The clinical neurobiology of the hippocampus : an integrative view /
Saved in:
| Imprint: | Oxford : Oxford University Press, c2012. |
|---|---|
| Description: | xvi, 310 p. : ill. ; 28 cm |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/9141654 |
Table of Contents:
- List of Contributors
- List of Abbreviations
- Epigraphs
- 1. Introduction: The Hippocampus in the Clinical Neurosciences
- History of hippocampal research
- Anatomical explorations
- Involvement of the hippocampus in neurological and psychiatric diseases
- Basic principles of the pathophysiology of the hippocampus
- Functions attributed to the hippocampus
- Structured the book
- Outlook
- 2. Functional Anatomy, Development, and Pathology of the Hippocampus
- Introduction
- Overall organization
- Postnatal development
- Neurodevelopmental disorders
- Conclusion
- 3. Amnesia and the Hippocampal Memory System
- Introduction
- Case H.M.
- Spared learning in H.M. and other patients with hippocampal damage
- What are the fundamental features of declarative and procedural memory?
- Temporally graded retrograde amnesia and memory consolidation
- Recent challenges about the defining features of declarative memory and their role in amnesia
- 4. Selective Neuronal Vulnerability in the Hippocampus: Relationship to Neurological Diseases and Mechanisms for Differential Sensitivity of Neurons to Stress
- Importance of the hippocampus in learning, memory, and neurological diseases
- The concept of selective neuronal vulnerability in the central nervous system
- Focus on selective neuronal vulnerability in the hippocampus
- Mechanisms of selective neuronal vulnerability
- Concluding ideas
- 5. Stress and the Hippocampus
- Introduction
- Pulsatility of basal HPA axis activity
- Stress-induced HPA axis activity
- MR- and GR-mediated behavioural effects
- Neuroendocrine regulation
- Morphology
- Network function
- Molecular effects
- MR and GR polymorphisms
- Early life experience
- Implication for diseases of the hippocampus
- 6. Adult Hippocampal Neurogenesis: Functional Implications of a 'New' Type of Plasticity
- Introduction: adult neurogenesis in the hippocampus
- Theories of hippocampal function
- Experimental evidence for a functional role of adult neurogenesis
- Conclusion
- 7. Imaging the Hippocampus
- Introduction
- Hippocampal neuroanatomy for neuroimaging
- Brief history of hippocampal neuroimaging
- Imaging and quantifying hippocampal and MTL cortical anatomy
- Imaging task-related hippocampal and MTL cortical function
- Imaging hippocampal perfusion and metabolism
- Imaging hippocampal connectivity
- Molecular imaging of the hippocampus
- Imaging hippocampal plasticity
- Ex vivo hippocampal imaging
- Technical advances and future directions
- 8. Sleep, Memory, and the Hippocampus
- Introduction
- Basic facts about sleep
- Behavioural evidence for a favourable effect of sleep on declarative memories
- The synaptic downscaling hypothesis
- The hypothesis of a hippocampo-neocortical dialogue during sleep
- Hippocampal activity during immediate post-training wakefulness
- 9. The Ageing Hippocampus
- Introduction
- Cross-species cognitive ageing
- Spatial memory
- Neuroanatomical changes in the hippocampus
- Biophysical properties of aged neurons
- Electropjiysiological measures of connectivity
- Neural plasticity
- Age-related changes in gene expression
- Dynamic alterations of Arc transcription-treatment approaches
- Dynamics of aged neural ensembles
- Summary
- 10. Neurodevelopmental Disorders
- Neurodevelopmental outcome in children born preterm and the hippocampus
- Febrile seizures and hippocampal sclerosis
- Embryo fetal alcohol syndrome
- Effects of cocaine on the developing hippocampus
- Autism spectrum disorder
- Angelman syndrome
- Down syndrome
- Fragile X syndrome
- Attention-deficit hyperactivity disorder
- Gilles de la Tourette syndrome
- Conclusions
- 11. The Hippocampus in Neurological Disease
- The vulnerability of the hippocampus in neurological disease
- MRI correlates of hippocampal damage
- Hippocampal ischaemia
- Anoxic encephalopathy
- Limbic encephalitis
- Epilepsy, status epilepticus, and postictal changes
- Traumatic brain injury
- Hypoglycaemic encephalopathy
- Transient global amnesia
- Multiple sclerosis
- 12. Alzheimer's Disease
- Introduction
- Alzheimer's disease
- Structural MRI
- Functional MRI
- Hippocampal structure and function in AD and MCI
- Concluding remarks
- 13. Temporal Lobe Epilepsy and the Hippocampus
- Introduction
- Mesial temporal sclerosis and epileptogenicity
- Clinical picture
- Electroencephalographic findings
- Neuroimaging in temporal lobe epilepsy
- Nuclear neuroimaging with positron emission tomography (PET) and single-photon emission computed tomography (SPECT)
- Treatment
- 14. The Hippocampus and Post-Traumatic Disorders
- Trauma spectrum psychiatric disorders
- Effects of stress on the hippocampus
- Hippocampal function in PTSD
- Glucocorticoids and the hippocampus
- Hippocampal and other glucocorticoid receptor expression as risk factors for PTSD
- Functional neuroimaging studies of the hippocampus in PTSD
- Hippocampus and pharmacotherapy for PTSD
- Summary and conclusions
- 15. The Hippocampus in Major Depression
- Introduction
- Regional morphological variation in the hippocampus in MDD
- Can hippocampal dysregulation be linked to MDD?
- Clinical and demographic variables influencing hippocampal volumes in MDD
- Biological mechanisms that may contribute to small hippocampal volume in MDD
- The clinical relevance of small hippocampal volumes in MDD
- Evidence that treatment for MDD may have an impact on hippocampal volumes
- Summary
- 16. Schizophrenia
- Epidemiology and aetiology of schizophrenia
- Symptoms of schizophrenia with focus on cognitive deficits
- Hippocampus and cognition in schizophrenia
- The hippocampus and schizophrenia: findings from MRI studies
- The hippocampus and schizophrenia: findings from structural postmortem studies
- From behaviour to the molecular basis of hippocampal alterations in schizophrenia
- Functional role of schizophrenia risk genes in the hippocampus
- Influence of antipsychotics on the hippocampus
- Author Index
- Subject Index
