Antisense drug technology : principles, strategies, and applications /
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| Edition: | 2nd ed. |
|---|---|
| Imprint: | Boca Raton : CRC Press, c2008. |
| Description: | xvii, 825 p., [12] p. of plates : ill. (some col.) ; 27 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8047512 |
Table of Contents:
- Preface
- Acknowledgments
- The Editor
- Contributors
- Part I. Introduction
- Chapter 1. Mechanisms of Antisense Drug Action, an Introduction
- Chapter 2. The RNase H Mechanism
- Chapter 3. Small RNA Silencing Pathways
- Chapter 4. Splice Switching Oligonucleotides as Potential Therapeutics
- Part II. The Basics of Oligonucleotide-Based Therapeutics
- Chapter 5. Basic Principles of Antisense Drug Discovery
- Chapter 6. The Medicinal Chemistry of Oligonucleotides
- Chapter 7. Basic Principles of the Pharmacokinetics of Antisense Oligonucleotide Drugs
- Chapter 8. Routes and Formulations for Delivery of Antisense Oligonucleotides
- Chapter 9. Liposomal Formulations for Nucleic Acid Delivery
- Part III A. Hybridization-Based Drugs: Basic Properties 2'-O-Methoxyethyl Oligonucleotides
- Chapter 10. Pharmacological Properties of 2'-O-Methoxyethyl-Modified Oligonucleotides
- Chapter 11. Pharmacokinetic/Pharmacodynamic Properties of Phosphorothioate 2'-O-(2-Methoxyethyl)-Modified Antisense Oligonucleotides in Animals and Man
- Chapter 12. Toxicologic Properties of 2'-O-Methoxyethyl Chimeric Antisense Inhibitors in Animals and Man
- Chapter 13. An Overview of the Clinical Safety Experience of First- and Second-Generation Antisense Oligonucleotides
- Chapter 14. Manufacturing and Analytical Processes for 2'-O-(2-Methoxyethyl)-Modified Oligonucleotides
- Part III B. Hybridization-Based Drugs: Basic Properties Duplex RNA Drugs
- Chapter 15. Utilizing Chemistry to Harness RNA Interference Pathways for Therapeutics: Chemically Modified siRNAs and Antagomirs
- Chapter 16. Discovery and Development of RNAi Therapeutics
- Part IV. Other Chemical Classes of Drugs
- Chapter 17. Optimization of Second-Generation Antisense Drugs: Going Beyond Generation 2.0
- Chapter 18. Modulating Gene Function with Peptide Nucleic Acids (PNA)
- Chapter 19. Locked Nucleic Acid
- Chapter 20. Morpholinos
- Part V. Therapeutic Applications
- Chapter 21. Potential Therapeutic Applications of Antisense Oligonucleotides in Ophthalmology
- Chapter 22. Cardiovascular Therapeutic Applications
- Chapter 23. Developing Antisense Drugs for Metabolic Diseases: A Novel Therapeutic Approach
- Chapter 24. Inflammatory Diseases
- Chapter 25. Antisense Oligonucleotides for the Treatment of Cancer
- Chpater 26. Targeting Neurological Disorders with Antisense Oligonucleotides
- Chapter 27. Mechanisms and Therapeutic Applications of Immune Modulatory Oligodeoxynucleotide and Oligoribonucleotide Ligands for Toll-Like Receptors
- Chapter 28. Aptamer Opportunities and Challenges
- Index
