Mitochondria and oxidative stress in neurodegenerative disorders /

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Bibliographic Details
Imprint:Boston : Blackwell, 2008.
Description:xii, 414 p. : ill. ; 26 cm.
Language:English
Series:Annals of the New York Academy of Sciences ; vol. 1147
Subject:
Format: E-Resource Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/7481412
Hidden Bibliographic Details
Other authors / contributors:Gibson, Gary E.
Ratan, Rajiv R.
Beal, M. Flint.
ISBN:9781573317139
1573317136
Notes:Includes bibliographical references.
Also available on the Internet.
Table of Contents:
  • Preface
  • Part I. Mitochondrial Genetics and Neurodegenerative Diseases
  • A Mitochondrial Etiology of Neurodegenerative Diseases: Evidence from Parkinson's Disease
  • Mitochondrial DNA Mutations in Disease, Aging, and Neurodegeneration
  • What Have PINK1 and HtrA2 Genes Told Us about the Role of Mitochondria in Parkinson's Disease?
  • Part II. Oxidant Actions and Production in Cells
  • The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling
  • Oxidative Stress and Energy Crises in Neuronal Dysfunction
  • The Nrf2-ARE Pathway: An Indicators and Modulator of Oxidative Stress in Neurodegeneration
  • Part III. Evidence for Oxidant Damage in Brains
  • Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy: Lights and Shadows
  • Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants
  • Oxidative Stress in Parkinson's Disease: A Mechanism of Pathogenic and Therapeutic Significance
  • Part IV. Antioxidant Treatments
  • Mitochondria-Targeted Antioxidants in the Treatment of Disease
  • Development of Mitochondria-targeted Aromatic-cationic Peptides for Neurodegenerative Diseases
  • A New Approach to Treating Alzheimer's Disease
  • Part V. Mitochondria in Different Cell Types
  • Postischemic Oxidative Stress Promotes Mitochondrial Metabolic Failure in Neurons and Astrocytes
  • Imaging Brain Activation: Simple Pictures of Complex Biology
  • Structural Diversity of Mitochondria: Functional Implications
  • Part VI. Mitochondrial Function in Neurodegenerative Diseases
  • Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease
  • Complexity and Heterogeneity: What Drives the Ever-changing Brain in Huntington's Disease?
  • Multinuclear Magnetic Resonance Spectroscopy for in Vivo Assessment of Mitochondrial Dysfunction in Parkinson's Disease
  • Oxidant-induced Changes in Mitochondrial and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease
  • Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
  • Mitochondrial and Nuclear Cross Talk in Cell Death: Parthanatos
  • Role of the Ubiquitin Conjugation System in the Maintenance of Mitochondrial Homeostasis
  • Developmental Restructuring of the Creatine Kinase System Integrates Mitochondrial Engergetics with Stem Cell Cardiogenesis
  • The Mitochondrial Antioxidants MitoE[subscript 2] and MitoQ[subscript 10] Increase Mitochondrial Ca[superscript 2+] Load upon Cell Stimulation by Inhibiting Ca[superscript 2+] Efflux from the Organelle
  • Preventing NAD[superscript +] Depletion Protects Neurons against Excitotoxicity: Bioenergetic Effects of Mild Mitochondrial Uncoupling and Caloric Restriction
  • Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
  • Impairing the Mitochondrial Fission and Fusion Balance: A New Mechanism of Neurodegeneration
  • The Disulfide Relay of the Intermembrane Space of Mitochondria: An Oxygen-Sensing System?
  • Dysfunction of Mitochondria and Sarcoplasmic Reticulum in the Pathogenesis of Collagen VI Muscular Dystrophies
  • Part IX. Mitochondrial Effects on Genes and Gene Expression
  • Mitochondria and Hypoxia-induced Gene Expression Mediated by Hypoxia-inducible Factors
  • Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator
  • Part X. Gene Array and Proteomic Studies
  • Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction-induced Prevention of Alzheimer's Disease-type Amyloid Neuropathology and Spatial Memory Deterioration
  • Screening for the Metabolic Basis of Neurodegeneration: Developing a Focused Protemoic Approach
  • Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
  • Mitochondria and Huntington's Disease Pathogenesis: Insight from Genetic and Chemical Models
  • Small Molecule Activation of Adaptive Gene Expression: Tilorone or Its Analogs Are Novel Potent Activators of Hypoxia Inducible Factor-1 That Provide Prophylaxis against Stroke and Spinal Cord Injury
  • Mitochondrial Approaches for Neuroprotection
  • Index of Contributors