Structural biology of DNA damage and repair /
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| Imprint: | Washington, DC : American Chemical Society, 2010. |
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| Description: | xi, 125 p., [4] leaves of plates (col.) : ill., charts ; 24 cm. |
| Language: | English |
| Series: | ACS symposium series ; 1041 ACS symposium series ; 1041. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8363488 |
| Summary: | The human genome is continuously exposed to many classes of genotoxins. Of these, three that will be discussed herein include 5,6-dihydroxy-5,6- dihydrothymine (thymine glycol; Tg), O6-methylguanine (O6MeG), and benzo[a]pyrene. In all cases, if the genome is not repaired, these and other genotoxic lesions precipitate serious biological consequences, including altered gene expression, mutation, and cell death. In addition to the genotoxic responses, it is increasingly being recognized that DNA lesions can alter the epigenetic profiles that are imprinted by naturally occurring DNA modifications.<br> <br> The impetus for this volume came from a recent symposium sponsored by the ACS Division of Chemical Toxicology, bringing together scientists interested in the synthesis and structures of site-specific DNA adducts and in mechanistic aspects of DNA repair. This volume presents work at the interface between the structural biology of DNA damage and DNA repair. |
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| Physical Description: | xi, 125 p., [4] leaves of plates (col.) : ill., charts ; 24 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9780841225749 0841225745 |
