Aromatase inhibitors /
Imprint: | Basel ; Boston : Birkhäuser, c2006. |
---|---|
Description: | 1 online resource (ix, 182 p.) : ill. |
Language: | English |
Series: | Milestones in drug therapy Milestones in drug therapy. |
Subject: | |
Format: | E-Resource Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8880387 |
Summary: | Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). |
---|---|
Physical Description: | 1 online resource (ix, 182 p.) : ill. |
Bibliography: | Includes bibliographical references and index. |
ISBN: | 9783764374181 3764374187 9783764371999 3764371994 |