Caveolins and caveolae : roles in signaling and disease mechanisms /
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| Imprint: | New York, N.Y. : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, c2012. |
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| Description: | 1 online resource (xx, 184 p.) : ill. (some col.). |
| Language: | English |
| Series: | Advances in experimental medicine and biology ; v. 729 Advances in experimental medicine and biology ; v. 729. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8873316 |
| Summary: | Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm. |
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| Physical Description: | 1 online resource (xx, 184 p.) : ill. (some col.). |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9781461412229 1461412226 9781461412212 1461412218 |