Endocrine disruptors and the developing brain /
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| Author / Creator: | Gore, Andrea C., 1964- |
|---|---|
| Imprint: | San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2012. |
| Description: | 1 online resource. |
| Language: | English |
| Series: | Colloquium series on the developing brain, 2159-5208 ; # 7 Colloquium digital library of life sciences. Colloquium series on the developing brain ; # 7. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8954457 |
Table of Contents:
- 1. What are environmental endocrine-disrupting chemicals (EDCs)?
- 1.1 Introduction to EDCS
- 1.2 Endocrine systems communicate with the environment
- 1.3 Hormonal properties and mechanisms of EDCS
- 1.3.1 Nuclear hormone receptors
- 1.3.2 Membrane hormone receptors
- 1.3.3 Steroidogenic enzymes
- 1.4 Representative EDCs and their actions
- 1.4.1 Industrial organohalogens (PCBs, PBDEs)
- 1.4.2 Pesticides (DDT, methoxychlor)
- 1.4.3 Phytoestrogens
- 1.5 Summary and conclusions
- 2. EDC exposures
- 2.1 EDCs and wildlife
- 2.1.1 Reproductive toxicity of EDCs in wildlife
- 2.2 EDCs and humans
- 2.2.1 Diethylstilbestrol (DES)
- 2.2.2 PCBS
- 2.2.3 Dioxins
- 2.2.4 Low-dose human exposures: what is the evidence?
- 2.3 Summary and conclusions
- 3. EDCs and development
- 3.1 Vulnerability of the developing fetus
- 3.2 Fetal (developmental) basis of adult disease
- 3.3 Critical developmental periods
- 3.4 Key toxicological principles relevant to developmental exposures
- 3.4.1 LOAEL/NOAEL
- 3.4.2 Dose-response principles and why they do not apply to EDCs
- 3.4.3 Low-dose effects of EDCs, lack of a threshold
- 3.5 Summary and conclusions
- 4. EDCs and the developing brain
- 4.1 Hormones and brain sexual differentiation
- 4.1.1 Hormones and neuronal survival and death
- 4.2 EDCs and the perturbation of brain sexual differentiation
- 4.2.1 Hypothalamic morphology
- 4.2.2 Hypothalamic developmental apoptosis
- 4.2.3 Neuronal phenotype
- 4.3 EDCs and reproductive behaviors
- 4.4 EDCs and non-reproductive behaviors
- 4.4.1 Hormones and synaptic plasticity
- 4.4.2 EDCs and neural plasticity
- 4.4.3 EDC effects on the brain's dopamine neurons
- 4.5 Summary and conclusions
- 5. EDCs and neuroendocrine systems
- 5.1 Neuroendocrine systems of the hypothalamus
- 5.2 Reproductive neuroendocrine systems and perturbations by EDCs
- 5.2.1 Background on GnRH neurons
- 5.2.2 Sexual differentiation of the HPG axis
- 5.2.3 Steroid hormone feedback and regulation of HPG function
- 5.2.4 Disruption of GnRH neurons by EDCs
- 5.2.4.1 In vitro evidence
- 5.2.4.2 In vivo evidence
- 5.2.4.3 Developmental EDC exposures and GnRH neurons
- 5.2.5 EDCs, puberty, and the brain
- 5.2.5.1 Disruption of puberty by environmental EDCs
- 5.2.5.2 Kisspeptin neurons are potential targets for developmental EDCs
- 5.3 Summary and conclusions
- 6. Epigenetic effects of EDCS
- 6.1 Molecular epigenetic mechanisms: an introduction
- 6.2 Hormones and epigenetic change
- 6.2.1 DNA methylation
- 6.2.2 Histone modifications
- 6.2.3 MicroRNAS
- 6.3 Transgenerational epigenetic effects of EDCs
- 6.3.1 Vinclozolin
- 6.3.2 Bisphenol A
- 6.3.3 Diethylstilbesterol (DES).
- 6.3.4 Polychlorinated biphenyls (PCBs).
- 6.3.5 Methoxychlor
- 6.4 The importance of context in environmental epigenetics
- 6.5 Summary and conclusions
- 7. EDCs, the brain, and the future
- 7.1 Can EDC effects be mitigated?
- 7.2 What can we do to avoid EDC exposures?
- 7.3 General conclusions
- Acknowledgments
- References
- Author biographies.
