Deoxynucleoside analogs in cancer therapy /
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| Imprint: | Totowa, N.J. : Humana Press, c2006. |
|---|---|
| Description: | xiii, 476 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Cancer drug discovery and development |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/6240363 |
Table of Contents:
- Preface
- Contributors
- 1. Nucleoside Transport Into Cells: Role of Nucleoside Transporters SLC28 and SLC29 in Cancer Chemotherapy
- 2. The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation
- 3. Deoxynucleoside Kinases and Their Potential Role in Deoxynucleoside Cytotoxicity
- 4. Nucleotidases and Nucleoside Analog Cytotoxicity
- 5. Pumping Out Drugs: The Potential Impact of ABC Transporters on Resistance to Base, Nucleoside, and Nucleotide Analogs
- 6. Cytosine Arabinoside: Metabolism, Mechanisms of Resistance, and Clinical Pharmacology
- 7. Clofarabine: Mechanisms of Action, Pharmacology, and Clinical Investigations
- 8. L-Nucleosides as Chemotherapeutic Agents
- 9. Troxacitabine (Troxatyl): A Deoxycytidine Nucleoside Analog With Potent Antitumor Activity
- 10. 9-[Beta]-D-Arabinofuranosylguanine
- 11. Gemcitabine: Mechanism of Action and Resistance
- 12. Clinical Activity of Gemcitabine as a Single Agent and in Combination
- 13. Nucleoside Radiosensitizers
- 14. NONMEM Population Models of Cytosine Arabinoside and Fludarabine Phosphate in Pediatric Patients With Leukemia
- 15. The cycloSal-Nucleotide Delivery System: Development of Chemical Trojan Horses as Antiviral Agents
- 16. Purine and Pyrimidine-Based Analogs and Suicide Gene Therapy
- 17. 3[prime]-Deoxy-3[prime]-Fluorothymidine as a Tracer of Proliferation in Positron Emission Tomography
- Index
