Selective estrogen receptor modulators : a new brand of multitarget drugs /

Saved in:

Bibliographic Details
Imprint:	Berlin ; New York : Springer, c2006.
Description:	1 online resource (xvii, 357 p.) : ill.
Language:	English
Subject:	Selective estrogen receptor modulators. Menopause -- Hormone therapy. Estrogen -- Antagonists. Selective Estrogen Receptor Modulators -- pharmacology. Selective Estrogen Receptor Modulators -- therapeutic use. Estrogen Antagonists. Receptors, Estrogen. Estrogen -- Antagonists. Menopause -- Hormone therapy. Selective estrogen receptor modulators.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/8877502

Hidden Bibliographic Details
Other authors / contributors:	Sanchez, Antonio Cano. Calaf i Alsina, Joaquim. Dueñas-Díez, José-Luis.
ISBN:	3540242279 (alk. paper) 9783540242277 3540347429 (electronic bk.) 9783540347422 (electronic bk.) 6610716641 (electronic bk.) 9786610716647 (electronic bk.)
Notes:	Includes bibliographical references and index. Description based on print version record.
Summary:	The concept of selective estrogen receptor modulators (SERMs) has emerged recently in modern medicine. Two main features, the evidence of the wide expression of estrogen receptors in organs and systems and the growing information on the determinants of estrogen action, have allowed the envisioning of compounds with "a la carte" estrogenic profiles. The availability of substances performing as agonists wherever the estrogenic action is beneficial and as antagonists where it is not, is becoming less of a dream than of a closer reality. This book is an up-to-date review of the principal basic mechanisms and the clinical data integrating the actual current knowledge on SERMs.
Other form:	Print version: Selective estrogen receptor modulators. Berlin ; New York : Springer, c2006 3540242279
Standard no.:	9783540242277
Publisher's no.:	11372332

Description
Summary:	The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.
Physical Description:	1 online resource (xvii, 357 p.) : ill.
Bibliography:	Includes bibliographical references and index.
ISBN:	3540242279 9783540242277 3540347429 9783540347422 6610716641 9786610716647