Oncogenomics handbook /
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| Imprint: | Totowa, N.J. : Humana Press, c2005. |
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| Description: | 1 online resource (xvii, 750 p.) : ill. |
| Language: | English |
| Series: | Cancer drug discovery and development Cancer drug discovery and development. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8877351 |
Table of Contents:
- Part I. Genomics, Cancer Targets, Transcriptomics, and Gene Expression Analysis. Genomic Resources for Cancer Biologists / Xuefeng Bruce Ling, Gene Cutler, and Timothy Hoey ; Cancer Drug Target Identification by SAGE, LongSAGE, and Digital Karyotyping / Heiko Hermeking ; Identification of Novel Cancer Target Antigens Utilizing EST and Genome Sequence Databases / Tapan K. Bera, Kristi A. Egland, B.K. Lee, and Ira Pastan ; Tree-Based Cancer Classification and Diagnosis Using Gene Expression Data / Heping Zhang ; From FISH to Proteomics: A Molecular Brush to Define Antitumor Drug Action / Balanehru Subramanian, Alexander Nakeff, and Frederick Valeriote ; Gene Program Signatures for Papillomavirus E2-Mediated Senescence in Cervical Cancer Cells: Finding the Points of No Return / Sarah S. Williams, Bruce J. Aronow, and Susanne I. Wells
- Part II. Advances in Proteomic and Enzymatic Cancer-Profiling Technologies. Mass-Spectrometry-Based Proteomics for Cancer Biology / Chen Xu and John R. Yates III ; Chemical Proteomics in Drug Development / Douglas A. Jeffery, Amos Baruch, and Matthew Bogyo ; Proteomics-Based Anticancer Drug Discovery / K.K. Jain ; Cancer Metabolic Phenotype: Exploiting the Cancer Metabolome in Drug Discovery / John R. Griffiths and Marion Stubbs ; Focusing Target Discovery and Validation Through Proteogenomics and Molecular Imaging / Lucy A. Carver and Jan E. Schnitzer
- Part III. Cancer Target Validation: Cellular Approaches. RNA Interference: RNAid for Future Therapeutics? / Mustapha Diallo, Katja Schmitz, and Ute Schepers ; Image-Based Assays of Cellular Phenotype for Drug Target Discovery and Validation / Kris F. Sachsenmeier and Jonathan A. Terrett ; Targeting Inducible Chemotherapy Resistance Mechanisms in Colon Cancer / David Ljungman and James C. Cusack, Jr. ; Targeting Apoptosis Pathways for Cancer Therapy / Bharvin K.R. Patel.
- Part IV. Cancer Target Validation: Animal Approaches. Genetically Engineered Mouse Models of Human Cancer for Drug Discovery and Development / Rónán C. O'Hagan, Min Wu, William M. Rideout III, Yinghui Zhou, and Joerg Heyer ; Unraveling the Complexity of Oncogenesis Through In Vivo Optical Imaging / Pamela Reilly Contag ; Innovative Strategies for Improving Engineered Mouse Models of Human Cancer for Preclinical Development / Jeffrey J. Martino and Suzie Chen ; Use of Adenovirus-Mediated Gene Transfer to Facilitate Biological Annotation of Novel Genes / Jeff L. Ellsworth, Andrew Feldhaus, and Steven D. Hughes ; Cancer Biology and Transgenic Technology in the Mouse: Bridging the Functional Gap / Cindy E. McKinney and Cooduvalli S. Shashikant ; Homology-Based Genomic Mining of Growth Factors Implicated in Neoplasia and Nephritides: PDGF-D / Gary C. Starling, William J. LaRochelle, and Gulshan Ara
- PART V. Cancer Prognostics, Diagnostics, and Biomarkers. Cancer Pharmacogenomics: Predicting Drug Response in the Genomic Era / Brian Z. Ring and Huijun Z. Ring ; Diagnosis and Treatment of Malignancies Using Gene Expression Profiling / Jimmy C. Sung, Alice Y. Lee, and Timothy J. Yeatman ; Implications of Epigenetics for Early Cancer Diagnosis and Prevention / Mukesh Verma and Sudhir Srivastava ; Novel Molecular and Genetic Prognostic Biomarkers in Prostate Cancer / Arnab Chakravarti and Gary Guotang Zhai ; PSA in Prostate Cancer Diagnosis / Pradip Datta ; Tumor Targets and Biomarkers in Renal Cell Carcinoma / Ivar Bleumer and Peter F.A. Mulders
- PART VI. Emerging Approaches to Cancer Therapy: VI-A. Targeting the Vasculature. Tumor Vasculature as a Target for Cancer Therapy / Grzegorz Korpanty, Xianming Huang, and Rolf A. Brekken ; Targeting the VEGF/VEGFR Axis for Cancer Therapy / Frank A. Scappaticci ; Inhibiting Cancer Angiogenesis With Molecular Therapy / Qixin Leng and A. James Mixson
- VI-B. Supportive and Adjuvant Therapies. Development of Palifermin (rHuKGF) for Mucositis / Ping Wei and Catherine L. Farrell ; Immune Modulation: The B7 Family Cosignaling Molecules as Emerging Targets for Enhancing Cancer Therapy / Sheng Yao and Lieping Chen
- VI-C. Tumor-Targeted Therapies. Proteasome Inhibition and Its Clinical Application in Solid Tumors / David J. Park and Heinz-Josef Lenz ; Tumor Necrosis Factor Family of Ligands and Receptors in Cancer Therapy / Anas Younes and Andrea Cerutti ; Small-Molecule Receptor Tyrosine Kinase Inhibitors in Targeted Cancer Therapy / Carlos García-Echeverría ; The mTOR Pathway and Its Inhibitors / John B. Easton and Peter J. Houghton ; Cyclo-Oxygenase-2 Enzyme and Its Inhibition in Tumor Growth and Therapy / Zhongxing Liao, Uma Raju, Kathryn A. Mason, and Luka Milas ; Understanding Prostate-Specific Membrane Antigen and Its Implication in Prostate Cancer / Arundhati Ghosh and Warren D.W. Heston ; Development of a Radiolabeled Monoclonal Antibody to Prostate-Specific Membrane Antigen / Stanley J. Goldsmith, Shankar Vallabhajosula, Matthew I. Milowsky, David M. Nanus, Lale Kostakoglu, and Neil H. Bander ; Monoclonal Antibody Strategies for Targeting HER2 / Joan Albanell, Jeffrey S. Ross, Linda Pronk, and Pere Gascon ; From XenoMouse Technology to Panitumumab (ABX-EGF) / Xiaodong Yang, Lorin Roskos, C. Geoffrey Davis, and Gisela Schwab ; Development and Evaluation of Cancer Therapeutic Agents Targeting TRAIL Receptor 1 and 2 / Robin C. Humphreys ; Clinical Studies of Immunotherapy With Rituximab (Rituxan) and Radioimmunotherapy With Ibritumomab Tiuxetan (Zevalin) in B-Cell Lymphoid Malignancies / Arturo Molina
- PART VII. Informatics Strategies and Initiatives. Informatics Strategies and Initiatives Used in Cancer Research / Martin D. Leach.