Review by Choice Review
Collins, NIH director and a leader of the US effort in the International Human Genome Project, writes in plain English about the profound advancements of recent decades in scientists' understanding of how DNA works at the molecular level and the resulting implications for improvement of the accuracy of disease diagnoses and effectiveness of therapies. Numerous stories, some from the author's family, help explain statistical risks and developments in therapies for diseases including breast and other cancers, cystic fibrosis, chronic myeloid leukemia, and Marfan syndrome. Collins discusses concerns about genetic discrimination that could result from knowledge of an individual's genetic sequence. Chapters conclude with recommendations for "what you can do now to join the personalized medicine revolution." Appendixes provide a primer in genetics, history of the Human Genome Project, discussion of drug development, and tabulated comparison of results that Collins received from three direct-to-consumer genome sequencing companies that analyzed his DNA. A glossary is excerpted from the Talking Glossary of Genetic Terms (CH, May'10, 47-4777). Collins exhorts individuals to take responsibility for their own health and claims that readers of this book likely will know more than their health care providers about personalized medicine. Summing Up; Recommended. Undergraduate academic and public library collections; lower-level undergraduates and above, and general readers. F. G. Shrode Utah State University
Copyright American Library Association, used with permission.
Review by Booklist Review
Currently chief of the National Institutes of Health, Collins directs this work to those considering researching their double helix to assess their risk for hereditary diseases. Providing an idea of how risks are reckoned, ranging from certainty to probabilities, Collins gives a general explanation of both the Mendelian idea of dominant and recessive genes and the molecular biology of DNA. Collins' work is then organized by various diseases such as cancer, on which a vista of diagnostic opportunity has opened due to the decoding of the human genome (Collins was the leader of the government's decoding effort). With his prose reflecting a palpable excitement at the prospects of this new form of medicine, which he rates as nothing less than a revolution in human health, Collins combines uplifting cases of direly afflicted people who benefited from knowledge gained by genetic screening, with exhortation of the reader to learn about and take advantage of existing and developing techniques of genetic screening. Expect significant patron interest in Collins' combination of science and practical information.--Taylor, Gilbert Copyright 2009 Booklist
From Booklist, Copyright (c) American Library Association. Used with permission.
Review by Publisher's Weekly Review
A medical revolution is upon us and bestselling author Collins (The Language of God), director of the National Institutes of Health, does a fabulous job of explaining its dimensions. Our knowledge of the genetic basis for disease has increased exponentially in recent years, and we are now able to understand and treat diseases at the molecular level with personalized medicine-care based on an individual's genetic makeup. Collins presents cutting-edge science for lay readers who want to take control of their medical lives. In an enjoyable form, he discusses cancer, obesity, aging, racial differences, and a host of other concerns. Most fascinating is the way Collins discusses the medical advances currently in place and those soon to come that are directly attributable to the federal government's Human Genome Project, headed by Collins, and which mapped the entire human genome. Collins is also not shy about taking on large political issues. He points out problems with our current health-care system, discusses stem-cell research, and in a cogent commentary, recommends-with caveats-direct-to-consumer DNA testing. By using case studies throughout, he does a superb job of humanizing a complex scientific and medical subject. Illus. (Jan.) (c) Copyright PWxyz, LLC. All rights reserved
(c) Copyright PWxyz, LLC. All rights reserved
Review by Library Journal Review
This readable book by Collins (The Language of God), the current director of the National Institutes of Health and former director of the National Human Genome Research Institute, can help anyone understand more about how genetics and our DNA contribute to our health. Noting that many diseases are hereditary in origin, Collins reports on the latest breakthroughs in genetics research and discusses how these findings can personalize our medical care, including learning about disease risk, better treatments, and better drug choices and dosages based on our DNA. To illustrate his discussion, the author incorporates actual medical cases and offers some predictions for what we can expect from genetic research in the future, including ways to prevent aging. Each chapter concludes with a list of things to do, e.g., web sites to check and topics to discuss with your doctor. Appendixes cover the basics of genetics and drug development, as well as a comparison of direct-to-consumer DNA testing companies. VERDICT Highly recommended for lay readers interested in their health and health-care workers who need to learn about personalized medicine. [See Prepub Alert, LJ 9/15/09.]-Margaret Henderson, Virginia Commonwealth Univ., Richmond (c) Copyright 2010. Library Journals LLC, a wholly owned subsidiary of Media Source, Inc. No redistribution permitted.
(c) Copyright Library Journals LLC, a wholly owned subsidiary of Media Source, Inc. No redistribution permitted.
Review by Kirkus Book Review
The new director of the National Institutes of Health and former leader of the government's project to map the human genome is upbeat about personalized medicineusing genetics and family history to determine your risk for disease and designing appropriate treatments accordingly. Collins (The Language of God: A Scientist Presents the Evidence for Belief, 2006) anonymously investigated three leading commercial firms offering genetic analyses by sending them a cheek swab or saliva sample to be measured against gene variants associated with a range of diseases, as well as sensitivity to some commonly used drugs. Gratifyingly, the firms were consistent in their results, although the costs ranged from a few hundred to a few thousand dollars. Already Collins has adopted some lifestyle changes to improve his odds of avoiding conditions for which he is at risk. His point is that personalized medicine is here now, even though scientists have just scratched the surface of conditions for which genetic risk can be identified. Soon the science will accelerate and the costs will come down. Unfortunately, there are no cures for Huntington's or Alzheimer's disease, so some people may not want to know their risk. Others may want to know if they or an intended spouse are carriers of a recessive disease. Indeed, there are many moral/ethical issues that Collins raises as he reviews the science. He is a first-rate, entertaining expositor, taking the reader through Genetics 101 and providing case studies about genetic medicine in relation to common cancers, aging, the brain, infections and immunity. One striking case was that of an AIDS patient with leukemia who received a stem-cell transplant from a donor with a mutation preventing the AIDS virus from infecting immune cells. The transplant took and the patient was cured of his leukemia and AIDS. Collins does not demean the role of environment and accidents in his enthusiasm for personalized medicine, and he only lightly treads on issues of genes for sexuality, intelligence, etc., professing skepticism. Even if readers aren't ready to swab their cheeks today, they will learn a lot about the current state of DNA science and its potential. Copyright Kirkus Reviews, used with permission.
Copyright (c) Kirkus Reviews, used with permission.
Review by Choice Review
Review by Booklist Review
Review by Publisher's Weekly Review
Review by Library Journal Review
Review by Kirkus Book Review
