An introduction to clinical pharmaceutics /
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| Author / Creator: | Florence, A. T. (Alexander Taylor) |
|---|---|
| Imprint: | London ; Chicago : Pharmaceutical Press, 2010. |
| Description: | xiii, 179 p. : ill. ; 24 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8380266 |
Table of Contents:
- Preface
- Introduction
- Book outline
- About the author
- 1. What is clinical pharmaceutics?
- Introduction
- Physical concepts
- The nature of the dosage form and outcomes
- Quality of effect
- Ingredients in dosage forms and their influence on outcomes
- Conclusion
- References
- 2. Excipients: Not always inert
- Introduction
- Usually but not always inert
- E-numbers
- Cross-reactivity
- Dyes used in lymph node identification
- Non-ionic surfactants
- Polyoxyethylene glycols (PEGs)
- Adjuvants as therapeutic substances
- Talc as therapeutic agent and excipient
- Active excipients in multiple therapies
- Conclusions
- References
- 3. Thinking chemically
- Introduction
- The chemistry of drugs and clinical pharmaceutics
- Chemical nomenclature
- Surface-active drugs
- Acids and bases
- Structural similarities between drugs
- Cross-reactivity
- Beta-lactam antibiotics and the formation of oligomers
- The bisphosphonates
- Hydrophobic and hydrophilic statins
- Photochemical reactions and photoinduced reactions
- Chelation and tetracyclines
- Sugammedex: a cyclodextrin derivative
- Conclusions
- References
- 4. Looking at formulations
- Introduction
- Protein drugs and formulations
- Monoclonal antibodies (MAbs)
- Amphotericin B formulations
- A doxorubicin formulation: Doxil
- A propofol formulation: Diprivan
- Long-acting depot injections
- Raft-producing oral formulations
- Etoposide (Vepesid, VP 16 and etoposide phosphate)
- Paclitaxel
- Eutectic mixtures of local anaesthetics
- Ciclosporin (cyclosporin)
- Lupron Depot; Prostap SR and Prostap 3
- Zoladex
- Fluoroquinolone eye drops
- Ionsys: lontophoretic transdermal device for fentanyl
- Parenterals
- Chloramphenicol
- Materials used in drug delivery
- Conclusions
- References
- 5. Adverse events and formulations and devices
- Introduction
- Dosage form type
- Reactions to impurities
- Abnormal bioavailability, high or low
- Testing for adverse effects
- Nanosystems
- Conclusions
- References
- 6. Paediatric, geriatric and special formulations
- Introduction
- Extemporaneous formulations
- Effect of formulation and presentation: a case from the literature
- Extemporaneous formulations and performance
- The elderly and their medication
- Enteral feeding
- Drug interactions with nutrient formulations
- Conclusions
- References
- 7. Generic medicines: Conventional drugs and biologicals
- Introduction
- Regulatory statements on generic products
- Generics: A question of quality
- Specific conditions and generics
- Reading and deconstructing the literature on bioequivalence
- Antiretroviral drugs
- Bioequivalence of ophthalmic products
- The case of sevoflurane
- Generic biologicals (biologics)
- Conclusions
- References
- 8. The future: Delivery systems for modem therapeutics
- Introduction
- Personalised medicine and medicines
- Drug delivery and personalised medicines
- Technologies
- Nanotechnoiogy
- Cell-based therapies
- Gene therapy
- Conclusions
- References
- Index
