Systems biology in drug discovery and development /
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| Imprint: | Hoboken, N.J. : Wiley, c2012. |
|---|---|
| Description: | 1 online resource. |
| Language: | English |
| Series: | Wiley series on technologies for the pharmaceutical industry Wiley series on technologies for the pharmaceutical industry. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8551480 |
Table of Contents:
- Frontmatter
- Color Plates
- Introduction to Systems Biology in Approach. Introduction to Systems Biology in Drug Discovery and Development / Seth Michelson, Daniel L Young
- Methods for Biology: Model Construction and Analysis / Theresa Yuraszeck, Peter Chang, Kalyan Gayen, Eric Kwei, Henry Mirsky, Francis J Doyle
- Methods in Biology: Modeling Feedback Dynamics in Pathways / Peter Wellstead, Olaf Wolkenhauer
- Simulation of Population Variability in Pharmacokinetics / Jiansong Yang
- Applications to Drug Discovery. Applications of Systems Biology Approaches to Target Identification and Validation in Drug Discovery / Bart S Hendriks
- Lead Identification and Optimization / Seth Michelson
- Role of Core Biological Motifs in Dose₆Response Modeling: An Example with Switchlike Circuits / Sudin Bhattacharya, Qiang Zhang, Melvin E Andersen
- Mechanism-Based Pharmacokinetic₆Pharmacodynamic Modeling During Discovery and Early Development / Hans Peter Grimm, Ying Ou, Micaela Reddy, Pascale David-Pierson, Thierry Lav̌
- Applications to Drug Development. Developing Oncology Drugs Using Virtual Patients of Vascular Tumor Diseases / Zvia Agur, Naamah Bloch, Boris Gorelik, Marina Kleiman, Yuri Kogan, Yael Sagi, D Sidransky, Yael Ronen
- Systems Modeling Applied to Candidate Biomarker Identification / Ananth Kadambi, Daniel L Young, Kapil Gadkar
- Simulating Clinical Trials / Tom Parke
- Synergies with other Technologies. Pathway Analysis in Drug Discovery / Anton Yuryev
- Functional Mapping for Predicting Drug Response and Enabling Personalized Medicine / Yao Li, Wei Hou, Wei Zhao, Kwangmi Ahn, Rongling Wu
- Future Outlook for Systems Biology / Daniel L Young, Seth Michelson
- Index.
- Introduction to systems biology in drug discovery and development
- Methods for in silico biology : model construction and analysis
- Methods in in silico biology : modeling feedback dynamics in pathways
- Simulation of population variability in pharmacokinetics
- Applications of systems biology approaches to target identification and validation in drug discovery
- Lead identification and optimization
- The role of core biological motifs in dose-response modeling : an example with switch-like circuits
- Mechanism based pharmacokinetic-pharmacodynamic modeling during discovery and early development
- Developing oncology drugs using virtual patients of vascular tumor diseases
- Systems modeling applied to candidate biomarker identification
- Simulating clinical trials
- Pathway analysis in drug discovery
- Functional mapping for predicting drug response and enabling personalized medicine
- Future outlook of systems biology.