The malaria genome projects : promise, progress, and prospects /
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| Author / Creator: | Sherman, Irwin W. |
|---|---|
| Imprint: | London : Imperial College Press, c2012. |
| Description: | xv, 372 p. ; 24 cm. |
| Language: | English |
| Subject: | |
| Format: | E-Resource Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8923688 |
Table of Contents:
- Preface
- Chapter 1. Introduction
- Plasmodium discovered
- Plasmodium transmitted
- Plasmodium in hiding
- Chapter 2. Respice: Before the Genome Project
- Chapter 3. The Nature of Plasmodium falciparum and its Genome
- A home for the genome
- Location, location, location
- The malaria genome capers
- Chapter 4. Chipping Away at the Genome
- Turning "on," turning "off"
- Evasion
- Chapter 5. The Importance of Import
- Chapter 6. Remodeling the Genome's Home
- Chapter 7. Getting on the Inside
- Chapter 8. The Great Escape
- Chapter 9. The Neglected Malaria, Plasmodium vivax
- Resistance
- Secrets hidden in the genome
- Chapter 10. The Anopheles Genome and Transmission Control
- Making mosquitoes immune
- Making mosquitoes insecticide resistant
- Replacement and/or reduction
- Chapter 11. The Monkey's Tale
- Chapter 12. A Not so Sweet Solution
- Isoenzymes, the Achilles' heels of Plasmodium
- Tackling the Krebs "cycle"
- Chapter 13. To Search and Find
- Rapid diagnostic tests
- Nucleic acid-based tests
- Loop-mediated isothermal amplification
- Chapter 14. The Elusive Vaccines
- Antigens before the genome
- Two blood-stage vaccine candidates
- The road to merozoite surface protein
- The road to apical membrane antigen 1
- A failed promise, SPf66
- Transmission-blocking vaccines
- The sporozoite vaccine revisited
- Development of the pre-blood-stage vaccine, RTS, S
- Back to the future
- Learning from the liver
- Vaccine approaches before sequencing the genome
- Vaccine approaches after sequencing the genome
- Chapter 15. New Medicines, Old Problems
- The old problem of resistance
- Chloroquine
- Resistance to anti-folate drugs
- Mefloquine and multidrug resistance
- The fall of mefloquine
- Atovaquone
- Artemisia to artemisinins
- Chapter 16. Prospice: Looking to the Future
- References
- Index
