Computational toxicology : risk assessment for pharmaceutical and environmental chemicals /
Saved in:
| Imprint: | Hoboken, N.J. : Wiley-Interscience, c2007. |
|---|---|
| Description: | xxii, 814 p. : ill. (some col.) ; 25 cm. |
| Language: | English |
| Series: | Wiley series on technologies for the pharmaceutical industry Wiley series on technologies for the pharmaceutical industry. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/7995561 |
| Summary: | A comprehensive analysis of state-of-the-art molecular modelingapproaches and strategies applied to risk assessment forpharmaceutical and environmental chemicals<br> <br> This unique volume describes how the interaction of molecules withtoxicologically relevant targets can be predicted usingcomputer-based tools utilizing X-ray crystal structures orhomology, receptor, pharmacophore, and quantitative structureactivity relationship (QSAR) models of human proteins. It coversthe in vitro models used, newer technologies, and regulatoryaspects. The book offers a complete systems perspective to riskassessment prediction, discussing experimental and computationalapproaches in detail, with:<br> *<br> <br> An introduction to toxicology methods and an explanation ofcomputational methods<br> *<br> <br> In-depth reviews of QSAR methods applied to enzymes, transporters,nuclear receptors, and ion channels<br> *<br> <br> Sections on applying computers to toxicology assessment in thepharmaceutical industry and in the environmental arena<br> *<br> <br> Chapters written by leading international experts<br> *<br> <br> Figures that illustrate computational models and references forfurther information<br> <br> This is a key resource for toxicologists and scientists in thepharmaceutical industry and environmental sciences as well asresearchers involved in ADMET, drug discovery, and technology andsoftware development. |
|---|---|
| Physical Description: | xxii, 814 p. : ill. (some col.) ; 25 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9780470049624 0470049626 |
