Animal cell technology : from biopharmaceuticals to gene therapy /

Over the last 20 years, animal cell culture has become an increasingly important part of the biopharmaceutical industry. About half of the approximately 500 biopharmaceutical products currently undergoing clinical trials are produced by animal cell culture. The 43 contributing authors of this volume edited by Castilho (Federal Univ. of Rio de Janeiro) and colleagues review the history and technical aspects of animal cell technology. Topics include cloning and expression of proteins in animal cells, cell metabolism, culture media, bioreactor design, monitoring and control of cell culture growth, cell separation, product purification, quality control, regulatory issues, and intellectual property. Additional chapters cover the types of products produced by animal cell culture, including recombinant therapeutic proteins, monoclonal antibodies, viral vaccines, bioinsecticides, stem cells, and gene therapy products. The information is detailed and up-to-date with extensive references. Summing Up: Recommended. Upper-division undergraduate through professional biotechnology collections. C. A. Klevickis James Madison University