Platelet-vessel wall interactions in hemostasis and thrombosis /

Platelet-vessel wall interactions in hemostasis and thrombosis /

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Bibliographic Details
Author / Creator:	Rumbaut, Rolando E.
Imprint:	San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2010.
Description:	1 electronic text (viii, 67 p. : ill.) : digital file.
Language:	English
Series:	Synthesis lectures on integrated systems physiology, from molecules to function, 1947-9468 ; # 4 Colloquium series on integrated systems physiology, from molecule to function, # 4.
Subject:	Thrombosis. Hemostasis. Blood platelets. Thrombosis. Hemostasis. Blood Platelets. Blood -- Coagulation. Blood platelets.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/8512928

Hidden Bibliographic Details
Other authors / contributors:	Thiagarajan, Perumal.
ISBN:	9781615040407 (electronic bk.) 9781615040391 (pbk.)
Notes:	Title from PDF t.p. (viewed on March 17, 2010). Series from website. Includes bibliographical references (p. 45-67). Abstract freely available; full-text restricted to subscribers or individual document purchasers. Mode of access: World Wide Web. System requirements: Adobe Acrobat reader.
Summary:	Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions.
Standard no.:	10.4199/C00007ED1V01Y201002ISP004

Table of Contents:

1. Introduction
2. General characteristics of platelets
Overview
Platelet granules
Alpha granules
Dense granules
Lysosomes
Platelet adhesion molecules
P-selectin
Glycoprotein Ib/IX/V (GPIb/IX/V)
Glycoprotein IIb/IIIa (GP IIb/IIIa)
Collagen receptors
G-protein-coupled receptors
Thrombin
Adenosine diphosphate (ADP) and adenosine triphosphate (ATP)
Prostanoids
3. Platelet adhesion to vascular walls
Adhesion to subendothelium following vascular injury
Von Willebrand factor (vWF)
Collagen
Other subendothelial components
Endogenous mechanisms preventing platelet adhesion to endothelium
Nitric oxide
Prostacyclin
Ecto-adenosine diphosphatase (ADPase)
Endothelial surface layer
Mechanisms of platelet adhesion to endothelium
Endothelial P-selectin-dependent mechanisms
Endothelial vWF-dependent mechanisms
Other mechanisms
4. Platelet aggregation
Mechanisms of platelet aggregation
Monitoring of platelet aggregation
Ex vivo monitoring: platelet aggregometry
In vivo monitoring of platelet aggregation
5. Platelet recruitment and blood coagulation
Role of platelets
Role of platelet-leukocyte interactions
6. Arterial, venous, and microvascular hemostasis/thrombosis
Venous thrombosis
Endothelial injury
Hypercoagulability
Stasis
Coexistence of Virchow's triad components: cancer and thrombosis
Arterial thrombosis
Microvascular thrombosis
7. Summary
Bibliography.