Hedgehog-gli signaling in human disease /
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| Author / Creator: | Ruiz i Altaba, Ariel. |
|---|---|
| Imprint: | Georgetown, Tex. : Landes Bioscience/Eurekah.com ; New York, N.Y. : Springer Science+Business Media, c2006. |
| Description: | 228 p. : ill. (some col.) ; 24 cm. |
| Language: | English |
| Series: | Molecular biology intelligence unit Molecular biology intelligence unit (Unnumbered) |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/5869945 |
Table of Contents:
- Preface
- 1. How the Hedgehog Outfoxed the Crab: Interference with Hedgehog-Gli Signaling as Anti-Cancer Therapy?
- 2. The Patched Receptor: Switching On/Off the Hedgehog Signaling Pathway
- The Hedgehog Signaling Pathway
- Sequence and Functional Analysis of Ptc
- Hedgehog Lipid Modifications and Morphogen Distribution
- Reception of Hh
- Hh Internalization and Signal Transduction
- Smo Regulation by Ptc
- Ptc and Human Disease
- 3. Making a Morphogenetic Gradient
- Disp 1, A Molecule Dedicated to the Export of Shh
- Is Shh Handed Over from Cell to Cell Using an Active Mechanism?
- 4. Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signaling
- The Hair Follicle Cycle
- Interfollicular Epithelial Cells Are Competent to Induce Shh Target Genes
- Outcomes of Shh Target Gene Induction in the Skin
- Regulation of Shh Induction in a Multipotent Epithelium
- Regulation of Shh Signal Reception
- Maintenance of Shh Signaling during Tissue Morphogenesis
- Future Perspectives
- 5. Mode of PTCH1/Ptch1-Associated Tumor Formation: Insights from Mutant Ptch1 Mice
- Is Loss of Both PTCH1/Ptch1 Alleles Required for Tumor Formation?
- What Are the Modifiers of PTCH1/Ptch1-Associated Tumorigenesis?
- 6. Basal Cell Carcinomas, Hedgehog Signaling, and the Ptch1+/- Mouse
- Rhabdomyosarcomas
- Medulloblastomas
- BCCs
- 7. Gli genes and Their Targets in Epidermal Development and Disease
- Gli Genes and Epidermal Development
- Human Epidermis and the Origin of BCC
- Gli1 and Gli2 in Basal Cell Carcinoma
- The Oncogenic Nature of Gli Transcription Factors
- Regulation of Gli Expression
- Unresolved Problems and Future Perspectives
- 8. Splitting Hairs: Dissecting the Roles of Gli Activator and Repressor Functions during Epidermal Development and Disease
- The Gli Family of Transcription Factors in Hh Signaling
- Molecular Mechanisms of Embryonic and Adult Hair Development
- Shh: Stem Cells, Cell Cycle and Cancer
- 9. Shh Expression in Pulmonary Injury and Disease
- The Hedgehog Pathway
- Hedgehog Signalling in Normal Pulmonary Tissues
- Hedgehog Signalling in Injury and Disease
- Shh in the Immune System
- Hedgehogs and Pulmonary Progenitor Cells
- Shh and Type II Epithelial Cells
- 10. Human Correlates of Gli3 Function
- The Delineation of the Greig Cephalopolysyndactyly Syndrome (GCPS)
- The Molecular Basis of GCPS
- The Clinical Delineation of Pallister-Hall Syndrome (PHS)
- Animal Models of Gli3 Phenotypes
- 11. From Oligodactyly to Polydactyly: Role of Shh and Gli3 in Limb Morphogenesis
- Shh Expression and the Specification of Digit Identity
- Congenital Limb Malformations Associated with Shh Misregulation
- Shh Activity in Limb Patterning Is Mediated by Gli3
- Congenital Limb Malformations Are Associated with Gli3 Mutations
- 12. The Genetics of Indian Hedgehog
- Brachydactyly Type A1
- Acrocapitofemoral Dysplasia (ACFD)
- Comparison of Humann IHH Disorders
- IHH Animal Model
- 13. Sonic Hedgehog Signaling in Craniofacial Development
- The Face in Myth and Reality
- The Craniofacial Consequences of Disrupting SHH Signaling: The Human Experience
- Models to Study Craniofacial Development
- Craniofacial Consequences of Shh Perturbation: The Model Experience
- Embryologic Aspects of Normal Craniofacial Development: An Introduction
- Future Directions
- 14. Important Role of Shh Controlling Gli3 Functions during the Dorsal-Ventral Patterning of the Telencephalon
- Shh Signaling and Dorsal-Ventral Patterning of the Telencephalon
- Gli3 as an Activator of Dorsal Cell Types
- Gli3 as a Suppressor of Ventral Cell Type
- Importance of the Balance between Gli3 and Shh
- Future Perspectives
- 15. Regulation of Early Events in Cell Cycle Progression by Hedgehog Signaling in CNS Development and Tumorigenesis
- Mitogenic Signaling in the Developing CNS
- SHH Signaling Is Required for Growth of Cerebellar Granule Neuron Precursors and Is Etiologic in Medulloblastoma
- N-MYC as a Key Component of Hh Signaling
- 16. Modulating the Hedgehog Pathway in Diseases
- Identification of Small Molecule Hedgehog (Hh) Antagonists
- Identification of Hh Small Molecule Hh Agonists
- 17. Hedgehog Signaling in Endodermally Derived Tumors
- The Hedgehog Signaling Pathway
- Hedgehog Signaling in Gastrointestinal Tumors of the Pancreas and Colon
- Index
