Crossroads between innate and adaptive immunity /

Crossroads between innate and adaptive immunity /

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Bibliographic Details
Meeting name:Crossroads Between Innate and Adaptive Immunity Conference (1st : 2005 : Rhodes, Greece)
Imprint:New York : Springer, c2007.
Description:xx, 232 p., [1] leaf of plates : ill. (some col.) ; 25 cm.
Language:English
Series:Advances in experimental medicine and biology, 0065-2598 ; v. 590
Subject:
Natural immunity -- Congresses.
Immune response -- Regulation -- Congresses.
Immunity, Natural -- congresses.
Immunity, Active -- Congresses.
Immunity -- physiology -- Congresses.
T-Lymphocytes -- immunology -- Congresses.
Neoplasms -- immunology -- congresses.
Immune response -- Regulation.
Natural immunity.
Conference papers and proceedings.
Format: E-Resource Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/6243856
Hidden Bibliographic Details
Other authors / contributors:Katsikis, Peter D.
Pulendran, B. (Bali)
Schoenberger, Stephen P.
ISBN:9780387348131 (acid-free paper)
0387348131 (acid-free paper)
9780387348148 (electronic bk.)
038734814X (electronic bk.)
Notes:"Proceedings of the First Crossroads between Innate and Adaptive Immunity Conference, held in Rhodes, Greece, October 9-14, 2005."--T.p. verso.
Includes bibliographical references and index.
Table of Contents:
  • List of Contributors
  • 1. Signal Transduction in DC Differentiation: Winged Messengers and Achilles' Heel
  • 1. Introduction
  • 2. Dendritic Cell Functional Diversity
  • 3. DC Progenitors
  • 4. Winged Messengers - Signaling Pathways that Drive DC Differentiation
  • 4.1. Extracellular Stimuli
  • 4.2. Intracellular Signal Transduction
  • 5. Achilles' Heel - Subversion of DC Differentiation by Pathogen-Mediated Disruption of Signal Transduction Pathways
  • 5.1. Yersinia and the Disruption of Intracellular Signaling Pathways
  • 5.2. Yersinia and DC Differentiation
  • 6. Concluding Remarks
  • 7. References
  • 2. Shaping Naive and Memory CD8+T Cell Responses in Pathogen Infections through Antigen Presentation
  • 1. Introduction
  • 2. Dendritic Cells of Spleen and Lymph Nodes
  • 3. Role of Dendritic Cells in Pathogen Responses
  • 3.1. Priming Naive T Cells
  • 3.2. Identifying the Main Movers and Shakers in Infection
  • 3.3. Dendritic Cell Subsets in Pathogen Infections
  • 3.4. Amplification of Memory CD8+T Cells in Secondary Infections
  • 4. Conclusions
  • 5. Acknowledgments
  • 6. References
  • 3. Understanding the Role of Innate Immunity in the Mechanism of Action of the Live Attenuated Yellow Fever Vaccine 17D
  • 1. Introduction: A Historical Perspective
  • 2. Understanding the Innate Immune Mechanism of Action of YF-17D
  • 3. Concluding Remarks
  • 4. Acknowledgments
  • 5. References
  • 4. The Function of Local Lymphoid Tissues in Pulmonary Immune Responses
  • 1. Lymph Node Structure and Development
  • 2. Role of Local Lymphoid Organs in Pulmonary Immunity
  • 2.1. Structure and Function of Nasal-Associated Lymphoid Tissue (NALT)
  • 2.2. Pulmonary Immune Responses in the Absence of Secondary Lymphoid Organs
  • 2.3. Structure and Function of Bronchus-Associated Lymphoid Tissue (BALT)
  • 2.4. Does iBALT Confer Antiinflammatory Properties on Local Immune Responses?
  • 3. Conclusions and Future Directions
  • 4. Acknowledgments
  • 5. References
  • 5. The Yin and Yang of Adaptive Immunity in Allogeneic Hematopoietic Cell Transplantation: Donor Antigen-Presenting Cells Can Either Augment or Inhibit Donor T Cell Alloreactivity
  • 1. Introduction
  • 2. Materials and Methods
  • 2.1. Mice
  • 2.2. LBRM Tumor Cell Line
  • 2.3. Donor Cell Preparations
  • 2.4. BM CD11b Depletion and Splenic T Cell Purification
  • 2.5. Recipient Mice Conditioning
  • 2.6. BMT and Leukemia Challenge
  • 2.7. Analyses of DC Subsets and DC Precursors in BM and Spleen Grafts
  • 2.8. Analyses of Hematopoietic Engraftment of Transplant Recipients
  • 2.9. Serum Gamma Interferon (IFN-[gamma]) and Tumor Necrosis Factor-Alpha (TNF-[alpha]) Enzyme-Linked Immunosorbent Assay (ELISA)
  • 2.10. Assessments of Survival and GvHD in Transplant Recipients
  • 2.11. Statistical Analyses
  • 3. Results
  • 3.1. MACs Depletion of CD11b[superscript +] Cells in the BM Graft Does not Affect Stem Cell Content
  • 3.2. Transplanting Manipulated BM Grafts in the Absence of Added Splenocytes Did not Lead to Graft Rejection or GvHD
  • 3.3. CD11b-Depleted BM Grafts Combined with Low-Dose Splenocytes or Splenic T Cells Led to Slight Enhancement of Non-Lethal GvHD in Recipients of Allogeneic BMT
  • 3.4. CD11b[superscript +] Cell-Enriched BM Grafts Combined with Low-Dose Splenocytes or Splenic T Cells Inhibited GvHD in Recipients of Allogeneic BMT
  • 3.5. No Combinations of Unmanipulated BM and Splenocytes Produced a GvL Effect without also Causing Lethal GvHD
  • 3.6. The Combination of CD11b-Depleted BM and Low-Dose Donor Splenocytes Led to a Durable GvL Effect without GvHD
  • 3.7. Recipients of CD11b-Depleted BM Grafts Had Increased Numbers of Donor Spleen-Derived Memory T Cells in the Blood Post-Transplant
  • 3.8. Recipients of CD11b-Depleted Allogeneic BMT Had Increased Levels of Serum IFN-[gamma] at Day +30 Post-BMT
  • 4. Discussion
  • 5. Acknowledgments
  • 6. References
  • 6. It's Only Innate Immunity But I Like It
  • 1. Introduction
  • 2. The Immunoregulatory Role of NK Cells: Crosstalk between NK, MDDC, and PDC
  • 3. Crosstalk between Innate and Adaptive Immune Responses
  • 4. Involvement of Neutrophils in the Regulation of Adaptive Immune Responses through Interactions with Other Innate Effector Cells
  • 5. Other Innate Cells Such as Mast Cells or Eosinophils Are Important in the Early Phases of Innate Immune Responses
  • 6. Concluding Remarks
  • 7. Ackowledgments
  • 8. References
  • 7. Innate Tumor Immune Surveillance
  • 1. Introduction
  • 2. Type I Interferon
  • 3. NKG2D
  • 4. Cytokines that Act via NKG2D
  • 5. Acknowledgments
  • 6. References
  • 8. Regulation of Adaptive Immunity by Cells of the Innate Immune System: Bone Marrow Natural Killer Cells Inhibit T Cell Proliferation
  • 1. Introduction
  • 2. Regulatory Function of NK Cells
  • 3. NK Cells Inhibit by a Non-Cytotoxic Mechanism
  • 4. NK Cells Inhibit Cell Cycle Progression
  • 5. Bone Marrow-Derived NK Cells Have Unique Function
  • 6. Role of NK Cells in Immune Homeostasis
  • 7. Acknowledgments
  • 8. References
  • 9. Induction and Maintenance of CD8+T Cells Specific for Persistent Viruses
  • 1. Persistent Viruses Are Prevalent in Human and Mice
  • 2. General Effects of Persistent Viruses on the Host Immune System
  • 3. Generation of CD8+ Memory T Cells
  • 4. Function of Memory CD8+ T Cells Specific for Persistent Viruses
  • 5. Phenotype of Memory CD8+ T Cells Specific for Persistent Viruses
  • 6. Maintenance of Memory CD8+ T Cells Specific for Persistent Viruses
  • 7. Regulation of IL-7R[alpha] Expression by the Presence of Antigen
  • 8. Concluding Remarks
  • 9. References
  • 10. Germinal Center-Derived B Cell Memory
  • 1. Introduction
  • 2. Materials and Methods
  • 2.1. Mice and Immunizations
  • 2.2. [Beta]-Galactosidase Detection, Antibodies, and Flow Cytometry
  • 2.3. ELISPOT Assay
  • 2.4. Cell Sorting and Adoptive Transfers
  • 2.5. PCR and DNA Sequencing
  • 2.6. Statistics
  • 3. Results
  • 3.1. Generation of Germinal Center-Cre Transgenic Mice
  • 3.2. Splenic [Beta]-gal Expression Is Induced upon Immunization
  • 3.3. [Beta]-Galactosidase Expression Does not Mark All GC B Cells
  • 3.4. [Beta]-gal[superscript +] GC B Cells Contain Mutated [lambda][subscript 1] V Regions
  • 3.5. Hypermutated [Beta]-gal[superscript +] Memory B Cells Transfer Ag Recall Responses
  • 4. Conclusion
  • 5. References
  • 11. CD28 and CD27 Costimulation of CD8+ T Cells: A Story of Survival
  • 1. Introduction
  • 2. Classical and Alternative Costimulation
  • 3. T Cell Development
  • 4. Antigen-Specific T Cell Responses
  • 5. Memory, Antigenic Rechallenge, and Secondary Responses
  • 6. Summary and Conclusions
  • 7. References
  • 12. CD38: An Ecto-Enzyme at the Crossroads of Innate and Adaptive Immune Responses
  • 1. Introduction
  • 2. CD38 Regulates Innate and Adaptive Immune Responses
  • 2.1. CD38 Regulates Neutrophil Migration and Lung Inflammatory Responses
  • 2.2. CD38 Regulates Dendritic Cell Trafficking in Vitro and in Vivo
  • 2.3. CD38 Regulates T Cell-Dependent Immune Responses
  • 3. CD38 Modulates Chemokine Receptor Signaling by Producing Calcium Mobilizing Metabolites
  • 4. Conclusions and Future Directions
  • 4.1. Unresolved Questions
  • 4.2. Model
  • 5. Acknowledgments
  • 6. References
  • 13. Vascular Leukocytes: A Population with Angiogenic and Immunossuppressive Properties Highly Represented in Ovarian Cancer
  • 1. Physiological Angiogenesis vs. Pathological Angiogenesis
  • 2. Endothelial Progenitors and Neoangiogenesis
  • 3. Hematopoietic Cells Participate in Neoangiogenesis
  • 4. Antigen-Presenting Cells as Endothelial Cells
  • 5. Tumor Angiogenesis
  • 6. Vascular Leukocytes
  • 7. Vascular Leukocytes and Antitumor Immune Response
  • 8. Final Remarks
  • 9. Acknowledments
  • 10. References
  • 14. CD4+ T Cells Cooperate with Macrophages for Specific Elimination of MHC Class II-Negative Cancer Cells
  • 1. Introduction
  • 2. CD4+ T Cells Help CD8+ T Cells to Kill Tumor Cells
  • 3. CD4+ T Cells Can Reject Tumors in the Absence of CD8+ T Cells
  • 4. Cancer Immunotherapy by Adoptive Transfer of Tumor-Specific CD4+ T Cells
  • 5. CD4+ T Cells in Cancer Immunosurveillance
  • 5.1. Injection of Tumor Cells in Matrigel
  • 5.2. Naive Tumor-Specific CD4+ T Cells Become Activated in Draining Lymph Nodes (LN), Migrate to the Incipient Tumor Site and Secrete Cytokines
  • 5.3. Massive Recruitment of Host Macrophages toward the Injected Myeloma Cells
  • 5.4. Tumor-Specific CD4+ T Cells Activate Matrigel-Infiltrating Macrophages
  • 5.5. IFN[gamma] Is Critical for T Cell-Mediated Macrophage Activation and Tumor Rejection
  • 5.6. T Cell-Activated Macrophages Suppress Tumor Cell Growth
  • 6. Conclusions
  • 7. Acknowledgments
  • 8. References
  • 15. Receptors and Pathways in Innate Antifungal Immunity: The Implication for Tolerance and Immunity to Fungi
  • 1. Introduction
  • 2. What and Which Are Opportunistic Fungal Pathogens?
  • 3. The Immune Response to Fungi: From Microbe Sensing to Host Defencing
  • 4. Sensing Fungi
  • 5. Tuning the Adaptive Immune Responses: the Instructive Role of DCs
  • 6. DCs as Tolerance Mediators via Tryptophan Catabolism
  • 7. Dampening Inflammation and Allergy to Fungi through Treg
  • 8. Looking Forward
  • 9. Acknowledgments
  • 10. References
  • Author Index
  • Subject Index
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