The Oxford textbook of clinical pharmacology and drug therapy /
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| Author / Creator: | Grahame-Smith, David Grahame |
|---|---|
| Imprint: | Oxford ; New York : Oxford University Press, 1984. |
| Description: | xv, 843 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Oxford medical publications |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/609912 |
Table of Contents:
- A note about drug nomenclature
- Consulting authors
- Section 1. Clinical pharmacology: the scientific basis of drug therapy
- 1. The four processes of drug therapy
- 1.1. The pharmaceutical process
- 1.2. The pharmacokinetic process
- 1.3. The pharmacodynamic process
- 1.4. The therapeutic process
- 2. The pharmaceutical process: is the drug getting into the patient?
- 2.1. Patient compliance/concordance
- 2.2. Systemic availability (bioavailability)
- 2.3. Special drug formulations
- 3. The pharmacokinetic process: is the drug getting to its site of action?
- 3.1. Drug absorption and systemic availability
- 3.2. Drug distribution
- 3.3. Drug metabolism
- 3.4. Drug excretion
- 3.5. Simple pharmacokinetic calculations
- 3.6. The mathematics of pharmacokinetics
- 4. The pharmacodynamic process: is the drug producing the required pharmacological effect?
- 4.1. The types of pharmacological actions of drugs
- 4.2. Stereoisomerism and drug action
- 4.3. Graded responses to drugs: the dose-responsive curve in drug therapy
- 5. The therapeutic process: is the pharmacological being translated into a therapeutic effect?
- 5.1. Translation of the pharmacological effect of a drug into a therapeutic effect during short-term drug therapy
- 5.2. Translation of the pharmacological effect of a drug into a therapeutic effect during long-term drug therapy
- 5.3. The aims of drug therapy
- 6. Practical applications of the analysis of drug therapy
- 6.1. The application of pharmacokinetics to the planning of drug dosage regimens
- 6.2. The application of the processes of drug therapy in analysing failure to respond to treatment
- 7. Monitoring drug therapy
- 7.1. Monitoring the therapeutic effects of drugs
- 7.2. Monitoring the pharmacodynamic effects of drugs
- 7.3. Monitoring drug pharmacokinetics (plasma concentration measurement)
- 8. Pharmacogenetics and pharmacogenomics
- 8.1. Pharmacokinetic genetic variations
- 8.2. Pharmacodynamic genetic variations
- 9. Adverse reactions to drugs
- 9.1. History
- 9.2. Incidence of adverse drug reactions
- 9.3. Classification of adverse drug reactions
- 9.4. Dose-related adverse drug reactions
- 9.5. Non-dose-related adverse drug reactions
- 9.6. Long-term and withdrawal effects causing adverse drug reactions
- 9.7. Delayed effects causing adverse drug reactions
- 9.8. Surveillance methods used in detecting adverse drug reactions
- 10. Drug interactions
- 10.1. Incidence of significant drug interactions
- 10.2. Drugs likely to be involved in interactions
- 10.3. Pharmaceutical interactions
- 10.4. Pharmacokinetic interactions
- 10.5. Pharmacodynamic interactions
- 10.6. Lists of clinically important drug interactions
- 11. Drug therapy in young and old people
- 11.1. Drug therapy in young people
- 11.2. Drug therapy in old people
- 12. Drug therapy and reproduction
- 12.1. Hormonal contraception
- 12.2. Hormone replacement therapy
- 12.3. The treatment of infertility
- 12.4. Drug therapy during pregnancy
- 12.5. Drug therapy in the termination of pregnancy and in the management of pre-term labour and labour
- 12.6. Drug therapy and breastfeeding
- 13. Patient compliance/concordance
- 13.1. Factors that affect compliance
- 13.2. Methods of measuring compliance
- 13.3. Methods of improving compliance
- 14. Placebos
- 14.1. Uses and abuses of placebos
- 14.2. Factors that influence the response to placebos
- 14.3. Mode of action of placebos
- 14.4. Adverse effects of placebos
- 15. Drug discovery and development: the pharmaceutical industry and the regulatory authorities
- 15.1. Drug discovery
- 15.2. Drug development
- 15.3. Post-marketing surveillance
- 15.4. Advertising
- 15.5. Regulatory authorities
- 15.6. Local drug and therapeutics committees
- 15.7. Drug costs
- 16. Drug trials
- 16.1. Definition of a clinical trial
- 16.2. The conduct of a clinical trial
- 16.3. Ethics
- 17. The drug history and the clinical examination and investigation of drug effects
- 17.1. Taking the drug history
- 17.2. Clinical examination and investigation of drug effects
- 17.3. The importance of good records and communication
- Section 2. Practical prescribing
- 18. Principles of prescribing
- 18.1. The benefit:risk ratio in prescribing
- 18.2. Evidence-based medicine
- 18.3. How to choose a drug
- 19. How to write a prescription
- 19.1. Practical prescription writing
- 19.2. Proprietary names versus approved names
- 19.3. Prescribing controlled drugs
- 19.4. Repeat prescribing
- 19.5. Abbreviations
- 20. Sources of information on drugs
- 20.1. Pharmaceutical information
- 20.2. Pharmacokinetics
- 20.3. Pharmacological effects of drugs
- 20.4. Therapeutic
- 20.5. Pharmacogenetics
- 20.6. Adverse effects of drugs
- 20.7. Drug interactions
- 20.8. Clinical trials
- 20.9. Patient compliance
- 20.10. Prescribing information
- 20.11. Computerized databases
- 20.12. Drug information services
- 20.13. Bibliography
- Section 3. The drug therapy of disease
- 21. Introduction to drug therapy
- 22. The drug therapy of infectious diseases
- 22.1. Antibacterial drugs: the treatment of bacterial infections
- 22.2. Chemotherapy of viral infections
- 22.3. Chemotherapy of protozoal infections
- 22.4. Chemotherapy of helminthic infections
- 22.5. Chemotherapy of trematode infections
- 22.6. Chemotherapy of fungal infections
- 22.7. Prevention of infections using vaccines and immunoglobulins
- 22.8. The drug treatment of sexually transmitted diseases
- 23. The drug therapy of cardiovascular disorders
- 23.1. Hypertension
- 23.2. Angina pectoris
- 23.3. Acute myocardiat infarction
- 23.4. Cardiac arrhythmias
- 23.5. Cardiac failure
- 23.6. Infective endocarditis
- 23.7. Venous thromboembolic disease
- 24. The drug therapy of respiratory diseases
- 24.1. The use of oxygen in respiratory disorders
- 24.2. Cough
- 24.3. Pneumonias
- 24.4. Chronic obstructive lung disease
- 24.5. Bronchial asthma
- 24.6. Pulmonary tuberculosis
- 24.7. Inflammatory lung disorders
- 24.8. Cystic fibrosis
- 24.9. Drug-induced respiratory disorders
- 25. The drug therapy of gastrointestinal, hepatic, and biliary disorders
- 25.1. Antacids
- 25.2. Antiemetics
- 25.3. Peptic ulceration
- 25.4. Laxatives
- 25.5. Antidiarrhoeal drugs
- 25.6. Irritable bowel syndrome
- 25.7. Gastrointestinal infections
- 25.8. Ulcerative colitis
- 25.9. Crohn's disease
- 25.10. Drugs and the liver
- 25.11. Drug therapy in the treatment of chronic liver disease
- 25.12. Drug treatment of gallstones
- 26. Drugs and the kidney and the drug therapy of renal, urinary tract, and prostatic disorders
- 26.1. Diuretic therapy
- 26.2. Potassium depletion
- 26.3. Hyperkalaemia
- 26.4. The place of drugs in the management of acute renal insufficiency
- 26.5. The place of drugs in the management of chronic renal insufficiency
- 26.6. The drug treatment of glomerulonephritis
- 26.7. Drugs in the treatment of urinary tract infection
- 26.8. Drug treatment of urinary calculi
- 26.9. Drugs and the urinary bladder: the treatment of incontinence, detrusor instability, and enuresis
- 26.10. Drug therapy of tumours of the kidney
- 26.11. Drug therapy of prostatic disease
- 26.12. Drug-induced renal damage
- 26.13. Drugs and dialysis
- 27. The drug therapy of endocrine and metabolic disorders
- 27.1. Disorders of the pituitary gland
- 27.2. Disorders of the adrenal gland
- 27.3. Disorders of the thyroid gland
- 27.4. Disorders of calcium metabolism
- 27.5. Diabetes mellitus
- 27.6. Disorders of lipid metabolism
- 27.7. The management of obesity
- 28. The drug therapy of blood disorders
- 28.1. Anaemias
- 28.2. Myeloproliferative disorders
- 28.3. Lymphoproliferative disorders
- 28.4. Acute leukaemias
- 28.5. Monoclonal gammopathies
- 28.6. Drug-induced blood dyscrasias
- 28.7. Complications of blood transfusion
- 28.8. Blood substitutes
- 29. The drug therapy of disorders of bones and joints
- 29.1. Arthritis
- 29.2. Gout and hyperuricaemia
- 29.3. Musculoskeletal disorders caused by drugs
- 29.4. Paget's disease of bone
- 29.5. The prevention and treatment of postmenopausal osteoporosis
- 30. The drug therapy of neurological disorders
- 30.1. Meningitis and encephalitis
- 30.2. Parkinson's disease and Parkinsonism
- 30.3. Epilepsy
- 30.4. Migraine
- 30.5. Myasthenia gravis
- 30.6. Muscle spasticity
- 30.7. Vertigo
- 30.8. Trigeminal neuralgia
- 30.9. Drug-induced movement disorders
- 31. The drug therapy of psychiatric disorders
- 31.1. Mechanisms of action of drugs used in psychiatric disorders
- 31.2. The use of psychotropic drugs
- 32. The relief of pain
- 32.1. Anatomical and neuropharmacological mechanisms underlying pain sensation
- 32.2. Mechanisms of action of analgesics
- 32.3. Principles underlying the use of analgesics in the treatment of pain
- 32.4. The practical use of analgesics
- 32.5. The treatment of intractable pain in terminal malignant disease
- 32.6. Postoperative pain
- 33. General anaesthesia and local anaesthetics
- 33.1. Premedication
- 33.2. Induction of anaesthesia
- 33.3. Muscle relaxants
- 33.4. Maintenance of anaesthesia
- 33.5. Postoperative medication
- 33.6. Local anaesthetics
- 34. Drug dependence and abuse
- 34.1. Factors that predispose to drug dependence
- 34.2. Opiates
- 34.3. Cocaine and amphetamines (including Ecstasy)
- 34.4. Cannabis
- 34.5. LSD and other psychedelic drugs
- 34.6. Solvents and nitrites
- 34.7. Alcohol
- 34.8. Benzodiazepines
- 34.9. Barbiturates
- 34.10. Anabolic steroids
- 34.11. Tobacco (nicotine)
- 34.12. Accounts of drug dependence
- 35. The management of poisoning
- 35.1. The immediate management of the acutely ill patient
- 35.2. The detailed management of poisoning
- 35.3. Sources of information
- 35.4. Agents used in the treatment of poisoning
- 36. The principles of cancer chemotherapy
- 36.1. Tumour responsiveness to chemotherapy
- 36.2. The actions of chemotherapeutic drugs relevant to the clinical uses
- 36.3. Clinical evaluation of tumours before and after treatment
- 36.4. Combination chemotherapy
- 36.5. Regimens for cancer chemotherapy
- 36.6. Adverse effects of drugs used in cancer chemotherapy
- 36.7. The practical use of cytotoxic drugs
- 37. Immunosuppression and the drug therapy of allergies, connective tissue disorders, and primary immunodeficiencies
- 37.1. Immune disease: pathogenesis and mechanisms of action of drugs
- 37.2. The use of glucocorticoids as anti-inflammatory, antiallergic, and immunosuppressive agents
- 37.3. The drug therapy of allergic and autoimmune disorders
- 37.4. The management of primary immunodeficiences
- 37.5. Immunosuppression in tissue and organ transplantation
- Section 4. Pharmacopoeia
- Introductory notes
- Index to drugs listed in the pharmacopoeia
- Pharmacopoeia
- General index
