Target pattern recognition in innate immunity /
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| Imprint: | New York, N.Y. : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, c2009. |
|---|---|
| Description: | xx, 202 p. : ill. ; 26 cm. |
| Language: | English |
| Series: | Advances in experimental medicine and biology ; v. 653 |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/7788165 |
Table of Contents:
- 1. Macrophage Pattern Recognition Receptors in Immunity, Homeostasis and Self Tolerance
- Abstract
- Introduction
- The Scavenger Receptor Family
- Class A Scavenger Receptors
- SR-A (SR-AI/II)
- Marco
- SRCL-I/ CLP-I
- C-Type Lectin Receptors
- C-Type Lectins with a Single CRD
- C-Type Lectins with Multiple CRDs
- NK-Like C-Type Lectin-Like Receptors
- Self Tolerance in Innate Immunity
- Conclusion
- 2. Pattern Recognition by Toll-Like Receptors
- Abstract
- Introduction
- Toll-Like Receptors and Their Ligands
- Bacterial Recognition by TLRs
- Viral Recognition by TLRs
- Recognition of Fungi and Protozoan Parasites by TLRs
- Cellular Localization of TLRs
- Recognition of Endogenous Ligands by TLRs and Involvement in Autoimmunity
- TLR Signaling
- Interferon Production by TLRs
- TLR Structure
- TLR Expression in Cells of the Adaptive Immune System
- Conclusion
- 3. Nod-Like Receptors-Pivotal Guardians of the Immunological Integrity of Barrier Organs
- Abstract
- Introduction
- Nod-Like Receptors-Phylogenetically Ancient Molecular Platforms of the Innate Immune System
- Modular Domain Structure
- NLRs and the Recent Rise of Barrier Diseases
- Plasticity of NLR Function
- Conclusion
- 4. Toll-Like Receptors and Nod-Like Receptors: Domain Architecture and Cellular Signalling
- Abstract
- Introduction
- Toll-Like Receptors
- Myd88 Dependent TLR Signalling
- Myd88 Independent TLR Signalling
- Nod-Like Receptors
- Conclusion
- 5. Humoral Pattern Recognition Molecules: Mannan-Binding Lectin and Ficolins
- Abstract
- Introduction
- Biochemistry
- Biology
- Conclusion
- 6. Lung Surfactant Proteins A and D as Pattern Recognition Proteins
- Abstract
- Introduction
- Collection Structure Overview
- N-Terminal Region
- Collagen Region
- Neck Region
- Carbohydrate Recognition Domain (CRD)
- SP-A and SP-D Bind Lipid via Their CRDs
- Calcium Ions Are Required for CRD Function
- Factors Affecting Interaction with Polysaccharides
- Directing the Immune Response
- Specific Examples of SP-A and SP-D as PRRs
- Fungus and Yeast
- Viruses
- SP-A and SP-D in Protection against Allergens and Pulmonary Hypersensitivity
- Phenotype and Susceptibility of SP-A and SP-D Gene Deficient Mice
- Conclusion
- 7. Pattern Recognition by Pentraxins
- Abstract
- Pentraxins
- Short Pentraxins: CRP and SAP
- Long Pentraxin: PTX3
- Conclusion
- 8. Target Pattern Recognition by Complement Proteins of the Classical and Alternative Pathways
- Abstract
- The Complement System
- C1q and C1 Structure
- Biosynthesis of C1q
- Target Recognition by C1q
- Structural Basis of C1q Binding to Targets
- C1q Receptors
- C1q across the Animal Kingdom
- Properdin and the Alternative Pathway
- 9. Pattern Recognition in Phagocytic Clearance of Altered Self
- Abstract
- Roles and Mechanisms of Phagocytosis
- Recognition of Altered Self by Phagocytes
- Consequences of Phagocytic Clearance of Apoptotic Cells
- Fate of Necrotic Cells or Cells Dying by Other Modes
- Conclusion
- 10. Structural Basis of Pattern Recognition by Innate Immune Molecules
- Abstract
- Introduction
- Molecules Containing Leucine Rich Repeats (LRRs)
- Carbohydrate Recognition by C-Type Lectin and C-Type Lectin-Like Molecules
- Emerging Innate Immune Pattern Recognition Molecules
- Conclusion
- 11. Lessons From the Fly: Pattern Recognition in Drosophila Melanogaster
- Introduction
- The Immune Response in the Fly
- The Pattern Recognition Receptors
- Conclusion
- 12. Immune Recognition of Plasmodium-Infected Erythrocytes
- Malaria
- Clinical Immunity to P. falciparum Infection
- Involvement of Pattern Recognition Receptors in Plasmodium Infection
- Recognition of Plasmodium-iRBCs by Toll-Like Receptors
- Recognition of Plasmodium-iRBCs by Scavenger Receptors
- Conclusion
- 13. Innate Immune Recognition in Tuberculosis Infection
- Abstract
- Introduction
- Receptor-Mediated Phagocytosis of M. Tuberculosis
- Complement Receptors
- Mannose Receptors
- Scavenger Receptors
- Survival of M. tuberculosis inside the Phagosome
- Immune Recognition of M. tuberculosis
- Cytokines Induced in Response to M. tuberculosis Infection
- Conclusion
- Index
