The new paradigm of immunity to tuberculosis /

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Bibliographic Details
Imprint:	New York, NY : Springer, c2013.
Description:	1 online resource.
Language:	English
Series:	Advances in experimental medicine and biology, 0065-2598 ; v.783 Advances in experimental medicine and biology ; v.783.
Subject:	Tuberculosis -- Immunological aspects. Tuberculosis -- Vaccination. Tuberculosis -- Immunological aspects. Tuberculosis -- Vaccination. Tuberculosis -- immunology. Vaccination. Electronic books
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/9850304

Hidden Bibliographic Details
Other authors / contributors:	Divangahi, Maziar.
ISBN:	9781461461111 (electronic bk.) 1461461111 (electronic bk.) 9781461461104 1461461103 9781461461104
Notes:	Includes index. Online full text is restricted to subscribers.
Summary:	This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former's role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed.The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection.Finally, it is a synthesis of the authors' recent studies and the studies of others to offer a new understanding of immunity to tuberculosis.

Table of Contents:

Epidemiology of Tuberculosis Immunology / G. J. Fox, D. Menzies
Host-Pathogen Specificity in Tuberculosis / Tania Di Pietrantonio, Erwin Schurr
Genetic Determinants of Susceptibility to Mycobacterial Infections: IRF8, A New Kid on the Block / S. Salem, P. Gros
Evolution of Mycobacterium tuberculosis / Marcel A. Behr
Mycobacterium tuberculosis Genes Involved in Regulation of Host Cell Death / Volker Briken
Dying to Live: How the Death Modality of the Infected Macrophage Affects Immunity to Tuberculosis / Maziar Divangahi, Samuel M. Behar
Cytokines in the Balance of Protection and Pathology During Mycobacterial Infections / Egídio Torrado, Andrea M. Cooper
Antigen-Specific CD8+ T Cells and Protective Immunity to Tuberculosis / Samuel M. Behar
Foxp3+ Regulatory T Cells in Tuberculosis / Ryan P. Larson, Shahin Shafiani
CD1a, CD1b, and CD1c in Immunity Against Mycobacteria / Ildiko Van Rhijn, Dalam Ly, D. Branch Moody
CD1d and Natural Killer T Cells in Immunity to Mycobacterium tuberculosis / Pooja Arora, Erin L. Foster
The Role of B Cells and Humoral Immunity in Mycobacterium tuberculosis Infection / Lee Kozakiewicz, Jiayao Phuah, JoAnne Flynn
Looking Within the Zebrafish to Understand the Tuberculous Granuloma / Lalita Ramakrishnan
Immunization Strategies Against Pulmonary Tuberculosis: Considerations of T Cell Geography / Carly N. Horvath, Zhou Xing.

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