Lipid A in cancer therapy /
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| Imprint: | New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, c2009. |
|---|---|
| Description: | xvi, 136 p. : ill. ; 26 cm. |
| Language: | English |
| Series: | Advances in experimental medicine and biology ; v. 667 Advances in experimental medicine and biology ; v. 667. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/7904227 |
Table of Contents:
- Foreword
- 1. Introduction: Historical Background
- 2. Structure and Synthesis of Lipid A
- Introduction
- General Architecture of Lipid A
- Structural Variations of Lipid A
- Chemical Synthesis of Lipid A
- Conclusion
- 3. Conformation and Supramolecular Structure of Lipid A
- Abstract
- Introduction
- Aggregate Structure and Molecular Conformation
- Intramolecular Conformation
- Phase States and Transitions between Them
- Molecular Modelling
- Physicochemical Data in Relation to Biological Activity
- Conformational Concept of Lipid A Action: How Does Endotoxin Interact with Immune Cells?
- 4. Interactions Between Lipid a and Serum Proteins
- Abstract
- Proteins Involved in Lipid A/LPS-Mediated Immune Cell Activation
- Detection of Lipid a by Immunoglobulins
- Proteins Involved in Lipid A/LPS Transport
- Lipoproteins
- Proteins Neutralizing the Immune-Cell Activating Properties of Lipid A/LPS
- Conclusion
- 5. The Lipid A Receptor
- Abstract
- Introduction
- Components of the Lipid A Receptor
- Conclusion
- 6. Lipid A Receptor TLR4-Mediated Signaling Pathways
- Abstract
- Introduction
- The MyD88-Dependent and MyD88-Independent Pathways
- TRIF: The TIR Domain-Containing Signal Transducer for the MyD88-Independent Pathway
- TIRAP and TRAM: Another Two TIR Domain-Containing Molecules
- Negative Regulation of LPS-Induced Signaling Pathways
- Two-Step Gene Induction Program in TLR4-Mediated Immune Responses
- Conclusion
- 7. Lipid A-Induced Responses In Vivo
- Abstract
- Fate of Lipid A in the Bloodstream
- General Immune Responses to Lipid A
- Systemic Toxicity
- Lipid A Tolerance
- Tumor Immune Responses
- Vascular Response
- Conclusion
- 8. Lipid A-Mediated Tolerance And Cancer Therapy
- Abstract
- Early, Late and Cross Tolerance
- The Isolation of Various Lipid A Structures and Synthesis of Analogs
- Relevance of Tolerance to the Use of LPS/Lipid A in Cancer
- Mechanisms of Early LPS/Lipid A-Mediated Tolerance
- Mechanisms of Tolerance of Other Lipid A Structures and LPS Antagonists
- Conclusion
- 9. Lipid A In Cancer Therapies: Preclinical Results
- Abstract
- Introduction
- LPS Treatments
- Lipids A Treatments
- DT-5461
- ONO-4007
- OM-174
- Conclusion
- 10. Monophosphoryl Lipid A (MPL) As An Adjuvant For Anti-Cancer Vaccines: Clinical Results
- Abstract
- Section 1: Vaccines Targeting Specific Cancer Types
- Section 2: Vaccines Targeting Specific TAAs Expressed on Multiple Tumor Types
- Conclusion
- 11. Antitumoral Effects Of Lipids A, Clinical Studies
- Abstract
- Introduction
- Immunological Background Underlying the Clinical Potential Interest
- Clinical Studies
- Conclusion
- 12. Conclusion
- Index
