Inflammation and the microcirculation /
Saved in:
Author / Creator: | Granger, D. Neil. |
---|---|
Imprint: | San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2010. |
Description: | 1 electronic text (x, 87 p. : ill.) : digital file. |
Language: | English |
Series: | Integrated systems physiology, from molecule to function, 2154-5626 ; # 8 Colloquium series on integrated systems physiology, from molecule to function, # 8. |
Subject: | |
Format: | E-Resource Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8512933 |
Other authors / contributors: | Senchenkova, Elena. |
---|---|
ISBN: | 9781615041664 (electronic bk.) 9781615041657 (pbk.) |
Notes: | Title from PDF t.p. (viewed on July 14, 2010). Series from website. Includes bibliographical references (p. 65-87). Abstract freely available; full-text restricted to subscribers or individual document purchasers. Also available in print. System requirements: Adobe Acrobat reader. |
Summary: | The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. |
Standard no.: | 10.4199/C00013ED1V01Y201006ISP008 |
Similar Items
-
Microcirculation in inflammation : symposium held in conjunction with the 10th European Conference on Microcirculation, Cagliari, October 24, 1978 /
Published: (1979) -
Microcirculation in chronic venous insufficiency : 15th Bodensee Symposium on Microcirculation, Lindau, June 19-21, 1998 /
Published: (1999) -
Molecular basis for microcirculatory disorders /
by: Schmid-Schönbein, G. W.
Published: (2003) -
Coronary microvascular dysfunction /
by: Crea, Filippo
Published: (2013) -
The microcirculation in clinical medicine,
by: Wells, Roe
Published: (1973)