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130906s2013 nyu o 001 0 eng d |
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|a 9781461478768 (electronic bk.)
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|a 10.1007/978-1-4614-7876-8
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|a (OCoLC)857714017
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|a RC271.C5
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|a QZ 267
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0 |
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|a Cancer targeted drug delivery :
|b an elusive dream /
|c You Han Bae, Randall J. Mrsny, Kinam Park, editors.
|
| 264 |
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1 |
|a New York :
|b Springer,
|c 2013.
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| 300 |
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|a 1 online resource.
|
| 336 |
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|a text
|b txt
|2 rdacontent
|0 http://id.loc.gov/vocabulary/contentTypes/txt
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|a computer
|b c
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|g Part I:
|t History of Cancer Targeting Efforts.
|t A Time Travel Journey Through Cancer Therapies /
|r Ana S. Cravo, Randall J. Mrsny --
|t Nanotechnology for Cancer Treatment: Possibilities and Limitations /
|r Joseph W. Nichols, You Han Bae --
|g Part II:
|t Targeting Issues.
|t Vascular Targeting Approaches to Treat Cancer /
|r Joseph W. Wragg, Roy Bicknell --
|t Tumor Immunotherapy by Utilizing a Double-Edged Sword, Chemokines /
|r Naofumi Mukaida, So-ichiro Sasaki, Tomohisa Baba --
|g Part III:
|t General Tumor Physiology and Microenvironment Issues.
|t Cancer Biology: Some Causes for a Variety of Different Diseases /
|r Abood Okal, Shams Reaz, Carol S. Lim --
|t Cancer Stromal Targeting (CAST) Therapy and Tailored Antibody Drug Conjugate Therapy Depending on the Nature of Tumor Stroma /
|r Yasuhiro Matsumura., Masahiro Yasunaga, Shino Manabe --
|t Cancer Cell Respiration: Hypoxia and pH in Solid Tumors /
|r Dong Yun Lee, Taiyoun Rhim, Minhyung Lee --
|t Tumor Vasculature, EPR Effect, and Anticancer Nanomedicine: Connecting the Dots /
|r Sebastien Taurin ... et al. --
|t Pressure Gradients in Solid Tumors /
|r Shawn Stapleton, Michael F. Milosevic --
|t The ADAMs: New Therapeutic Targets for Cancer? /
|r M. J. Duffy ... et al. --
|t Role of the Extracellular Matrix: Enzyme Activities and Metastasis /
|r Il-Kyu Choi, Chae-Ok Yun --
|t The Role of Non-cancerous Cells in Cancer: Pancreatic Ductal Adenocarcinoma as a Model to Understand the Impact of Tumor Microenvironment on Epithelial Carcinogenesis /
|r Mert Erkan, Tania Brocks, Helmut Friess --
|g Part IV:
|t The Dynamic Problem of Tumor Heterogeneity.
|t Heterogeneity of Cancers and Its Implication for Targeted Drug Delivery /
|r Tracy A. Denison, You Han Bae. --
|t A Study of Cancer Heterogeneity: From Genetic Instability to Epigenetic Diversity in Colorectal Cancer /
|r Maria Giovanna Francipane., Eric Lagasse --
|t Nanotherapeutics in Multidrug Resistance /
|r Min Han, Jian-Qing Gao. --
|t Stem Cells and Cancer /
|r Dejuan Kong ... et al. --
|t Mechanisms of Metastasis /
|r Ngoc-Han Ha, Farhoud Faraji, Kent W. Hunter --
|g Part V:
|t Reaching Cancer Cells.
|t Cancer-Specific Ligand-Receptor Interactions /
|r Ewelina Kluza ... et al. --
|t Targeting Drugs to Cancer: A Tough Journey to the Tumor Cell /
|r Shiran Ferber, Galia Tiram, Ronit Satchi-Fainaro --
|t Long Circulation and Tumor Accumulation /
|r Sandra N. Ekdawi ... et al. --
|t Convective and Diffusive Transport in Drug Delivery /
|r Abraham R. Tzafriri, Elazer R. Edelman --
|t Intravital Real-Time Confocal Laser Scanning Microscopy for the In Situ Evaluation of Nanocarriers /
|r Yu Matsumoto ... et al. --
|t The EPR Effect in Cancer Therapy /
|r Ji Young Yhee ... et al. --
|g Part VI:
|t Preclinical Modeling.
|t In Vitro Three-Dimensional Cancer Culture Models /
|r Waseem Asghar ... et al. --
|t Complex Transport Around Tumor: Need for Realistic In Vitro Tumor Transport Model /
|r Bumsoo Han --
|g Part VII:
|t Prospective and Future Direction.
|t The Missing Components Today and the New Treatments Tomorrow /
|r Kinam Park, You Han Bae, Randall J. Mrsny.
|
| 500 |
|
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|a Includes index.
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| 520 |
|
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|a This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications. The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications. The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications. Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.
|
| 588 |
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|a Description based on print version record.
|
| 650 |
|
2 |
|a Drug Delivery Systems.
|
| 650 |
|
2 |
|a Neoplasms
|x drug therapy.
|
| 650 |
|
0 |
|a Cancer
|x Chemotherapy.
|0 http://id.loc.gov/authorities/subjects/sh85019497
|
| 650 |
|
0 |
|a Antineoplastic agents.
|0 http://id.loc.gov/authorities/subjects/sh85005714
|
| 650 |
|
0 |
|a Drug delivery systems.
|0 http://id.loc.gov/authorities/subjects/sh88007108
|
| 655 |
|
4 |
|a Electronic books.
|
| 650 |
|
7 |
|a Antineoplastic agents.
|2 fast
|0 http://id.worldcat.org/fast/fst00810595
|
| 650 |
|
7 |
|a Cancer
|x Chemotherapy.
|2 fast
|0 http://id.worldcat.org/fast/fst00845327
|
| 650 |
|
7 |
|a Drug delivery systems.
|2 fast
|0 http://id.worldcat.org/fast/fst00898667
|
| 700 |
1 |
|
|a Bae, You Han,
|e editor of compilation.
|0 http://id.loc.gov/authorities/names/n2014181180
|1 http://viaf.org/viaf/219922343
|
| 700 |
1 |
|
|a Mrsny, Randall J.,
|d 1955-,
|e editor of compilation.
|0 http://id.loc.gov/authorities/names/n99254134
|1 http://viaf.org/viaf/6728656
|
| 700 |
1 |
|
|a Park, Kinam,
|e editor of compilation.
|0 http://id.loc.gov/authorities/names/n93072288
|1 http://viaf.org/viaf/5033472
|
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|t Cancer targeted drug delivery
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