G Protein-coupled receptors-- Modeling and simulation /

Saved in:

Bibliographic Details
Imprint:	Dordrecht : Springer, ©2014.
Description:	1 online resource (228 pages).
Language:	English
Series:	Advances in Experimental Medicine and Biology, 0065-2598 796 Advances in experimental medicine and biology ; v. 796.
Subject:	G proteins -- Receptors. G proteins -- Receptors. Receptors, G-Protein-Coupled.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11081653

Hidden Bibliographic Details
Other authors / contributors:	Filizola, Marta.
ISBN:	9789400774230 9400774230 9789400774223
Notes:	Includes index. Print version record.
Summary:	G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors.
Other form:	Print version: 9789400774223

Table of Contents:

Part I: Progress in Structural Modeling of GPCRs
The GPCR Crystallography Boom: Providing an Invaluable Source of Structural Information and Expanding the Scope of Homology Modeling / Stefano Costanzi and Keyun Wang
Modeling of G Protein-Coupled Receptors Using Crystal Structures: From Monomers to Signaling Complexes / Angel Gonzalez, Arnau Cordomí, Minos Matsoukas, Julian Zachmann and Leonardo Pardo
Part II: GPCRs in Motion: Insights from Simulations
Structure and Dynamics of G-Protein Coupled Receptors / Nagarajan Vaidehi, Supriyo Bhattacharya and Adrien B. Larsen
How the Dynamic Properties and Functional Mechanisms of GPCRs Are Modulated by Their Coupling to the Membrane Environment / Sayan Mondal, George Khelashvili, Niklaus Johner and Harel Weinstein
Coarse-Grained Molecular Dynamics Provides Insight into the Interactions of Lipids and Cholesterol with Rhodopsin / Joshua N. Horn, Ta-Chun Kao and Alan Grossfield
Beyond Standard Molecular Dynamics: Investigating the Molecular Mechanisms of G Protein-Coupled Receptors with Enhanced Molecular Dynamics Methods / Jennifer M. Johnston and Marta Filizola
Part III: GPCR-Focused Rational Design and Mathematical Modeling
From Three-Dimensional GPCR Structure to Rational Ligand Discovery / Albert J. Kooistra, Rob Leurs, Iwan J.P. de Esch and Chris de Graaf
Mathematical Modeling of G Protein-Coupled Receptor Function: What Can We Learn from Empirical and Mechanistic Models? / David Roche, Debora Gil and Jesús Giraldo
Part IV: Bioinformatics Tools and Resources for GPCRs
GPCR & Company: Databases and Servers for GPCRs and Interacting Partners / Noga Kowalsman and Masha Y. Niv
Bioinformatics Tools for Predicting GPCR Gene Functions / Makiko Suwa.

G Protein-coupled receptors-- Modeling and simulation /

Similar Items