Gene therapy for autoimmune and inflammatory diseases /

Gene therapy for autoimmune and inflammatory diseases /

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Bibliographic Details
Imprint:	Basel : Birkhäuser, c2010.
Description:	1 online resource (xi, 239 p.) : ill.
Language:	English
Series:	Milestones in drug therapy Milestones in drug therapy.
Subject:	Autoimmune diseases -- Gene therapy. Inflammation -- Gene therapy. Autoimmune Diseases -- therapy. Gene Therapy -- methods. Inflammation -- therapy.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/8895850

Hidden Bibliographic Details
Other authors / contributors:	Chernajovsky, Yuti. Robbins, Paul D.
ISBN:	9783034601658 (electronic bk.) 3034601654 (electronic bk.) 9783034601641 (Cloth) 3034601646 (Cloth) 9786613074577 6613074578
Notes:	Includes bibliographical references and index. Description based on print version record.
Summary:	This book addresses the latest advances in viral and non-viral vectors, novel targets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. The first section of the book deals with current research approaches for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery and vector development including plasmids, regulated promoters, adenovirus gutted vectors and adeno-associated vectors. All chapters are summarised by leaders in these fields. A must read for post graduate students, clinical and non-clinical researchers in the disciplines of immunology, molecular medicine, pharmacology, gene and cell-mediated therapy.
Other form:	Print version: Gene therapy for autoimmune and inflammatory diseases. Basel : Birkhäuser, c2010 9783034601641
Standard no.:	9786613074577

Description
Summary:	In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.
Physical Description:	1 online resource (xi, 239 p.) : ill.
Bibliography:	Includes bibliographical references and index.
ISBN:	9783034601658 3034601654 9783034601641 3034601646 9786613074577 6613074578