Pharmacogenomics : methods and protocols /

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Bibliographic Details
Imprint:Totowa, N.J. : Humana Press, c2005.
Description:x, 214 p. : ill. ; 24 cm.
Language:English
Series:Methods in molecular biology, 1064-3745 ; 311
Methods in molecular biology (Clifton, N.J.) ; v. 311.
Subject:
Format: Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/5729090
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Other authors / contributors:Innocenti, Federico.
ISBN:1588294404 (alk. paper)
Notes:Includes bibliographical references and index.
Table of Contents:
  • Preface
  • Contributors
  • Part I. History and Overview
  • 1. Pharmacogenomics: Historical Perspective and Current Status
  • Part II. Functional Analysis of Gene Variation
  • 2. Transfection Assays With Allele-Specific Constructs: Functional Analysis of UDP-Glucuronosyltransferase Variants
  • 3. Snapshot of the Allele-Specific Variation in Human Gene Expression
  • 4. Genome-Wide Analysis of Allele-Specific Gene Expression Using Oligo Microarrays
  • 5. HaploChIP: An In Vivo Assay
  • Part III. Genotyping Techniques
  • 6. Aspects Influencing Genotyping Method Selection
  • 7. Denaturing High-Performance Liquid Chromatography for Mutation Detection and Genotyping
  • 8. Pyrosequencing of Clinically Relevant Polymorphisms
  • 9. Kinetic Fluorescence-Quenching Detection Assay for Allele Frequency Estimation
  • 10. Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
  • 11. Fluorescence-Based Fragment Size Analysis
  • 12. Single-Nucleotide Polymorphism Genotyping in DNA Pools
  • 13. TaqMan Genotyping of Insertion/Deletion Polymorphisms
  • Part IV. Management of Pharmacogenomic Information
  • 14. PharmGKB: The Pharmacogenetics and Pharmacogenomics Knowledge Base
  • 15. Systems for the Management of Pharmacogenomic Information
  • Index