Immunogenetics of autoimmune disease /

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Bibliographic Details
Imprint:Georgetown, Tex. : Landes Bioscience/Eurekah.com ; New York : Springer Science+Business Media, c2006.
Description:158 p. : ill. (some col.) ; 24 cm.
Language:English
Series:Medical intelligence unit
Medical intelligence unit (Unnumbered : 2003)
Subject:
Format: Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/6647621
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Other authors / contributors:Oksenberg, Jorge R.
Brassat, David.
ISBN:0387360042 (alk. paper)
9780387360041 (alk. paper)
Notes:Includes bibliographical references and index.
Table of Contents:
  • Preface
  • 1. HLA and Autoimmunity: Structural Basis of Immune Recognition
  • General Structural Features of MHC Class II Molecules
  • Structural Properties of HLA-DR Molecules Associated with Human Autoimmune Diseases
  • Structure and Function of HLA-DQ Molecules That Confer Susceptibility to Type 1 Diabetes and Celiac Disease
  • Presentation of Deamidated Gliadin Peptides by HLA-DQ8 and HLA-DQ2 in Celiac Disease
  • Disease-Associated MHC Class II Molecules and Thymic Repertoire Selection
  • 2. Genomic Variation and Autoimmune Disease
  • Study Design and Methods of Linkage Analysis
  • Study Design for Association Analysis
  • Population-Based Association Analysis Methods
  • Genetic Markers and Detection Methods
  • Genetic Studies of Autoimmune Disorders
  • New Approaches to Genome Wide Screening to Detect Disease Associations
  • 3. Endocrine Diseases: Type I Diabetes Mellitus
  • The HLA Region in T1D Susceptibility
  • Non HLA Genes in T1D Susceptibility
  • Additional Candidate Genes
  • Vitamin D Receptor
  • EIF2AK3
  • PTPN22
  • SUMO4
  • 4. Endocrine Diseases: Graves' and Hashimoto's Diseases
  • Genetic Epidemiology of AITD
  • Susceptibility Genes in AITD Immune Related Genes
  • Thyroid Associated Genes
  • The Effect of Ethnicity on the Development of AITD
  • Mechanisms by Which Genes Can Induce Thyroid Autoimmunity
  • 5. Central and Peripheral Nervous System Diseases
  • Multiple Sclerosis
  • Myasthenia Gravis
  • Guillain Barre Syndrome
  • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
  • Narcolepsy
  • Serological Typing Studies
  • HLA-DQB1*0602
  • Complementation of HLA-DQA1 and DQB1
  • Sequencing of HLA Alleles
  • Other HLA Protecting or Favorizing Genes
  • 6. Immunogenetics of Rheumatoid Arthritis, Systemic Sclerosis and Systemic Lupus Erythematosus
  • Rheumatoid Arthritis (RA)
  • Scleroderma and Systemic Sclerosis (SSc)
  • HLA Associations with SSc and SSc Related Autoantibodies
  • Systemic Lupus Erythematosus (SLE)
  • 7. Gastroenterologic and Hepatic Diseases
  • Inflammatory Bowel Diseases
  • Celiac Disease
  • Autoimmune Hepatitis
  • 8. Inflammatory Myopathies: Dermatomyositis, Polymyositis and Inclusion Body Myositis
  • Clinical Aspects
  • Histopathology
  • Immunopathogenesis
  • 9. Hematologic Diseases: Autoimmune Hemolytic Anemia and Immune Thrombocytopenic Purpura
  • Autoimmune Hemolytic Anemia
  • Immune Thrombocytopenic Purpura
  • Genetic Control of AEA in AIHA
  • HLA Susceptibility Genes and ITP
  • Genetic Alterations in the Control of T Cell Activation
  • Defective Lymphocyte Apoptosis
  • Fc[gamma] Receptor Polymorphisms in ITP
  • Erythrocyte CD47 and Autoimmune Hemolytic Anemia
  • 10. Genetics of Autoimmune Myocarditis
  • The Clinical Impact of Autoimmune Heart Disease
  • Coxsackievirus B3 (CB3) Induced Cardiomyopathy Is an Autoimmune Disease
  • Genetic Influence on Autoimmune Heart Disease
  • Study of Mechanism of Autoimmunity through Identification of Susceptibility Genes
  • Loci Which Influence Autoimmune Myocarditis Are Also Involved in Other Autoimmune Diseases in the A vs. C57BL/6 (B) Murine Model
  • Sensitivity to Apoptosis May Influence Development of Autoimmune Myocarditis
  • Autoimmune Myocarditis in the DBA/2 Mouse Model-Same Phenotypic Disease via Different Mechanisms and Different Loci
  • Index