Inflammatory diseases of the central nervous system /

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Bibliographic Details
Imprint:	Cambridge ; New York : Cambridge University Press, 2010.
Description:	viii, 271 p., [8] p. of plates : ill. (some col.) ; 26 cm.
Language:	English
Series:	Cambridge medicine Cambridge medicine (Series.
Subject:	Central nervous system -- Diseases. Inflammation. Central Nervous System -- immunology. Central Nervous System -- physiopathology. Central Nervous System Diseases -- immunology. Inflammation. Neuroimmunomodulation -- physiology. Central nervous system -- Diseases. Inflammation.
Format:	Print Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/8121005

Hidden Bibliographic Details
Other authors / contributors:	Kilpatrick, Trevor, 1959- Ransohoff, Richard M. Wesselingh, Steven.
ISBN:	9780521888745 (hardback) 0521888743 (hardback)
Notes:	Includes bibliographical references and index.
Summary:	"Interactions between the immune and nervous systems are involved in many disease processes. Modulation of inflammation can provide an important opportunity to enhance regeneration within the central nervous system. This authoritative book defines the key cellular players in mounting an inflammatory response and highlights critical factors in the target organ that influence the nature of that response and its capacity either to damage or protect the brain. Several key clinical areas are highlighted - particularly autoimmune diseases of the nervous system including multiple sclerosis, as well as microbiological and traumatic challenges; the book therefore provides both a summary of the basic science background as well as practical, clinical-friendly guidelines to management. The book will be of interest to a wide range of physicians, including neurologists, neurosurgeons, neurorehabilitationists, infectious disease physicians, and clinical neuroscientists, as well as neuroscientists and immunologists"--Provided by publisher.

Table of Contents:

Preface
Part I. Interactions Between the Immune and Nervous Systems
1. Effectors and determinants of the innate and adaptive immune responses
2. Microglia: protective and pathogenic mediators
3. The role of dendritic cells in neuroinflammation
4. Negotiating the brain barriers: access of immune cells and pathogens into the CNS
Part II. Autoimmunity
5. Immune effector heterogeneity in multiple sclerosis and related CNS inflammatory demyelinating disorders
6. Multiple sclerosis: neuroimmune crosstalk in acute and progressive stages of the disease
7. CD8+ T Cell-mediated autoimmune diseases in the CNS
8. Acute disseminated encephalomyelitis: determinants and manifestations
9. Primary angiitis of the CNS and its mimics
Part III. Microbiological and Traumatic Challenges to the CNS
10. Acute viral encephalitis: role of the immune system in viral clearance from the CNS and in the generation of pathology
11. Chronic HIV infection of the CNS: role of the immune system in virological control and the generation of pathology
12. Brain inflammation during bacterial meningitis
13. Parasitic infections of the brain: malaria and beyond
14. Role of the inflammatory process in traumatic brain damage
Part IV. Therapy
15. HIV-associated neurocognitive disorders: clinical features and therapeutic challenges
16. Role of immunomodulation in management of infections of the CNS
17. Neuroinflammation: an emerging therapeutic target in neurological disease
Index

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