Immunogenomics and human disease /
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Imprint: | Chichester, West Sussex, England ; Hoboken, NJ : John Wiley, c2006. |
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Description: | xxi, 526 p. : ill. (some col.) ; 26 cm. |
Language: | English |
Subject: | |
Format: | E-Resource Print Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/5898027 |
Table of Contents:
- Preface
- List of Contributors
- 1. Genotyping methods and disease gene identification
- 1.1. Introduction
- 1.2. Genotyping of single-nucleotide polymorphisms
- 1.3. Methods for interrogating SNPs
- 1.4. Analysis formats
- 1.5. The current generation of methods for SNP genotyping
- 1.6. The next generation
- 1.7. Classical HLA typing
- 1.8. MHC haplotypes
- 1.9. Molecular haplotyping
- 1.10. Microhaplotyping
- 1.11. MHC and disease associations
- 1.12. Conclusions
- Acknowledgements
- References
- 2. Glycomics and the sugar code: primer to their structural basis and functionality
- 2.1. Introduction
- 2.2. Lectins as effectors in functional glycomics
- 2.3. Galectins: structural principles and intrafamily diversity
- 2.4. Ligand-dependent levels of affinity regulation
- 2.5. Perspectives for galectin-dependent medical applications
- 2.6. Conclusions
- References
- 3. Proteomics in clinical research: perspectives and expectations
- 3.1. Introduction
- 3.2. Proteomics: tools and projects
- 3.3. Discussion
- 3.4. Concluding remarks
- Acknowledgements
- References
- 4. Chemical genomics: bridging the gap between novel targets and small molecule drug candidates. Contribution to immunology
- 4.1. Introduction of chemical genomics: definitions
- 4.2. Chemical microarrays
- 4.3. Small molecule and peptide probes for studying binding interactions through creating a covalent bond
- 4.4. Photochemical proteomics
- 4.5. General aspects of photoaffinity labelling
- 4.6. Photoreactive probes of biomolecules
- 4.7. Application to the immunobiology of living cells
- 4.8. Multifunctional photoprobes for rapid analysis and screening
- 4.9. Advanced application to functional proteomics
- 4.10. Summary
- References
- 5. Genomic and proteomic analysis of activated human monocytes
- 5.1. Primary human monocytes, as a model system
- 5.2. Transcriptional profiling of activated monocytes
- 5.3. Functional genomics
- 5.4. Proteomic analysis of activated human monocytes
- 6. Bioinformatics as a problem of knowledge representation: applications to some aspects of immunoregulation
- 6.1. Introduction
- 6.2. Sequences and languages
- 6.3. Three-dimensional models
- 6.4. Genomes, proteomes, networks
- 6.5. Computational tools
- 6.6. Information processing in the immune system
- 6.7. Concluding remarks
- References
- 7. Immune responsiveness of human tumours
- 7.1. Introduction
- 7.2. Defining tumour immune responsiveness
- 7.3. Studying immune responsiveness in human tumours
- 7.4. Immune responsiveness in the context of therapy
- 7.5. The spatial dimension in the quest for the target
- 7.6. Studying the receiving end - tumour as an elusive target for immune recognition
- 7.7. The role of the host in determining immune responsiveness
- 7.8. Concluding remarks
- References
- 8. Chemokines regulate leukocyte trafficking and organ-specific metastasis
- 8.1. Chemokines and chemokine receptors
- 8.2. Chemokine receptors in the organ-specific recruitment of tumour cells
- 8.3. Cancer therapy using chemokine receptor inhibitors
- 8.4. Conclusions
- References
- 9. Towards a unified approach to new target discovery in breast cancer: combining the power of genomics, proteomics and immunology
- 9.1. Introduction
- 9.2. The use of CGH and DNA microarray-based transcriptional profiling for new target discovery in breast cancer
- 9.3. The challenge of new tumour marker/target validation: traditional techniques meet new proteomics tools
- 9.4. Immunological validation of new target genes in breast cancer the emerging concept of the cancer 'immunome'
- 9.5. Future prospects: combining target discovery approaches in unified publicly accessible databases
- References
- 10. Genomics and functional differences of dendritic cell subsets
- 10.1. Introduction
- 10.2. Origin, differentiation and function of human dendritic cell subsets
- 10.3. Tissue localization of dendritic cell subsets
- 10.4. Antigen uptake by dentritic cells
- 10.5. Antigen processing and presentation by dendritic cells
- 10.6. Activation and polarization of dendritic cells
- 10.7. Enhancement of inflammatory responses by NK cells
- 10.8. Suppression of inflammatory responses by natural regulatory T cells
- 10.9. The role of dendritic cells and T-lymphocytes in tumour-specific immune responses
- References
- 11. Systemic lupus erythematosus: new ideas for diagnosis and treatment
- 11.1. Introduction
- 11.2. Strategies for identifying diagnostic markers
- 11.3. Strategies for gene therapy for SLE
- 11.4. Conclusion and future direction
- References
- 12. Immunogenetics of experimentally induced arthritis
- 12.1. Rheumatoid arthritis in humans and murine proteoglycan-induced arthritis: introduction
- 12.2. Genetic linkage analysis of PGIA
- 12.3. Transcriptome picture of the disease: gene expression during the initiation and progression of joint inflammation
- 12.4. Conclusions
- References
- 13. Synovial activation in rheumatoid arthiritis
- 13.1. Introduction
- 13.2. Synovial activation in rheumatoid arthritis
- 13.3. Conclusions/perspectives
- References
- 14. T cell epitope hierarchy in experimental autoimmune models
- 14.1. Introduction
- 14.2. Immunodominance and crypticity
- 14.3. Epitope spreading (endogenous self-priming)
- 14.4. Degenerate T cell epitope recognition
- 14.5. The self-reactive TCR repertoire
- 14.6. Thymic antigen presentation
- 14.7. Peripheral antigen presentation
- 14.8. Epitope hierarchy in experimental autoimmune encephalomyelitis
- 14.9. Epitope hierarchy in aggrecan-induced murine arthritis
- 14.10. Summary
- References
- 15. Gene-gene interaction in immunology as exemplified by studies on autoantibodies against 60 kDa heat-shock protein
- 15.1. Introduction
- 15.2. Basic features of gene-gene interactions
- 15.3. How to detect epistasis
- 15.4. Autoimmunity to heat-shock proteins
- 15.5. Epistatic effect in the regulation of anti-HSP6 autoantibody levels
- 15.6. Conclusions
- Appendix
- References
- 16. Histamine genomics and metabolomics
- 16.1. Introduction
- 16.2. Chemistry
- 16.3. Biosynthesis and biotransformation
- 16.4. Histidine decarboxylase - gene and protein
- 16.5. Catabolic pathways of histamine
- 16.6. Histamine receptors
- 16.7. Histamine and cytokines, relation to the T cell polarization of the immune response
- 16.8. Histamine and tumour growth
- 16.9. Histamine research: an insight into metabolomics, lessons from HDC-deficient mice
- 16.10. Histamine genomics on databases
- References
- 17. The histamine H[subscript 4] receptor: drug discovery in the post-genomic era
- 17.1. Introduction
- 17.2. Cloning of H[subscript 3]R and H[superscript 4]R
- 17.3. Generation of H[subscript 4]R-specific antagonists
- 17.4. High-throughput screening
- 17.5. Functional sludies
- 17.6. Future prospects
- References
- 18. Application of microarray technology to bronchial asthma
- 18.1. Introduction
- 18.2. Lung tissue as 'source'
- 18.3. Particular cell as 'source'
- 18.4. Conclusions
- Acknowledgements
- References
- 19. Genomic investigation of asthma in human and animal models
- 19.1. Introduction
- 19.2. Methods for localization of asthma susceptibility genes
- 19.3. Results of the association studies and genome-wide screens in humans
- 19.4. Animal models of asthma
- 19.5. Concluding remarks
- References
- 20. Primary immunodeficiencies: genotype-phenotype correlations
- 20.1. Introduction
- 20.2. Immunodeficiency data services
- 20.3. Genotype-phenotype correlations
- 20.4. ADA deficiency
- 20.5. RAG1 and RAG2 deficiency
- 20.6. AID deficiency
- 20.7. WAS
- 20.8. XLA
- 20.9. Why GP correlations are not more common
- References
- 21. Transcriptional profiling of dentritic cells in response to pathogens
- 21.1. Transcriptional profiling to study the complexity of the immune system
- 21.2. DC subsets and functional studies
- 21.3. DC at the intersection between innate and adaptive immunity
- 21.4. DC and infectious diseases
- 21.5. DC and bacteria interaction
- 21.6. DC and virus interaction
- 21.7. DC and parasite interaction
- 21.8. Leishmania mexicana molecular signature
- 21.9. Conclusions
- References
- 22. Parallel biology: a systematic approach to drug target and biomarker discovery in chronic obstructive pulmonary disease
- 22.1. Introduction
- 22.2. Genome research is a specific application of parallel biology often regarded as systems biology
- 22.3. Chronic obstructive pulmonary disease
- 22.4. Goals of the study
- 22.5. Methods
- 22.6. Results
- Appendix
- References
- 23. Mycobacterial granulomas: a genomic approach
- 23.1. Introduction
- 23.2. Initial infection of macrophage
- 23.3. Mycobacterial gene expression in the host
- 23.4. Host genes important to granuloma formation
- 23.5. Granulomatous inflammation as an ecological system
- References
- Index