Computational toxicology : risk assessment for pharmaceutical and environmental chemicals /
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| Imprint: | Hoboken, N.J. : Wiley-Interscience, c2007. |
|---|---|
| Description: | xxii, 814 p. : ill. (some col.) ; 25 cm. |
| Language: | English |
| Series: | Wiley series on technologies for the pharmaceutical industry Wiley series on technologies for the pharmaceutical industry. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/7995561 |
Table of Contents:
- Series Introduction
- Preface
- Acknowledgments
- Contributors
- Part I. Introduction to Toxicology Methods
- 1. An Introduction to Toxicology and Its Methodologies
- 2. In vitro Toxicology: Bringing the In silico and In vivo Worlds Closer
- 3. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling
- 4. Species Differences in Receptor-Mediated Gene Regulation
- 5. Toxicogenomics and Systems Toxicology
- Part II. Computational Methods
- 6. Toxicoinformatics: An Introduction
- 7. Computational Approaches for Assessment of Toxicity: A Historical Perspective and Current Status
- 8. Current QSAR Techniques for Toxicology
- Part III. Applying Computers to Toxicology Assessment: Pharmaceutical
- 9. The Prediction of Physicochemical Properties
- 10. Applications of QSAR to Enzymes Involved in Toxicology
- 11. QSAR Studies on Drug Transporters Involved in Toxicology
- 12. Computational Modeling of Receptor-Mediated Toxicity
- 13. Applications of QSAR Methods to Ion Channels
- 14. Predictive Mutagenicity Computer Models
- 15. Novel Applications of Kernel-Partial Least Squares to Modeling a Comprehensive Array of Properties for Drug Discovery
- 16. Homology Models Applied to Toxicology
- 17. Crystal Structures of Toxicology Targets
- 18. Expert Systems
- 19. Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D
- 20. Application of Interpretable Models to ADME/TOX Problems
- Part IV. Applying Computers to Toxicology Assessment: Environmental
- 21. The Toxicity and Risk of Chemical Mixtures
- 22. Environmental and Ecological Toxicology: Computational Risk Assessment
- 23. Application of QSARs in Aquatic Toxicology
- 24. Dermatotoxicology: Computational Risk Assessment
- Part V. New Technologies for Toxicology: Future and Regulatory Perspectives
- 25. Novel Cell Culture Systems: Nano and Microtechnology for Toxicology
- 26. Future of Computational Toxicology: Broad Application into Human Disease and Therapeutics
- 27. Computational Tools for Regulatory Needs
- Index
