
4.3. Tyrosine kinases
Receptor tyrosine kinases
Cytosolic tyrosine kinases
4.4. Mitogen-activated protein kinases
4.5. Histidine phosphorylation
4.6. Phosphatases
Serine/threonine phosphatases
Tyrosine phosphatases
4.7. Other covalent modifications
4.8. Summary
4.9. Further Reading
5. Cyclic nucleotides, cyclases, and G proteins
5.1. Introduction
5.2. cAMP
5.3. Adenylyl cyclase
5.4. Adenylyl cyclase control and the role of G proteins
The heterotrimeric G protein family
The roles of the [beta]/[gamma] complex
Other roles of the heterotrimeric G proteins
5.5. Guanylyl cyclase
Soluble guanylyl cyclase
Membrane-bound guanylyl cyclase
5.6. Phosphodiesterases
5.7. The GTPase superfamily: functions of monomeric G proteins
Other Ras-related proteins
5.8. Summary
5.9. Further Reading
6. Inositol phosphate metabolism and roles of membrane lipids
6.1. Introduction
6.2. Events at the membrane
6.3. The breakdown of the inositol phosphate lipids
Phospholipase C
6.4. Inositol 1,4,5-trisphosphate and its fate
6.5. The role of diacylglycerol
6.6. Inositol phosphate metabolism at the nucleus
6.7. Other lipids involved in signalling
Phosphatidylcholine and arachidonic acid metabolism
Phospholipase D
Sphingolipid pathways
6.8. Related lipid-derived signalling molecules
6.9. Summary
6.10. Further Reading
7. Intracellular calcium: its control and role as an intracellular signal
7.1. Introduction
7.2. Calmodulin
7.3. The plasma membrane and its role in calcium concentration maintenance
7.4. Intracellular stores
Endoplasmic reticulum stores
Mitochondrial calcium metabolism
7.5. Nerve cells
7.6. Gradients, waves, and oscillations
7.7. Sphingosine 1-phosphate
7.8. Cyclic ADP-ribose
7.9. Nicotinate adenine-dinucleotide phosphate
7.10. Fluorescence detection and confocal microscopy
7.11. Summary
7.12. Further Reading
8. Reactive oxygen species, reactive nitrogen species, and redox signalling
8.1. Introduction
8.2. Nitric oxide
Other enzymatic sources of NO
8.3. Reactive oxygen species: superoxide and hydrogen peroxide
Evidence for superoxide and hydrogen peroxide acting as a signal
The NADPH oxidase complex
Chronic granulomatous disease, non-phagocytes, and plants
Other sources of superoxide
8.4. Redox signalling and molecular mechanisms of hydrogen peroxide signalling
8.5. Measuring ROS and RNS
8.6. Carbon monoxide
8.7. Summary
8.8. Further Reading
9. Insulin and the signal transduction cascades it invokes
9.1. The insulin signalling system
9.2. Summary
9.3. Further Reading
10. Perception of the environment
10.1. Introduction
10.2. Photodetection in the eye
10.3. Other environment-perception systems
10.4. Summary
10.5. Further Reading
11. Life, death, and apoptosis
11.1. Introduction
11.2. An overview of apoptosis
11.3. Caspases
11.4. The intrinsic pathway
11.5. The extrinsic pathway
Death receptors
Signalling from death receptors
11.6. Summary
11.7. Further Reading
12. Importance, complexity, and the future
12.1. Introduction
12.2. Specificity, subtlety, and crosstalk
12.3. Longer-term effects
12.4. The future
12.5. Further Reading
Index

Cell signalling /

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